List of works - Bryan T Mott

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

scientific article published on 6 February 2014

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

scientific article

An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities

scientific article

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

scientific article published on 12 January 2016

Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.

scientific article

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure–activity study ⬇️

scientific article published on April 22, 2013

Biochemical assays for the discovery of TDP1 inhibitors

scientific article

Comparison of bioluminescent kinase assays using substrate depletion and product formation

scientific article

Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors

scientific article

Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity

scientific article

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

scientific article published on 3 February 2016

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

scientific article

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

scientific article

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

scientific article

High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase

scientific article

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

scientific article

In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility

scientific article published on 02 December 2013

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine

scientific article published on 15 December 2011

Personalized medicine: changing the paradigm of drug development.

scientific article published on January 2012

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

scientific article

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

scientific article

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

scientific article

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

scientific journal article

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds

scientific article published on 13 July 2016

Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs

scientific article

The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether

scientific article published on 30 January 2014

Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.

scientific article published on 17 June 2013

mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening.

scientific article

List of works by Bryan T Mott

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure–activity study ⬇️

Biochemical assays for the discovery of TDP1 inhibitors

Comparison of bioluminescent kinase assays using substrate depletion and product formation

Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors

Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations

High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine

Personalized medicine: changing the paradigm of drug development.

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds

Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs

The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether

Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.

mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening.