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List of works by Cinzia Tesauro

A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism.

scientific article published on 7 March 2013

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study

scientific article

Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin

scientific article

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I

scientific article (publication date: 2014)

Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement

scientific article

Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I.

scientific article published on 15 January 2010

Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant.

scientific article published on 18 September 2009

Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX

scientific article published on 30 April 2022

Interaction between natural compounds and human topoisomerase I.

scientific article

Isolation of functional mitochondria by inertial microfluidics – a new method to sort intracellular organelles from a small scale biological sample

scholarly article in RSC Advances, vol. 7 no. 38, 2017

Microfluidics-Enabled Enzyme Activity Measurement in Single Cells

scientific article published in January 2015

Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico

scientific article published on 03 September 2013

Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation

scientific article published on 22 April 2015

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers

scientific article

On-slide detection of enzymatic activities in selected single cells.

scientific article published on 5 September 2017

Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene.

scientific article published on 7 October 2015

Real-time analysis of cleavage and religation activity of human topoisomerase 1 based on ternary fluorescence resonance energy transfer DNA substrate.

scientific article published on 16 February 2018

Refined Method for Droplet Microfluidics-Enabled Detection of Plasmodium falciparum Encoded Topoisomerase I in Blood from Malaria Patients

scientific article published on 5 October 2015

Replacement of the human topoisomerase linker domain with the plasmodial counterpart renders the enzyme camptothecin resistant

scientific article (publication date: 2013)

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin

scientific article published on 19 January 2012

Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads

scientific article

Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification

scientific article

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.

scientific article published on 14 March 2016

The human DNA topoisomerase I mutant Gly717Asp: Higher religation rate is not always associated with camptothecin resistance

scientific article published on 14 January 2019

The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation.

scientific article

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