List of works - X. Long Zheng

A novel association of acquired ADAMTS13 inhibitor and acute dengue virus infection

scientific article

A team player: the disintegrin domain of ADAMTS13

scientific article published on 01 May 2009

AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura ⬇️

scientific article published on March 20, 2013

ADAMTS13 and TTP

scientific article (publication date: September 2002)

ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura

scientific article

ADAMTS13 and von Willebrand factor interactions

scientific article

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro

scientific article

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model

scientific article

ADAMTS13 meets MR, then what? ⬇️

scientific article published on April 19, 2012

ADAMTS13 test and/or PLASMIC clinical score in management of acquired thrombotic thrombocytopenic purpura: a cost-effective analysis.

scientific article

ADAMTS13 testing: why bother?

scientific article published on 01 February 2010

ADAMTS13, TTP and Beyond

scientific article published on January 2013

ADAMTS13, lucky to have a hydrophobic pocket

scientific article published on March 2015

Acquired autoimmune thrombotic thrombocytopenic purpura in a case of severe haemophilia A.

scientific article published on 5 October 2016

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C ⬇️

scientific article published on May 15, 1998

Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.

scientific article

An evaluation of cyclosporine alone for the treatment of early recurrences of thombotic thrombocytopenic purpura

scientific article published on 01 May 2006

Analysis of morphology of platelet aggregates formed on collagen under laminar blood flow

scientific article published on 15 October 2010

Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura.

scientific article published on 14 February 2014

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

scientific article

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

scientific article published on January 1999

Apolipoprotein B100/Low-Density Lipoprotein Regulates Proteolysis and Functions of von Willebrand Factor under Arterial Shear

scientific article published on 07 September 2019

Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway.

scientific article published on 29 September 2013

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

scholarly article

Biochemistry and physiological functions of ADAMTS7 metalloprotease

scientific article published on January 2013

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

scientific article published in December 1997

Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner

scientific article

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

scientific article published in Journal of Biological Chemistry

Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.

scientific article published on 5 June 2003

Compromised shear-dependent cleavage of type 2N von Willebrand factor variants by ADAMTS13 in the presence of factor VIII.

scientific article published on 2 May 2013

Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity: comment.

scientific article published on 5 January 2017

Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura.

scientific article

DNase, ADAMTS13, and iPAD4: good for the heart.

scientific article published on January 2014

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

scientific article

Effect of protein C inhibitor (PCI) on in vitro fertilization

scientific article published on 01 June 1996

Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri

scientific article published on 01 May 1997

Enteropeptidase, a type II transmembrane serine protease.

scientific article published on June 2009

Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis.

scientific article published on 28 July 2011

Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura

scientific article published on 12 November 2020

Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis

scientific article

Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development.

scientific article published on 27 July 2017

Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor

scientific article published on 16 June 2020

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.

scientific article

Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.

scientific article

Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura

scientific article published on 04 August 2020

High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.

scientific article

Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura

scientific article

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

scientific article published on 13 May 2016

ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura

scientific article published on 17 July 2020

ISTH guidelines for treatment of thrombotic thrombocytopenic purpura

scientific article published on 15 July 2020

Identification of cysteine thiol-based linkages in ADAMTS13 in support of a non-proteolytic regulation of von Willebrand factor

scientific article published on 03 September 2019

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

scientific article published on June 1998

Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa ⬇️

scientific article published on August 1, 1994

Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time.

scientific article

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice

scientific article

Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

scientific article published on 18 June 2009

Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease ⬇️

scientific article published on September 21, 2012

Longitudinal assessments of plasma ADAMTS13 biomarkers predict recurrence of immune thrombotic thrombocytopenic purpura

scientific article published on 01 December 2019

Low Plasma ADAMTS13 Activity Is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Paediatric Trauma.

scientific article published on 4 April 2018

Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literature.

scientific article published on 11 December 2017

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

scientific article

Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.

scientific article

Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma

scientific article published on 01 July 2017

Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus

scientific article published on 01 April 1997

Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.

scientific article published on 17 October 2016

Novel recombinant glycosylphosphatidylinositol (GPI)-anchored ADAMTS13 and variants for assessment of anti-ADAMTS13 autoantibodies in patients with thrombotic thrombocytopenic purpura ⬇️

scientific article published on September 8, 2011

Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid haemorrhage.

scientific article published on 19 January 2017

Plasma levels of S100A8/A9, histone/DNA complexes, and cell-free DNA predict adverse outcomes of immune thrombotic thrombocytopenic purpura

scientific article published on 14 November 2020

Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation

scientific article published on 11 August 2017

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

scientific article

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

scientific article

Protein C inhibitor (PCI)

scientific article

Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development ⬇️

scientific article published on February 1, 1998

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

scientific article published on 13 August 2019

The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.

scientific article published on 23 June 2005

Thromboelastography of patients after fontan compared with healthy children.

