List of works - Martijn Verdoes

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo

scientific article

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

scientific article published on 02 May 2022

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages

scientific article

A panel of subunit-selective activity-based proteasome probes

scientific article published on 6 May 2010

A practical synthesis of gramicidin s and sugar amino Acid containing analogues.

scientific article

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

scientific article published on 8 September 2007

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

scientific article

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

scientific article

An optimized activity-based probe for the study of caspase-6 activation

scientific article published in March 2012

An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S.

scientific article published in March 2004

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes

scientific article

Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling

scientific article published on July 2008

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells

scientific article

Chemical Tools To Study the Proteasome

article published in 2009

Chemical proteomics profiling of proteasome activity

scientific article published on January 2006

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

scientific article

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

scientific article

Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization

scientific article

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins

scientific article

Detection of protease activity in cells and animals.

scientific article published on 07 May 2015

Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides

scientific article published on 26 June 2014

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

scientific article published on 28 August 2019

Functional imaging of legumain in cancer using a new quenched activity-based probe

scientific article published on 18 December 2012

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes ⬇️

scientific article published on November 16, 2011

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

scientific article published on 04 March 2019

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

scientific article published on 12 July 2013

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity

scientific article published on 19 September 2013

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

scientific article

Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors

scientific article published on 23 March 2007

Nature of pharmacophore influences active site specificity of proteasome inhibitors

scientific article

New approaches for dissecting protease functions to improve probe development and drug discovery

scientific article

Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe

scientific article

O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes

scientific article

Proteasome activity imaging and profiling characterizes bacterial effector syringolin A

scientific article published on 02 November 2010

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities

scientific article published on 23 December 2009

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

scientific article published in January 2009

Regulation of immunoproteasome function in the lung

scientific article published on 19 May 2015

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.

scientific article published on 23 May 2013

Restoring immunosurveillance by dendritic cell vaccines and manipulation of the tumor microenvironment

scientific article

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

scientific article

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib

scientific article published on May 2011

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

scientific article

Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

Synthetic Semiflexible and Bioactive Brushes

scientific article published on 13 June 2019

TLR Agonist Conjugation: A Chemical Perspective

scientific article published on 29 January 2018

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

scientific article published on 14 February 2019

The right touch: design of artificial antigen-presenting cells to stimulate the immune system

article by Joep van der Weijden et al published 23 May 2014 in Chemical Science

The use of a mannitol-derived fused oxacycle as a combinatorial scaffold

scientific article published in November 2003

Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study

scientific article published on 23 June 2011

Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation

scientific article published on August 2010

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity

scientific article

List of works by Martijn Verdoes

A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages

A panel of subunit-selective activity-based proteasome probes

A practical synthesis of gramicidin s and sugar amino Acid containing analogues.

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

An optimized activity-based probe for the study of caspase-6 activation

An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S.

Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes

Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling

Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells

Chemical Tools To Study the Proteasome

Chemical proteomics profiling of proteasome activity

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization

Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins

Detection of protease activity in cells and animals.

Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

Functional imaging of legumain in cancer using a new quenched activity-based probe

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes ⬇️

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Improved quenched fluorescent probe for imaging of cysteine cathepsin activity

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.

Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors

Nature of pharmacophore influences active site specificity of proteasome inhibitors

New approaches for dissecting protease functions to improve probe development and drug discovery

Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe

O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes

Proteasome activity imaging and profiling characterizes bacterial effector syringolin A

Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities

Receptor-mediated targeting of cathepsins in professional antigen presenting cells

Regulation of immunoproteasome function in the lung

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS.

Restoring immunosurveillance by dendritic cell vaccines and manipulation of the tumor microenvironment

Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib

Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.

Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

Synthetic Semiflexible and Bioactive Brushes

TLR Agonist Conjugation: A Chemical Perspective

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

The right touch: design of artificial antigen-presenting cells to stimulate the immune system

The use of a mannitol-derived fused oxacycle as a combinatorial scaffold

Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study

Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation

Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity