List of works - Antonella Caputo

A minimal isoform of the TMEM16A protein associated with chloride channel activity.

scientific article published on 30 May 2011

An attenuated herpes simplex virus type 1 (HSV1) encoding the HIV-1 Tat protein protects mice from a deadly mucosal HSV1 challenge

scientific article

Antiangiogenic, antitumoural and antimetastatic effects of two distamycin A derivatives with anti-HIV-1 Tat activity in a Kaposi's sarcoma-like murine model

scientific article published on 01 January 1999

BK Virus-Plasmid Expression Vector That Persists Episomally in Human Cells and Shuttles into Escherichia coli ⬇️

scientific article published on August 1, 1984

Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccines

scientific article

Candidate HIV-1 Tat vaccine development: from basic science to clinical trials

article

Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse

scientific article

Characterization of HIV-1 Tat proteins mutated in the transactivation domain for prophylactic and therapeutic application.

scientific article published on May 2001

Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 ΔV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin

article

Co-operation in cell transformation between BK virus and the human c-Harvey-ras oncogene

scientific article

Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243).

scientific article published in April 2009

Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine

article

Cooperation in oncogenesis between BK virus early region gene and the activated human c-Harvey ras oncogene.

scientific article

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins

scientific article published in January 2005

DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination

article

Dystrophin restoration in skeletal, heart and skin arrector pili smooth muscle of mdx mice by ZM2 NP-AON complexes

scientific article published on 12 November 2009

Effects of different routes of administration on the immunogenicity of the Tat protein and a Tat-derived peptide

scientific article published on June 2015

Episomal DNA of a BK virus variant in a human insulinoma.

scientific article published in January 1983

Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.

scientific article

Expression of human immunodeficiency virus type 1 tat from a replication-deficient herpes simplex type 1 vector induces antigen-specific T cell responses

scientific article published on 12 July 2006

First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.

scientific article published on 28 August 2014

Functional polymeric nano/microparticles for surface adsorption and delivery of protein and DNA vaccines.

scientific article published on October 2008

HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection

scientific article

HIV-1 Tat affects the programming and functionality of human CD8⁺ T cells by modulating the expression of T-box transcription factors.

scientific article published on July 2014

HIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development.

scientific article

HIV-1 Tat-based vaccines: from basic science to clinical trials

scientific article

HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity

scientific article published on September 2004

Identification of new HIV-1 Gag-specific cytotoxic T lymphocyte responses in BALB/c mice.

scientific article published on 14 July 2008

Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particles

scientific article

Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat.

scientific article

Induction of humoral and enhanced cellular immune responses by novel core-shell nanosphere- and microsphere-based vaccine formulations following systemic and mucosal administration

scientific article published on 7 April 2009

Inhibition of HIV-1 Tat activity correlates with down-regulation of bcl-2 and results in reduction of angiogenesis and oncogenicity.

scientific article published in July 2002

Inhibition of HIV-1 replication by a Tat transdominant negative mutant in human peripheral blood lymphocytes from healthy donors and HIV-1-infected patients ⬇️

scientific article published on November 1, 1997

Inhibition of human immunodeficiency virus reactivation from latency by a tat transdominant negative mutant.

scientific article published on December 1993

Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners

scientific article published on 01 May 2003

Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination.

scientific article

Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys.

scientific article published in September 2004

Micellar-type complexes of tailor-made synthetic block copolymers containing the HIV-1 tat DNA for vaccine application

scientific article

Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules

article

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.

scientific article published on April 1999

Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators.

scientific article published on 02 June 2009

Neutralizing and cross-neutralizing antibody titres induced by bivalent and quadrivalent human papillomavirus vaccines in the target population of organized vaccination programmes

scientific article published on 18 July 2014

Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application

scientific article published in July 2004

Oncogenity of BK virus for immunosuppressed hamsters.

scientific article published in January 1982

Preparation and Characterization of Innovative Protein-coated Poly(Methylmethacrylate) Core-shell Nanoparticles for Vaccine Purposes

scientific article published on 03 May 2007

Prevalence of liver tumours in HIV-1 tat-transgenic mice treated with urethane.

scientific article

Priming with a very low dose of DNA complexed with cationic block copolymers followed by protein boost elicits broad and long-lasting antigen-specific humoral and cellular responses in mice

scientific article published on 28 May 2009

Problems and emerging approaches in HIV/AIDS vaccine development

scientific article published on March 2007

Processing of retinal signals in normal and HCN deficient mice

scientific article

Recent advances in the development of HIV-1 Tat-based vaccines

scientific article

Reexamination of the coding potential of the HTLV-1 pX region.

scientific article

Regulation of TMEM16A chloride channel properties by alternative splicing

scientific article

Sequence conservation and antibody cross-recognition of clade B human immunodeficiency virus (HIV) type 1 Tat protein in HIV-1-infected Italians, Ugandans, and South Africans

scientific article published on 30 September 2003

Systemic immunodominant CD8 responses with an effector-like phenotype are induced by intravaginal immunization with attenuated HSV vectors expressing HIV Tat and mediate protection against HSV infection

scientific article published on 18 March 2016

TMEM16A is associated with voltage-gated calcium channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit

scientific article

TMEM16A protein: a new identity for Ca(2+)-dependent Cl⁻ channels

scientific article published on December 2010

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity

scientific article

The HIV-1 Tat protein affects human CD4+ T cell programming and activation, and favors the differentiation of naïve CD4+ T cells.

scientific article

The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses

scientific article

The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS

article

The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.

scientific article

The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice.

scientific article published on 25 September 2010

The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconverters

scientific article published on 14 March 2005

Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels

scientific article

Transcription pattern of human herpesvirus 8 open reading frame K3 in primary effusion lymphoma and Kaposi's sarcoma.

scientific article published in August 2001

Tumor-host interaction mediates the regression of BK virus-induced vascular tumors in mice: involvement of transforming growth factor-beta1.

scientific article published on 4 July 2003

Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant ΔV2 Env

article

List of works by Antonella Caputo

A minimal isoform of the TMEM16A protein associated with chloride channel activity.

An attenuated herpes simplex virus type 1 (HSV1) encoding the HIV-1 Tat protein protects mice from a deadly mucosal HSV1 challenge

Antiangiogenic, antitumoural and antimetastatic effects of two distamycin A derivatives with anti-HIV-1 Tat activity in a Kaposi's sarcoma-like murine model

BK Virus-Plasmid Expression Vector That Persists Episomally in Human Cells and Shuttles into Escherichia coli ⬇️

Biocompatible anionic polymeric microspheres as priming delivery system for effetive HIV/AIDS Tat-based vaccines

Candidate HIV-1 Tat vaccine development: from basic science to clinical trials

Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse

Characterization of HIV-1 Tat proteins mutated in the transactivation domain for prophylactic and therapeutic application.

Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 ΔV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin

Co-operation in cell transformation between BK virus and the human c-Harvey-ras oncogene

Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243).

Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine

Cooperation in oncogenesis between BK virus early region gene and the activated human c-Harvey ras oncogene.

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins

DNA prime and protein boost immunization with innovative polymeric cationic core-shell nanoparticles elicits broad immune responses and strongly enhance cellular responses of HIV-1 tat DNA vaccination

Dystrophin restoration in skeletal, heart and skin arrector pili smooth muscle of mdx mice by ZM2 NP-AON complexes

Effects of different routes of administration on the immunogenicity of the Tat protein and a Tat-derived peptide

Episomal DNA of a BK virus variant in a human insulinoma.

Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.

Expression of human immunodeficiency virus type 1 tat from a replication-deficient herpes simplex type 1 vector induces antigen-specific T cell responses

First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.