scientific article published on 09 April 2009

Thrombotic Thrombocytopenic Purpura: Pathogenesis, Diagnosis, and Potential Novel Therapeutics

scientific article

Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR).

scientific article

Ticlopidine-associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR).

scientific article

Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease.

scientific article published on 23 April 2015

Understanding thrombotic microangiopathies in children

scientific article published on 24 January 2018

[Research advances on ADAM28 expression and ADAM28-mediated tumor metastasis]

scientific article published on 01 August 2014

von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size.

scientific article published on 11 August 2009

List of works by X. Long Zheng

A novel association of acquired ADAMTS13 inhibitor and acute dengue virus infection

A team player: the disintegrin domain of ADAMTS13

AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura ⬇️

ADAMTS13 and TTP

ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura

ADAMTS13 and von Willebrand factor interactions

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 1. Structural and functional characterization in vitro

ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model

ADAMTS13 meets MR, then what? ⬇️

ADAMTS13 test and/or PLASMIC clinical score in management of acquired thrombotic thrombocytopenic purpura: a cost-effective analysis.

ADAMTS13 testing: why bother?

ADAMTS13, TTP and Beyond

ADAMTS13, lucky to have a hydrophobic pocket

Acquired autoimmune thrombotic thrombocytopenic purpura in a case of severe haemophilia A.

Activation of Thrombin-activable Fibrinolysis Inhibitor Requires Epidermal Growth Factor-like Domain 3 of Thrombomodulin and Is Inhibited Competitively by Protein C ⬇️

Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.

An evaluation of cyclosporine alone for the treatment of early recurrences of thombotic thrombocytopenic purpura

Analysis of morphology of platelet aggregates formed on collagen under laminar blood flow

Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura.

Antigen and substrate withdrawal in the management of autoimmune thrombotic disorders.

Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts.

Apolipoprotein B100/Low-Density Lipoprotein Regulates Proteolysis and Functions of von Willebrand Factor under Arterial Shear

Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway.

Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.

Biochemistry and physiological functions of ADAMTS7 metalloprotease

Bovine proenteropeptidase is activated by trypsin, and the specificity of enteropeptidase depends on the heavy chain

Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner

Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.

Compromised shear-dependent cleavage of type 2N von Willebrand factor variants by ADAMTS13 in the presence of factor VIII.

Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity: comment.

Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura.

DNase, ADAMTS13, and iPAD4: good for the heart.

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.

Effect of protein C inhibitor (PCI) on in vitro fertilization

Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri

Enteropeptidase, a type II transmembrane serine protease.

Essential domains of a disintegrin and metalloprotease with thrombospondin type 1 repeats-13 metalloprotease required for modulation of arterial thrombosis.

Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura

Exploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosis

Expression of ADAMTS13 in Normal and Abnormal Placentae and Its Potential Role in Angiogenesis and Placenta Development.

Factor VIII binding affects the mechanical unraveling of the A2 domain of von Willebrand factor

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.

Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.

Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura

High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.

Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura

ISTH guidelines for treatment of thrombotic thrombocytopenic purpura

Identification of cysteine thiol-based linkages in ADAMTS13 in support of a non-proteolytic regulation of von Willebrand factor

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa ⬇️

Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time.

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice

Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease ⬇️

Longitudinal assessments of plasma ADAMTS13 biomarkers predict recurrence of immune thrombotic thrombocytopenic purpura

Low Plasma ADAMTS13 Activity Is Associated with Coagulopathy, Endothelial Cell Damage and Mortality after Severe Paediatric Trauma.

Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literature.

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

Murine systemic thrombophilia and hemolytic uremic syndrome from a factor H point mutation.

Mutations in Coagulation Factor VIII Are Associated with More Favorable Outcome in Patients with Cutaneous Melanoma

Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus

Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.

Novel recombinant glycosylphosphatidylinositol (GPI)-anchored ADAMTS13 and variants for assessment of anti-ADAMTS13 autoantibodies in patients with thrombotic thrombocytopenic purpura ⬇️

Plasma ADAMTS13 activity and von Willebrand factor antigen and activity in patients with subarachnoid haemorrhage.

Plasma levels of S100A8/A9, histone/DNA complexes, and cell-free DNA predict adverse outcomes of immune thrombotic thrombocytopenic purpura

Plasma levels of complement activation fragments C3b and sC5b-9 significantly increased in patients with thrombotic microangiopathy after allogeneic stem cell transplantation

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models.

Protein C inhibitor (PCI)

Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development ⬇️

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.

Thromboelastography of patients after fontan compared with healthy children.

Thrombotic Thrombocytopenic Purpura: Pathogenesis, Diagnosis, and Potential Novel Therapeutics

Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20-year review from the Southern Network on Adverse Reactions (SONAR).

Ticlopidine-associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR).