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List of works by Francisco Gamarro

4-amino bis-pyridinium derivatives as novel antileishmanial agents.

scientific article published on 5 May 2014

A new ABC half-transporter in Leishmania major is involved in resistance to antimony.

scientific article published on 28 May 2013

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania

scientific article published on 23 January 2011

A new member of YER057c family in Trypanosoma cruzi is adjacent to an ABC-transporter.

scientific article published in October 1998

A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids

scientific article published in June 2007

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

scientific article published on December 1997

ABC transporters in the protozoan parasite Leishmania.

scientific article

ABCI3 Is a New Mitochondrial ABC Transporter from Leishmania major Involved in Susceptibility to Antimonials and Infectivity.

scientific article

Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator

scientific article

All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae

scientific article published on 2 July 2008

Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line.

scientific article

Amplification of the H locus in Leishmania infantum.

scientific article published on November 1994

Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine.

scientific article published in January 2011

Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine

scientific article

Arylthiosemicarbazones as antileishmanial agents

scientific article published on 14 July 2016

Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance

scientific article published on 12 September 2007

Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.

scientific article

CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells

scientific article

Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

scientific article published on October 2004

Characterisation of Leishmania donovani promastigotes resistant to hexadecylphosphocholine (miltefosine).

scientific article

Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.

scientific article published on December 1999

Characterization of an ABCA-like transporter involved in vesicular trafficking in the protozoan parasite Trypanosoma cruzi.

scientific article published in November 2004

Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movement

scientific article published on 21 July 2008

Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis.

scientific article

Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux

scientific article

Correction: LABCG2, a New ABC Transporter Implicated in Phosphatidylserine Exposure, Is Involved in the Infectivity and Pathogenicity of Leishmania.

scientific article published on 12 June 2013

Decreased antimony uptake and overexpression of genes of thiol metabolism are associated with drug resistance in a canine isolate of Leishmania infantum.

scientific article published on 4 June 2016

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

scientific article

Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

scientific article

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

scientific article

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion

scientific article

Drug resistance and treatment failure in leishmaniasis: A 21st century challenge.

scientific article

Effect of interferon on the infectivity of Trypanosoma cruzi in cultured heLa cells

scientific article published on 01 April 1985

Effect of poly-l-lysine and neuraminidase on the infectivity ofTrypanosoma cruzi in cultured HeLa cells

scientific article published on 01 January 1985

Effet des enzymes protéolytiques sur la pénétration duTrypanosoma cruzidans les macrophages péritonéaux de souris

Evolutionary relationships in Trypanosoma cruzi: molecular phylogenetics supports the existence of a new major lineage of strains

scientific article published in April 2000

Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.

scientific article

Fitness of Leishmania donovani parasites resistant to drug combinations

scientific article (publication date: April 2015)

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

scientific article published on June 2005

Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance

scientific article published on 27 September 2003

Functional expression of a multidrug P-glycoprotein transporter of Leishmania

scientific article

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of the Leishmania miltefosine transporter-Cdc50 subunit

scientific article published on 01 April 2014

Functional role of highly-conserved residues of the N-terminal tail and first transmembrane segment of a P4-ATPase.

scientific article published on 7 February 2018

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

scientific article

High-affinity binding of silybin derivatives to the nucleotide-binding domain of a Leishmania tropica P-glycoprotein-like transporter and chemosensitization of a multidrug-resistant parasite to daunomycin

scientific article

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

scientific article

Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening

scientific article published on 14 October 2013

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

scientific article

Increased P-Type ATPase Activity in Leishmania tropica Resistant to Methotrexate

scientific article published on 01 March 1994

Increased glycolytic ATP synthesis is associated with tafenoquine resistance in Leishmania major

scientific article published on 3 January 2011

Inhibition of lysosomal fusion by Trypanosoma cruzi in peritoneal macrophages

scientific article published on 01 December 1986

Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

scientific article published on 11 January 2006

Isolation and purification of amastigotes ofTrypanosoma cruzi from cultured Vero cells

scientific article published on 01 January 1985

LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania

scientific article

Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy.

