List of works - Lars C Pedersen

( R )-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase β

scientific article

100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology

scientific article

3'-Phosphoadenosine 5'-phosphosulfate binding site of flavonol 3-sulfotransferase studied by affinity chromatography and 31P NMR

scientific article published on 01 March 1999

A Structural Basis for Biguanide Activity.

scientific article

A closed conformation for the Pol lambda catalytic cycle.

scientific article

A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda.

scientific article published on 26 June 2008

A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate

scientific article

A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.

scientific article

A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1

scientific article published on 10 July 2019

Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.

scientific article

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

scientific article

Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis

scientific article

Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity

scientific article

Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity

scientific article

Characterization of an anti-Bla g 1 scFv: Epitope mapping and cross-reactivity

scientific article

Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications

scientific article published on 20 October 2017

Creative template-dependent synthesis by human polymerase mu.

scientific article

Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms

scientific article

Crystallographic analysis and mimicking of estradiol binding: Pedersen et al. Respond

scientific article published on April 2014

Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase.

scientific article

DNA Polymerase Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"

scientific article

Der p 5 Crystal Structure Provides Insight into the Group 5 Dust Mite Allergens

scientific article

Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity.

scientific article

Energy analysis of chemistry for correct insertion by DNA polymerase beta

scholarly article

Engineering sulfotransferases to modify heparan sulfate

scientific article

Functional residues on the surface of the N-terminal domain of yeast Pms1

scientific article

Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography

scientific article

Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay

scientific article published on 26 September 2012

Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation

scientific article published on 13 November 2017

Ligand binding characteristics of the Ku80 von Willebrand domain

scientific article published on 24 October 2019

Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

scientific article published on April 2006

Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta

scientific article

Molecular determinants of the stereoselectivity of agonist activity of estrogen receptors (ER) alpha and beta

scientific article published on 22 January 2003

Mouse steroid sulfotransferases: substrate specificity and preliminary X-ray crystallographic analysis.

scientific article published in February 1998

Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.

scientific article

Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse

scientific article

Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS

scientific article

Probing Dominant Negative Behavior of Glucocorticoid Receptor β through a Hybrid Structural and Biochemical Approach.

scientific article published on 5 February 2018

Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis

scientific article

Replication infidelity via a mismatch with Watson–Crick geometry

scientific article

Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate

scientific article

Role of the catalytic metal during polymerization by DNA polymerase lambda

scientific article

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation

scientific article

Serological, genomic and structural analyses of the major mite allergen Der p 23.

scientific article published on 25 November 2015

Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction

scientific article

Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions

scientific article published on 28 February 2019

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

scientific article published on September 2017

Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum

scientific article

Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase

scientific article published on 01 January 2006

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification

scientific article published on 13 May 2016

Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes

scientific article published on 11 March 2016

Structural characterization of the virulence factor nuclease A from Streptococcus agalactiae

scientific article

Structural determinants of the bifunctional corn Hageman factor inhibitor: x-ray crystal structure at 1.95 A resolution

scientific article

Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII ⬇️

scientific article published on June 1, 1995

Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.

scientific article published on 19 September 2005

Structural insight into the substrate specificity of DNA Polymerase mu

scientific article

Structural insights into the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena.

scientific article published on 15 May 2005

Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase ⬇️

scientific article published on October 17, 1995

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break

scientific article published on 22 September 2020

Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases.

scientific article

Structure and function studies of factor XIIIa by x-ray crystallography

scientific article published on 01 January 1996

Structure of a signal transduction regulator, RACK1, fromArabidopsis thaliana

scientific article

Structure-function analysis of ribonucleotide bypass by B family DNA replicases

scientific article

Structure-function studies of DNA polymerase lambda.

scientific article

Structure-function studies of DNA polymerase λ

scientific article

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

scientific article

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

scientific article

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

scientific article published on 6 July 2018

Substrate gating confers steroid specificity to estrogen sulfotransferase.

scientific article published in October 1999

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ

scientific article

Sustained active site rigidity during synthesis by human DNA polymerase μ

scientific article

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid ⬇️

scientific article published on August 19, 2010

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

scientific article published on 23 August 2009

The X family portrait: structural insights into biological functions of X family polymerases.

scientific article

The catalytic cycle for ribonucleotide incorporation by human DNA Pol

scientific article

The corn inhibitor of blood coagulation factor XIIa. Crystallization and preliminary crystallographic analysis

scientific article published on 01 February 1994

The molecular basis of peanut allergy

scientific article published on May 2014

The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α

scientific article published on 18 January 2013

The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment

scientific article

The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.

