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List of works by Peter Šebo

A novel "clip-and-link" activity of repeat in toxin (RTX) proteins from gram-negative pathogens. Covalent protein cross-linking by an Asp-Lys isopeptide bond upon calcium-dependent processing at an Asp-Pro bond

scientific article published on 24 March 2004

Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice

scientific article published on 19 November 2020

Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells

scientific article published on September 2005

Acylation of lysine 983 is sufficient for toxin activity of Bordetella pertussis adenylate cyclase. Substitutions of alanine 140 modulate acylation site selectivity of the toxin acyltransferase CyaC.

scientific article published in January 2001

Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins

scientific article published on 27 May 2020

Adenylate cyclase toxin translocates across target cell membrane without forming a pore

scientific article published on 23 February 2010

Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines

scientific article published on 04 August 2014

Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin

scientific article published on 26 May 2021

An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis

scientific article

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

scientific article published on 14 July 2014

Biocompatible Size-Defined Dendrimer-Albumin Binding Protein Hybrid Materials as a Versatile Platform for Biomedical Applications

scientific article published on 8 January 2016

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.

scientific article

Bordetella adenylate cyclase toxin induces a cascade of morphological changes of sheep erythrocytes and localizes into clusters in erythrocyte membranes.

scientific article published in February 2006

Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

scientific article

Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two steps

scientific article published in May 2010

Bordetella adenylate cyclase toxin: a swift saboteur of host defense

scientific article

Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase

scientific article

Bordetella pertussis filamentous hemagglutinin itself does not trigger anti-inflammatory interleukin-10 production by human dendritic cells

scientific article published on 30 November 2015

Bordetella protein toxins

Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores

scientific article

Calcium-Driven Folding of RTX Domain β-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts

scientific article

Channel formation in model membranes by the adenylate cyclase toxin of Bordetella pertussis: effect of calcium

scientific article published in July 2003

Characterization of the flexible genome complement of the commensal Escherichia coli strain A0 34/86 (O83 : K24 : H31).

scientific article

Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid

scientific article published on 17 September 2008

Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses

scientific article published on July 2012

Crystallization and preliminary crystallographic characterization of the iron-regulated outer membrane lipoprotein FrpD from Neisseria meningitidis

scientific article published on 28 August 2010

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue

scientific article published on 10 August 2020

Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domain

scientific article

Detection of immune cell response to M. tuberculosis-specific antigens by quantitative polymerase chain reaction.

scientific article

Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size

scientific article

Different roles of conserved tyrosine residues of the acylated domains in folding and activity of RTX toxins

scientific article published on 06 October 2021

Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

scientific article published on 20 June 2019

Editorial – ETOX turned twenty

scientific article published in 2004

Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids

scientific article

Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector

scientific article

Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?

scientific article

Gliadin fragments promote migration of dendritic cells

scientific article published on April 2011

Hemolytic, but Not Cell-invasive Activity, of Adenylate Cyclase Toxin Is Selectively Affected by Differential Fatty-acylation in Escherichia coli ⬇️

scientific article published on September 1, 1995

Heterologous expression of full-length capsid protein of porcine circovirus 2 in Escherichia coli and its potential use for detection of antibodies

scientific article published on 5 August 2009

Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin

scientific article published on 02 October 2012

High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection

scientific article

High-level synthesis of active adenylate cyclase toxin of Bordetella pertussis in a reconstructed Escherichia coli system

scientific article published on 01 July 1991

HlyA knock out yields a safer Escherichia coli A0 34/86 variant with unaffected colonization capacity in piglets

scientific article published on 01 November 2006

Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells

scientific article

Identification by in vitro complementation of regions required for cell-invasive activity of Bordetella pertussis adenylate cyclase toxin

scientific article published on 01 September 1995

Identification of an inducible penicillinase of the lithoautotrophic hydrogen-oxidizing bacteriumAlcaligenes eutrophus

scientific article published on 01 January 1987

Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria

scientific article

In vitro activation of CMV-specific human CD8(+) T cells by adenylate cyclase toxoids delivering pp65 epitopes.

scientific article published on 28 March 2011

In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying multiple copies of a viral CD8(+) T-cell epitope

scientific article published on 01 November 1999

Increasing affinity of interferon-γ receptor 1 to interferon-γ by computer-aided design.