Functional polymeric nano/microparticles for surface adsorption and delivery of protein and DNA vaccines.

HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection

HIV-1 Tat affects the programming and functionality of human CD8⁺ T cells by modulating the expression of T-box transcription factors.

HIV-1 Tat-based vaccines: an overview and perspectives in the field of HIV/AIDS vaccine development.

HIV-1 Tat-based vaccines: from basic science to clinical trials

HIV-1 tat protein modulates the generation of cytotoxic T cell epitopes by modifying proteasome composition and enzymatic activity

Identification of new HIV-1 Gag-specific cytotoxic T lymphocyte responses in BALB/c mice.

Immobilized HIV-1 Tat protein promotes gene transfer via a transactivation-independent mechanism which requires binding of Tat to viral particles

Immunization with low doses of HIV-1 tat DNA delivered by novel cationic block copolymers induces CTL responses against Tat.

Induction of humoral and enhanced cellular immune responses by novel core-shell nanosphere- and microsphere-based vaccine formulations following systemic and mucosal administration

Inhibition of HIV-1 Tat activity correlates with down-regulation of bcl-2 and results in reduction of angiogenesis and oncogenicity.

Inhibition of HIV-1 replication by a Tat transdominant negative mutant in human peripheral blood lymphocytes from healthy donors and HIV-1-infected patients ⬇️

Inhibition of human immunodeficiency virus reactivation from latency by a tat transdominant negative mutant.

Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners

Interferon regulatory factor-1 acts as a powerful adjuvant in tat DNA based vaccination.

Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys.

Micellar-type complexes of tailor-made synthetic block copolymers containing the HIV-1 tat DNA for vaccine application

Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules

Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.

Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators.

Neutralizing and cross-neutralizing antibody titres induced by bivalent and quadrivalent human papillomavirus vaccines in the target population of organized vaccination programmes

Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application

Oncogenity of BK virus for immunosuppressed hamsters.

Preparation and Characterization of Innovative Protein-coated Poly(Methylmethacrylate) Core-shell Nanoparticles for Vaccine Purposes

Prevalence of liver tumours in HIV-1 tat-transgenic mice treated with urethane.

Priming with a very low dose of DNA complexed with cationic block copolymers followed by protein boost elicits broad and long-lasting antigen-specific humoral and cellular responses in mice

Problems and emerging approaches in HIV/AIDS vaccine development

Processing of retinal signals in normal and HCN deficient mice

Recent advances in the development of HIV-1 Tat-based vaccines

Reexamination of the coding potential of the HTLV-1 pX region.

Regulation of TMEM16A chloride channel properties by alternative splicing

Sequence conservation and antibody cross-recognition of clade B human immunodeficiency virus (HIV) type 1 Tat protein in HIV-1-infected Italians, Ugandans, and South Africans

Systemic immunodominant CD8 responses with an effector-like phenotype are induced by intravaginal immunization with attenuated HSV vectors expressing HIV Tat and mediate protection against HSV infection

TMEM16A is associated with voltage-gated calcium channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit

TMEM16A protein: a new identity for Ca(2+)-dependent Cl⁻ channels

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity

The HIV-1 Tat protein affects human CD4+ T cell programming and activation, and favors the differentiation of naïve CD4+ T cells.

The HIV-1 Tat protein induces the activation of CD8+ T cells and affects in vivo the magnitude and kinetics of antiviral responses

The Tat protein broadens T cell responses directed to the HIV-1 antigens Gag and Env: Implications for the design of new vaccination strategies against AIDS

The expression of P-glycoprotein is causally related to a less aggressive phenotype in human osteosarcoma cells.

The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice.

The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconverters

Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels

Transcription pattern of human herpesvirus 8 open reading frame K3 in primary effusion lymphoma and Kaposi's sarcoma.

Tumor-host interaction mediates the regression of BK virus-induced vascular tumors in mice: involvement of transforming growth factor-beta1.

Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant ΔV2 Env