scientific article

Leishmania LABCG2 transporter is involved in ATP-dependent transport of thiols

scientific article

Leishmania donovani develops resistance to drug combinations

scientific article

Leishmania donovani resistance to miltefosine involves a defective inward translocation of the drug

scientific article published on August 2003

Leishmanicidal and Reversal Multidrug Resistance Constituents fromAeonium lindleyi

scientific article published on 21 July 2010

Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug

scientific article published on 2 February 2009

Mechanisms of action of substituted β-amino alkanols on Leishmania donovani.

scientific article

Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.

scientific article published on February 2006

Molecular characterization of a P-glycoprotein-related tcpgp2 gene in Trypanosoma cruzi.

scientific article

New Antiparasitic Agents

scientific article published on 01 January 1988

New Natural Sesquiterpenes as Modulators of Daunomycin Resistance in a Multidrug-ResistantLeishmaniatropicaLine‖,⊥

scientific article published on 01 October 1999

New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania

scientific article published on 26 November 2007

Non-reducing trisaccharide fatty acid monoesters: Novel detergents in membrane biochemistry

scientific article published on 03 December 2010

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

scientific article published on 11 July 2017

Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance

scientific article published on 15 October 2009

Optimization by Molecular Fine Tuning of Dihydro-β-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.

scientific article published on 2 February 2016

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes

scientific article

Oxazolo[3,2-a]pyridine. A new structural scaffold for the reversal of multi-drug resistance in Leishmania

scientific article published on 10 August 2012

Phospholipid translocation and miltefosine potency require both L. donovani miltefosine transporter and the new protein LdRos3 in Leishmania parasites.

scientific article published on 19 June 2006

Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity

scientific article published in February 2001

Purification of a glycoprotein excreted by Trypanosomacruzi to increase the permeability of the host-cell membrane

scientific article published on 01 January 1990

Purification of metacyclic forms ofTrypanosoma cruzi by Percoll discontinuous gradient centrifugation

scientific article published on 01 January 1984

RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance

scientific article published on March 2003

Rapid transport of phospholipids across the plasma membrane of Leishmania infantum

scientific article

Resistance to reinfection of HeLa cells parasitized by Trypanosoma cruzi

scientific article published on 01 October 1984

Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola

scientific article published on 19 February 2015

Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis

scientific article

SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.

scientific article

Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.

scientific article published on 6 June 2011

Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

scientific article published on 15 September 2008

Some factors affecting the in vitro invasion of HeLa cells by Trypanosoma cruzi

scientific article published on 01 June 1984

Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis

scientific article published on 13 September 2010

Terpenoids from Maytenus Species and Assessment of Their Reversal Activity against a Multidrug-Resistant Leishmania tropica Line ⬇️

scientific article published on 01 December 2011

The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase

scientific article

The Different Behavior of Diphtheria Toxin, Modeccin and Ricin in HeLa Cells Infected with Trypanosoma cruzi

scientific article published on 01 May 1994

The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance.

scientific article

The Oral Antimalarial Drug Tafenoquine Shows Activity against Trypanosoma brucei

scientific article

The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.

scientific article published on 25 October 2007

The invasion mechanism of the metacyclic forms of Trypanosoma cruzi in nonphagocytic host cells

article by A Osuna et al published 1993 in Biological Research

The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.

scientific article published in June 2003

The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in Leishmania

scientific article

Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme.

scientific article

Trypanosoma cruzi: Calcium ion movement during internalization in host HeLa cells

scientific article published on 01 August 1990

Trypanosoma cruzi: Molecular Cloning of a Gene Coding for a Putative Vacuolar Protein

article

Trypanosoma cruzi: sequence of the ATP-binding site of a P-glycoprotein gene.

scientific article published on August 1994

Two casein kinase 1 isoforms are differentially expressed in Trypanosoma cruzi.

scientific article published in September 2002

Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents

scientific article

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

scientific article published on 16 August 2011

[Ultrastructural study of the effect of 2 derivatives benzo (de) isoquinoline-1,3-dione on Trypanosoma cruzi in vitro]

scientific article published on 01 May 1983

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