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List of works by Mattia Bonsignori

A Multi-Vector, Multi-Envelope HIV-1 Vaccine

scientific article

A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization

scientific article published in 2022

A combination of 5-fluorouracil and membrane-bound antibody inhibits B-cell lymphoma growth in a mouse model system

scientific article published on 01 February 2007

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

scientific article published on 19 March 2018

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

scientific article

Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth

scientific article published on 20 January 2020

Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity

scientific article published on 31 August 2016

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

scientific article published on 10 March 2014

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

scientific article

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved

scientific article

Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family

scientific article

Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development

scientific article published on January 2017

Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion

scientific article published on 21 November 2012

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

scientific article published on 01 January 2019

Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity

scientific article published on 19 February 2014

Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary?

scientific article

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies

scientific article

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 02 December 2019

Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120.

scientific article published on 21 August 2017

Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

scientific article published on 01 July 2019

Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells

scientific article

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

scientific article

Epitope specificity of human immunodeficiency virus-1 antibody dependent cellular cytotoxicity [ADCC] responses

scientific article published on July 2013

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

scientific article

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site

scientific article published on 8 March 2018

Flow cytometry-based assay to study HIV-1 gp120 specific antibody-dependent cellular cytotoxicity responses.

scientific article published on 12 August 2014

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development

scientific article published on 31 May 2018

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.

scientific article published on 16 March 2018

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

scientific article published on 30 January 2020

HIV vaccine rationale, design and testing.

scientific article

HIV vaccines: brief review and discussion of future directions.

scientific article

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

article

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

scientific article published on 01 August 2019

HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design

scientific article

HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after envelope gp120 protein vaccination or HIV-1 infection

scientific article

HIV-1 specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galcer Blocking and Phagocytosis

scientific article published on 10 January 2018

HIV-1 vaccine development: tackling virus diversity with a multi-envelope cocktail.

scientific article published on January 2008

HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities

scientific article

Immune checkpoint modulation enhances HIV-1 antibody induction

scientific article published on 19 February 2020

Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020

scientific article published on 20 November 2020

Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccinees

scientific article published on 08 May 2013

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

article

Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses

scientific article published on 18 January 2017

Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations ⬇️

scientific article published on 23 November 2017

Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity

scientific article published on 18 December 2013

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

scientific article

Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials

scientific article

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

scientific article published on March 2017

Multi-Envelope HIV-1 Vaccine Development: Two Targeted Immune Pathways, One Desired Protective Outcome.

scientific article published on 9 January 2018

Multi-envelope HIV-1 vaccine devoid of SIV components controls disease in macaques challenged with heterologous pathogenic SHIV.

scientific article published on 20 July 2005

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

scientific article

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 17 September 2019

P04-01. Simultaneous enumeration of HIV-1 gp41 Env-specific IgG and IgM antibody-secreting cells with a multiplex B-cell fluorospot assay.

scientific article published on 22 October 2009

P04-48. HIV-1 envelope induces memory B cell responses that correlate with plasma antibody levels after gp120 protein vaccination or chronic HIV-1 infection

article

Polyreactivity and autoreactivity among HIV-1 antibodies

scientific article

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

scientific article published on January 2017

Prevalence and characterization of metallo-beta-lactamases in clinical isolates of pseudomonas aeruginosa.

scientific article published in February 2004

Progress in HIV-1 vaccine development.

scientific article

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial

scientific article published on 30 June 2020

Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.

scientific article published on 21 October 2013

Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

scientific article published in Nature Communications

Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

scientific article

Simultaneous Detection of Antigen-Specific IgG- and IgM-Secreting Cells with a B Cell Fluorospot Assay

scientific article published on 21 March 2012

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

scientific article published on March 2017

Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses

scientific article

Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee

scientific article published on 20 June 2015

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates

scientific article published on 04 June 2021

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

scientific article

Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques

scientific article published on 08 December 2016

Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design

scientific article published in February 2012

Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates

scientific article

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

scientific article

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models

scientific article published in December 2017

Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide

scientific article

Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.

scientific article published on 9 May 2013

Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?

scientific article published on 12 July 2014

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