List of works - Kiyosei Takasu

A practical catalytic method for preparing highly substituted cyclobutanes and cyclobutenes.

scientific article

An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short-Lived Intermediates with Planar Chirality

scientific article published on 22 July 2015

Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

scientific article published on 25 April 2019

Atropisomerism of alpha,beta-unsaturated amidines: stereoselective synthesis by catalytic cascade reaction and optical resolution

scientific article published on 01 July 2009

Auto-tandem catalysis in the synthesis of substituted quinolines from aldimines and electron-rich olefins: cascade Povarov-hydrogen-transfer reaction

scientific article published on 30 August 2008

Auto-tandem catalysis: a single catalyst activating mechanistically distinct reactions in a single reactor.

scientific article published in November 2009

Auto-tandem catalysis: facile synthesis of substituted alkylidenecyclohexanones by domino (4+2) cycloaddition–elimination reaction ⬇️

scientific article published on September 28, 2010

Catalyst-controlled torquoselectivity switch in the 4π ring-opening reaction of 2-amino-2-azetines giving β-substituted α,β-unsaturated amidines

scientific article published on 16 May 2011

Catalytic asymmetric synthesis of both enantiomers of 4‑substituted 1,4-dihydropyridines with the use of bifunctional thiourea-ammonium salts bearing different counterions.

scientific article published on 15 November 2010

CompRet: a comprehensive recommendation framework for chemical synthesis planning with algorithmic enumeration

publication published on 01 September 2020

Conformation of 1,4-dineopentyl-2,5-cis-diphenylpiperazine and its diammonium salts: remarkable change in conformation depending upon the counter anion.

scientific article published in May 2001

Conformational difference between mono- and diprotonated cis-2,5-diphenylpiperazinium salts in the solid state

scientific article published on 01 December 2000

Development of a Brønsted acid-promoted arene-ynamide cyclization toward the total syntheses of marinoquinolines A and C and aplidiopsamine A

scientific article published on 26 December 2014

Enantioselective Total Synthesis of (−)- and (+)-Petrosin ⬇️

scientific article published on October 18, 2010

Enhanced rate and selectivity by carboxylate salt as a basic cocatalyst in chiral N-heterocyclic carbene-catalyzed asymmetric acylation of secondary alcohols

scientific article published on 24 July 2013

Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization-(2 + 2) cycloaddition

scientific article published on 27 April 2012

Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL).

scientific article

Formal (3+3) cycloaddition of silyl enol ethers catalyzed by trifric imide: domino Michael addition-claisen condensation accompanied with isomerization of silyl enol ethers

scientific article published on 01 January 2011

General entry to asymmetric one-pot [N + 2 + n] cyclization for the synthesis of three- to seven-membered azacycloalkanes

scientific article published on 20 August 2012

Gold(I)-Catalyzed Polycyclizations of Polyenyne-Type Anilines Based on Hydroamination and Consecutive Hydroarylation Cascade

scientific article published on 06 October 2011

Helical Nanographenes Embedded with Contiguous Azulene Units

scientific article published on 17 July 2020

Hydroxyl group-directed organocatalytic asymmetric Michael addition of alpha,beta-unsaturated ketones with alkenylboronic acids

scientific article published on 01 June 2009

New stereoselective entry to azaspirocyclic nucleus of halichlorine and pinnaic acids by radical translocation/cyclization reaction

scientific article published on 01 August 2003

Novel intramolecular (4 + 1) and (4 + 2) annulations of halopolyenes by cascade radical reaction

scientific article published on 01 November 2000

Organocatalytic Activation of the Leaving Group in the Intramolecular Asymmetric SN 2' Reaction

scientific article published on 28 May 2015

Oxa- and Azacycle Formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene

scientific article published on 10 March 2016

Parallel synthesis of antimalarial rhodacyanine dyes by the combination of three components in one pot.

scientific article published in May 2003

Pi-delocalized beta-carbolinium cations as potential antimalarials.

scientific article published in April 2004

Prediction and Interpretable Visualization of Retrosynthetic Reactions Using Graph Convolutional Networks

scientific article published on 09 December 2019

Radical aminomethylation of imines

scientific article published on 21 August 2014

Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision

scientific article published on 22 May 2019

Rapid assembly of polycyclic substances by a multicomponent cascade (4 + 2)-(2 + 2) cycloadditions: total synthesis of the proposed structure of paesslerin A

scientific article published on 01 February 2004

Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity

scientific article published on 01 February 2002

Room-temperature, acid-catalyzed [2+2] cycloadditions: suppression of side reactions by using a flow microreactor system

scientific article published on 27 October 2011

Site-selective benzoin-type cyclization of unsymmetrical dialdoses catalyzed by N-heterocyclic carbenes for divergent cyclitol synthesis.

scientific article published on 5 April 2017

Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc

scientific article published on 26 April 2016

Synthesis and Properties of Tribenzocarbazoles via an Acid-Promoted Retro (2+2)-Cycloaddition of Azapropellanes

scientific article published on 11 June 2018

Synthesis and antimalarial efficacy of aza-fused rhodacyanines in vitro and in the P. berghei mouse model

scientific article published on July 2006

Synthesis and antimalarial property of orally active phenoxazinium salts.

scientific article published on 19 April 2007

Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists

scientific article published in June 2017

Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis.

scientific article published in June 2005

Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5-disubstituted triazole.

scientific article published on 15 November 2010

Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4π Electrocyclic Ring Opening/Alkylation Sequence

scientific article published on 24 July 2019

Synthesis of Polycyclic Spirocarbocycles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes

scientific article published on 09 September 2019

Synthesis of functionalized polycyclic aromatic compounds via a formal [2 + 2]-cycloaddition

scientific article published on 17 January 2014

Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity

scientific article published on 12 September 2006

Synthesis of π-Extended Fluoranthenes via a KHMDS-Promoted Anionic-Radical Reaction Cascade.

scientific article

Synthetic studies toward penitrem E: enantiocontrolled construction of B-E rings

scientific article published on 01 January 2015

Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides, and Echinocidins

scientific article published on 12 August 2019

Total Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction

scientific article published on 19 December 2016

Total Synthesis of (-)-Sigillin A: A Polychlorinated and Polyoxygenated Natural Product

scientific article published on 16 September 2020

Total synthesis of (+)-trans-dihydronarciclasine utilizing asymmetric conjugate addition

scientific article published on 12 November 2012

Total synthesis of (-)-kopsinine by an asymmetric one-pot [n+2+3] cyclization

scientific article published on 21 August 2012

Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp(3) -Hybridized Carbon Atoms: Kinetic Resolution of β-Amino Alcohols by p-Methoxybenzylation.

scientific article published in October 2016

[Development of boomerang-type intramolecular cascade reactions and application to natural product synthesis]

scientific article published on 01 December 2001

π-Delocalized Lipophilic Cations as New Candidates for Antimalarial, Antitrypanosomal and Antileishmanial Agents: Synthesis, Evaluation of Antiprotozoal Potency, and Insight into Their Action Mechanisms

scientific article

List of works by Kiyosei Takasu

A practical catalytic method for preparing highly substituted cyclobutanes and cyclobutenes.

An Arylative Ring Expansion Cascade of Fused Cyclobutenes via Short-Lived Intermediates with Planar Chirality

Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

Atropisomerism of alpha,beta-unsaturated amidines: stereoselective synthesis by catalytic cascade reaction and optical resolution

Auto-tandem catalysis in the synthesis of substituted quinolines from aldimines and electron-rich olefins: cascade Povarov-hydrogen-transfer reaction

Auto-tandem catalysis: a single catalyst activating mechanistically distinct reactions in a single reactor.

Auto-tandem catalysis: facile synthesis of substituted alkylidenecyclohexanones by domino (4+2) cycloaddition–elimination reaction ⬇️

Catalyst-controlled torquoselectivity switch in the 4π ring-opening reaction of 2-amino-2-azetines giving β-substituted α,β-unsaturated amidines

Catalytic asymmetric synthesis of both enantiomers of 4‑substituted 1,4-dihydropyridines with the use of bifunctional thiourea-ammonium salts bearing different counterions.

CompRet: a comprehensive recommendation framework for chemical synthesis planning with algorithmic enumeration

Conformation of 1,4-dineopentyl-2,5-cis-diphenylpiperazine and its diammonium salts: remarkable change in conformation depending upon the counter anion.

Conformational difference between mono- and diprotonated cis-2,5-diphenylpiperazinium salts in the solid state

Development of a Brønsted acid-promoted arene-ynamide cyclization toward the total syntheses of marinoquinolines A and C and aplidiopsamine A

Enantioselective Total Synthesis of (−)- and (+)-Petrosin ⬇️

Enhanced rate and selectivity by carboxylate salt as a basic cocatalyst in chiral N-heterocyclic carbene-catalyzed asymmetric acylation of secondary alcohols

Facile isomerization of silyl enol ethers catalyzed by triflic imide and its application to one-pot isomerization-(2 + 2) cycloaddition

Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL).

Formal (3+3) cycloaddition of silyl enol ethers catalyzed by trifric imide: domino Michael addition-claisen condensation accompanied with isomerization of silyl enol ethers

General entry to asymmetric one-pot [N + 2 + n] cyclization for the synthesis of three- to seven-membered azacycloalkanes

Gold(I)-Catalyzed Polycyclizations of Polyenyne-Type Anilines Based on Hydroamination and Consecutive Hydroarylation Cascade

Helical Nanographenes Embedded with Contiguous Azulene Units

Hydroxyl group-directed organocatalytic asymmetric Michael addition of alpha,beta-unsaturated ketones with alkenylboronic acids

New stereoselective entry to azaspirocyclic nucleus of halichlorine and pinnaic acids by radical translocation/cyclization reaction

Novel intramolecular (4 + 1) and (4 + 2) annulations of halopolyenes by cascade radical reaction

Organocatalytic Activation of the Leaving Group in the Intramolecular Asymmetric SN 2' Reaction

Oxa- and Azacycle Formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene

Parallel synthesis of antimalarial rhodacyanine dyes by the combination of three components in one pot.

Pi-delocalized beta-carbolinium cations as potential antimalarials.

Prediction and Interpretable Visualization of Retrosynthetic Reactions Using Graph Convolutional Networks

Radical aminomethylation of imines

Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision

Rapid assembly of polycyclic substances by a multicomponent cascade (4 + 2)-(2 + 2) cycloadditions: total synthesis of the proposed structure of paesslerin A

Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity

Room-temperature, acid-catalyzed [2+2] cycloadditions: suppression of side reactions by using a flow microreactor system

Site-selective benzoin-type cyclization of unsymmetrical dialdoses catalyzed by N-heterocyclic carbenes for divergent cyclitol synthesis.

Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc

Synthesis and Properties of Tribenzocarbazoles via an Acid-Promoted Retro (2+2)-Cycloaddition of Azapropellanes

Synthesis and antimalarial efficacy of aza-fused rhodacyanines in vitro and in the P. berghei mouse model

Synthesis and antimalarial property of orally active phenoxazinium salts.

Synthesis and biological evaluation of steroidal derivatives bearing a small ring as vitamin D receptor agonists

Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis.

Synthesis and properties of chiral thioureas bearing an additional function at a remote position tethered by a 1,5-disubstituted triazole.

Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4π Electrocyclic Ring Opening/Alkylation Sequence

Synthesis of Polycyclic Spirocarbocycles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes

Synthesis of functionalized polycyclic aromatic compounds via a formal [2 + 2]-cycloaddition

Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity

Synthesis of π-Extended Fluoranthenes via a KHMDS-Promoted Anionic-Radical Reaction Cascade.

Synthetic studies toward penitrem E: enantiocontrolled construction of B-E rings

Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides, and Echinocidins

Total Synthesis of (-)-Histrionicotoxin through a Stereoselective Radical Translocation-Cyclization Reaction

Total Synthesis of (-)-Sigillin A: A Polychlorinated and Polyoxygenated Natural Product

Total synthesis of (+)-trans-dihydronarciclasine utilizing asymmetric conjugate addition

Total synthesis of (-)-kopsinine by an asymmetric one-pot [n+2+3] cyclization

Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp(3) -Hybridized Carbon Atoms: Kinetic Resolution of β-Amino Alcohols by p-Methoxybenzylation.

[Development of boomerang-type intramolecular cascade reactions and application to natural product synthesis]

π-Delocalized Lipophilic Cations as New Candidates for Antimalarial, Antitrypanosomal and Antileishmanial Agents: Synthesis, Evaluation of Antiprotozoal Potency, and Insight into Their Action Mechanisms