scientific article

The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins

scientific article

The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis

scientific article

Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.

scientific article

Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII

scientific article

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action

scientific article published on 15 August 2017

Understanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approach

scientific article

Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine

scientific article published on 01 September 2019

Unfolding the HIV-1 reverse transcriptase RNase H domain--how to lose a molecular tug-of-war

scientific article published on 14 January 2016

Using engineered 6-O-sulfotransferase to improve the synthesis of anticoagulant heparin ⬇️

scientific article published on 07 October 2020

Variations in nuclear localization strategies among pol X family enzymes

scientific article published on 22 June 2018

α,β-Difluoromethylene Deoxynucleoside 5′-Triphosphates: A Convenient Synthesis of Useful Probes for DNA Polymerase β Structure and Function

scientific article

List of works by Lars C Pedersen

( R )-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase β

100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology

3'-Phosphoadenosine 5'-phosphosulfate binding site of flavonol 3-sulfotransferase studied by affinity chromatography and 31P NMR

A Structural Basis for Biguanide Activity.

A closed conformation for the Pol lambda catalytic cycle.

A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda.

A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate

A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.

A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1

Activation-induced deoxycytidine deaminase: Structural basis for favoring WRC hot motif specificities unique among APOBEC family members.

Amino Acid Substitution in the Active Site of DNA Polymerase β Explains the Energy Barrier of the Nucleotidyl Transfer Reaction

Analysis of glutathione S-transferase allergen cross-reactivity in a North American population: Relevance for molecular diagnosis

Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity

Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity

Characterization of an anti-Bla g 1 scFv: Epitope mapping and cross-reactivity

Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications

Creative template-dependent synthesis by human polymerase mu.

Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms

Crystallographic analysis and mimicking of estradiol binding: Pedersen et al. Respond

Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase.

DNA Polymerase Substrate Specificity: SIDE CHAIN MODULATION OF THE"A-RULE"

Der p 5 Crystal Structure Provides Insight into the Group 5 Dust Mite Allergens

Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity.

Energy analysis of chemistry for correct insertion by DNA polymerase beta

Engineering sulfotransferases to modify heparan sulfate

Functional residues on the surface of the N-terminal domain of yeast Pms1

Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography

Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay

Interaction of the phosphorylated DNA-binding domain in nuclear receptor CAR with its ligand-binding domain regulates CAR activation

Ligand binding characteristics of the Ku80 von Willebrand domain

Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta

Molecular determinants of the stereoselectivity of agonist activity of estrogen receptors (ER) alpha and beta

Mouse steroid sulfotransferases: substrate specificity and preliminary X-ray crystallographic analysis.

Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.

Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse

Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS

Probing Dominant Negative Behavior of Glucocorticoid Receptor β through a Hybrid Structural and Biochemical Approach.

Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis

Replication infidelity via a mismatch with Watson–Crick geometry

Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan Sulfate

Role of the catalytic metal during polymerization by DNA polymerase lambda

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation

Serological, genomic and structural analyses of the major mite allergen Der p 23.

Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction

Structural Analysis of Recent Allergen-Antibody Complexes and Future Directions

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu.

Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum

Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification

Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes

Structural characterization of the virulence factor nuclease A from Streptococcus agalactiae

Structural determinants of the bifunctional corn Hageman factor inhibitor: x-ray crystal structure at 1.95 A resolution

Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII ⬇️

Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.

Structural insight into the substrate specificity of DNA Polymerase mu

Structural insights into the mechanism of nuclease A, a betabeta alpha metal nuclease from Anabaena.

Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase ⬇️

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break

Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases.

Structure and function studies of factor XIIIa by x-ray crystallography

Structure of a signal transduction regulator, RACK1, fromArabidopsis thaliana

Structure-function analysis of ribonucleotide bypass by B family DNA replicases

Structure-function studies of DNA polymerase lambda.

Structure-function studies of DNA polymerase λ

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism

Structures of DNA Polymerase β with Active-Site Mismatches Suggest a Transient Abasic Site Intermediate during Misincorporation

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Substrate gating confers steroid specificity to estrogen sulfotransferase.

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ

Sustained active site rigidity during synthesis by human DNA polymerase μ

Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid ⬇️

Template strand scrunching during DNA gap repair synthesis by human polymerase lambda.

The X family portrait: structural insights into biological functions of X family polymerases.

The catalytic cycle for ribonucleotide incorporation by human DNA Pol

The corn inhibitor of blood coagulation factor XIIa. Crystallization and preliminary crystallographic analysis

The molecular basis of peanut allergy

The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α

The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment