List of works - Shailesh N Mistry

27th Annual GP2A Medicinal Chemistry Conference

scientific article published on 06 December 2019

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

scientific article published in December 2015

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

scientific article published on 23 April 2018

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors

scientific article published on 24 April 2018

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

scientific article

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

scientific article published on 10 August 2015

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

scientific article published on 17 August 2016

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

scientific article

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

scientific article published on 17 January 2014

Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior

scientific article published on 14 September 2016

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

scientific article

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

scientific article published on 20 February 2015

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

scientific article published on 23 October 2019

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.

scientific article published on 24 June 2015

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

scientific article published on 16 September 2011

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

scientific article published on 10 May 2013

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

scientific article published on 17 June 2013

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

scientific article

List of works by Shailesh N Mistry

27th Annual GP2A Medicinal Chemistry Conference

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

Positive Allosteric Modulation of the Muscarinic M1 Receptor Improves Efficacy of Antipsychotics in Mouse Glutamatergic Deficit Models of Behavior

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor

Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.

Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors