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List of works by Albena Dinkova-Kostova

(+)-Pinoresinol/(+)-lariciresinol reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase ⬇️

scientific article

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

scientific article published on 01 November 2018

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

scientific article published on 17 January 2008

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

scientific article published on August 2008

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity

scientific article published on 17 May 2017

Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases

scientific article published on 01 April 2017

Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones

scientific article

Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease

scientific article published on 18 July 2020

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

scientific article

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

scientific article published on 09 November 2020

Assessment of ROS Production in the Mitochondria of Live Cells

scientific article published on 01 January 2021

Author Correction: Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

scientific article published in March 2018

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder

scientific article published on 02 April 2020

Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway

scientific article published on 6 March 2006

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

scientific article published on 06 October 2019

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.

scientific article published on 23 May 2018

Can Activation of NRF2 Be a Strategy against COVID-19?

scientific article published on 14 July 2020

Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

scientific article published on 14 August 2010

Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity.

scientific article published on 16 July 2008

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

scientific article

Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders

scientific article

Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

scientific article published on January 2004

Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids

scientific article

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms ⬇️

scientific article published on January 1, 2013

Chemoprotection against cancer: an idea whose time has come

scientific article published on March 2007

Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers

scientific article published on 01 December 1998

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

scientific article

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

scientific article published on 14 May 2021

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

scholarly article

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

scientific article published on 23 July 2009

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses.

scientific article published on 10 July 2017

Curcumin and the cellular stress response in free radical-related diseases.

scientific article published on September 2008

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1-Nrf2 Protein-Protein Interaction

scientific article published on 8 September 2015

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

scientific article published on April 2010

Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells

scientific article published on 26 February 2013

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

scientific article published on June 2008

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

scientific article (publication date: 3 September 2002)

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

scientific article published on 06 October 2020

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

scientific article published on 03 August 2015

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

scientific article

Electrophilic tuning of the chemoprotective natural product sulforaphane.

scientific article

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions.

scientific article

Erratum to “Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans” [Clin. Chim. Acta 316 (2002) 43–53]

scholarly article published in Clinica Chimica Acta

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

scientific article published on 13 December 2017

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

scientific article

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

scientific article published on 29 January 2016

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.

scientific article

Glucosinolates and isothiocyanates in health and disease.

scientific article

Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy

scientific article published on 09 January 2012

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway

scientific article

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

scientific article published on 27 June 2016

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

scientific article published on 25 September 2020

Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy

scientific article

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

scientific article

Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols

scientific article published on 21 September 2010

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

scientific article

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

scientific article published on 13 March 2019

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

scientific article published on 22 August 2020

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

scientific article published on 28 March 2018

KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane

scientific article published on 16 February 2017

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

scientific article published on 12 March 2018

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

scientific article published on 24 June 2020

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

scientific article

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.

scientific article

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

scientific article published in May 2005

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

scientific article published on 24 May 2016

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

scientific article published on 13 November 2009

Measuring Changes in Keap1-Nrf2 Protein Complex Conformation in Individual Cells by FLIM-FRET

scientific article published on 01 September 2020

Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

scientific article published on 11 March 2019

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

scientific article

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

scientific article published on 8 September 2017

Monitoring Keap1-Nrf2 interactions in single live cells

scientific article published on 25 March 2014

NAD(P)H : quinone oxidoreductase 1 inducer activity of some Saudi Arabian medicinal plants

scientific article published on 19 March 2013

NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives

scientific article published on 21 January 2016

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

scientific article

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives

scientific article published on 08 August 2016

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

scientific article published on 02 December 2020

NRF2 as an Emerging Therapeutic Target.

scientific article published on 31 January 2017

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis

scientific article published in 2022

Natural antioxidants in Alzheimer's disease

scientific article published on December 2007

Neuroprotective effects of sulforaphane after contusive spinal cord injury.

scientific article

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase

scientific article published on 20 May 2015

Nitric oxide in cell survival: a janus molecule

scientific article

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

scientific article

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

scientific article published on 24 March 2015

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

scientific article published on 14 January 2016

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

scientific article published on 30 January 2022

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

scientific article

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

scientific article published on 20 June 2013

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

scientific article published on 09 December 2020

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

scientific article published on 5 December 2014

Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes

scientific article published on 13 July 2016

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

scientific article published on 20 March 2020

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

scientific article published in November 2017

Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.

scientific article

Oxidative Stress in Cancer

scientific article published on 23 June 2020

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

scientific article

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

scientific article

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates.

scientific article

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

scientific article

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.

scientific article

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1

scientific article published on 19 June 2018

Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants.

scientific article published on May 2007

Phenolics in Aging and Neurodegenerative Disorders

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein-Protein Interaction Inhibitors with an Alternative Binding Mode

scientific article published on 12 May 2022

Phylogenetic Links in Plant Defense Systems: Lignans, Isoflavonoids, and Their Reductases

article

Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms

scientific article

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

scholarly article

Potency of extracts from selected Egyptian plants as inducers of the Nrf2-dependent chemopreventive enzyme NQO1.

scientific article published on 27 April 2016

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

scientific article

Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane

scientific article

Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state

scientific article

Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors

scientific article published on February 2009

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

scientific article published on 7 March 2007

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

scientific article published on 3 November 2005

Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes

scientific article

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

scientific article (publication date: 17 February 2004)

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

scientific article

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

scientific article published in February 2002

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety

scientific article published on 18 May 2020

Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

scientific article published on August 2008

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

scientific article

Regiochemical control of monolignol radical coupling: a new paradigm for lignin and lignan biosynthesis.

scientific article published in March 1999

Regulation of the mammalian heat shock factor 1.

scientific article

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

scientific article published on 28 August 2013

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

scientific article published on 01 May 1999

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

scientific article

Rhodiola rosea L.: from golden root to green cell factories

Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates

scientific article published on January 2004

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

scientific article published on 9 July 2016

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

scientific article published on 01 January 2006

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

scientific article published on 21 October 2016

Stereospecificity of (+)-pinoresinol and (+)-lariciresinol reductases from Forsythia intermedia.

scientific article

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

scholarly article

Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells

scientific article published on 06 October 2020

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.

scientific article published on 05 December 2013

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w ⬇️

scholarly article by Paul Meakin published in September 2014

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent.

scientific article published on April 2011

Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of it

scientific article published on 21 August 2013

Synthesis and biological evaluation of novel 2-phenylquinazoline-4-amine derivatives: identification of 6-phenyl-8H-benzo[g]quinazolino[4,3-b]quinazolin-8-one as a highly potent inducer of NAD(P)H quinone oxidoreductase 1.

scientific article

Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.

scientific article published on August 2014

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

scientific article published on 7 May 2012

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel 2-phenylquinazolin-4-amine derivatives

scientific article published on 07 April 2016

Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.

scientific article published on 14 January 2014

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

scientific article published on 4 January 2018

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

scientific article published on January 2004

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis

scientific article

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

scientific article published in January 2023

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

scientific article published on 16 March 2014

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response

scientific article published on 23 December 2012

The cytoprotective role of the Keap1-Nrf2 pathway

scientific article published on 02 March 2011

The emerging role of Nrf2 in mitochondrial function

scientific article published on 11 May 2015

The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

scientific article

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

scientific article published on 05 August 2019

The multifaceted role of Nrf2 in mitochondrial function

The role of Keap1 in cellular protective responses

scientific article

The role of Nrf2 signaling in counteracting neurodegenerative diseases

scientific article published on 11 January 2018

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics

scientific article

The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress

scientific article published on 02 December 2020

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

scientific article published on 01 April 2019

Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection.

scientific article

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

scientific article published on 8 September 2017

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

scientific article

Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis

scientific article published on March 2009

Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases.

scientific article published on January 2009

Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma

scientific article

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