scientific article published on 2 October 2013

Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells.

scientific article published on 3 October 2012

Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis

scientific article published on 7 July 2010

Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin

scientific article published on January 2008

Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding

scientific article published on 29 December 2014

Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain

scientific article published on 28 July 2003

Interaction of Calcium withBordetella pertussisAdenylate Cyclase Toxin

scientific article published in Journal of Biological Chemistry

Intrinsically disordered enamel matrix protein ameloblastin forms ribbon-like supramolecular structures via an N-terminal segment encoded by exon 5

scientific article published on 19 June 2013

Membrane restructuring by Bordetella pertussis adenylate cyclase toxin, a member of the RTX toxin family

scientific article

Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells

scientific article published on October 2006

Neisseria meningitidis RTX protein FrpC induces high levels of serum antibodies during invasive disease: polymorphism of frpC alleles and purification of recombinant FrpC.

scientific article

Neisseria meningitidis RTX proteins are not required for virulence in infant rats

scientific article

Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration

scientific article published on 19 January 2012

Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G.

scientific article

Occurrence of IgA and IgG Autoantibodies to Calreticulin in Coeliac Disease and Various Autoimmune Diseases

scientific article published on 01 December 2000

Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin.

scientific article published on 5 May 2009

Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases

scientific article published on 01 August 2020

Phospholipase A activity of adenylate cyclase toxin?

scientific article published on 21 February 2018

Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells

scientific article published on 24 November 2017

Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells

scientific article published on 18 January 2013

Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: role of voltage and pH.

scientific article

Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells.

scientific article

Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes

scientific article published on April 2006

Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara

scientific article published on 27 October 2005

Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination

scientific article published in 2022

Production of Highly Active Recombinant Dermonecrotic Toxin of Bordetella Pertussis

scientific article published on 15 September 2020

Proteome analysis of Bordetella pertussis isolated from human macrophages

scientific article published on 9 February 2016

Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin

scientific article published on 9 January 2014

RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides

scholarly article

RTX proteins: a highly diverse family secreted by a common mechanism

scientific article

Rapid Purification of Endotoxin-Free RTX Toxins

scientific article published on 12 June 2019

Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis

scientific article

Redesigning protein cavities as a strategy for increasing affinity in protein-protein interaction: interferon- γ receptor 1 as a model

scientific article published on 28 April 2015

Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin

scientific article published on 08 April 2019

Retargeting from the CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzyme-translocating segment of Bordetella adenylate cyclase toxin

scientific article published on 11 May 2020

Segments Crucial for Membrane Translocation and Pore-forming Activity ofBordetellaAdenylate Cyclase Toxin

scientific article published in Journal of Biological Chemistry

Single-step affinity purification of recombinant proteins using a self-excising module from Neisseria meningitidis FrpC.

scientific article published on 28 July 2008

Specific regions of genome plasticity and genetic diversity of the commensal Escherichia coli A0 34/86.

scientific article published on 16 October 2006

The Bordetella pertussis Type III Secretion System Tip Complex Protein Bsp22 Is Not a Protective Antigen and Fails To Elicit Serum Antibody Responses during Infection of Humans and Mice.

scientific article published in July 2014

The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin ⬇️

scientific article published on September 1, 1995

The Conserved Lysine 860 in the Additional Fatty-acylation Site of Bordetella pertussis Adenylate Cyclase Is Crucial for Toxin Function Independently of Its Acylation Status

scientific article published in Journal of Biological Chemistry

The Neisseria meningitidis outer membrane lipoprotein FrpD binds the RTX protein FrpC.

scientific article published on 2 November 2004

The RNA Chaperone Hfq Is Required for Virulence of Bordetella pertussis.

scientific article published in July 2014

The RNA chaperone Hfq is required for virulence of Bordetella pertussis

scientific article published on 26 August 2013

The adenylate cyclase toxin from Bordetella pertussis--a novel promising vehicle for antigen delivery to dendritic cells

scientific article published on April 2004

The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin

scientific article published on 24 August 2017

The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C.

scientific article

Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activities

scientific journal article

Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing

scientific article published on 2 February 2006

Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia

scientific article published on 12 January 2012

cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity

scientific article published on 30 December 2016

cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.

scientific article

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