List of works by Malcolm Molyneux

A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria

scientific article published on 07 June 2013

A medical career in Malawi - personal reflections.

scientific article published on September 2016

A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells

scientific article

A prospective study of bloodstream infections as cause of fever in Malawi: clinical predictors and implications for management

scientific article published on August 2004

A trial of a 7-valent pneumococcal conjugate vaccine in HIV-infected adults

scientific article published in March 2010

A trial of a 7-valent pneumococcal conjugate vaccine in HIV-infected adults.

scientific article published in September 2016

Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study

scientific article published on 20 November 2011

Affordable pediatric CD4 counting by flow cytometry in Malawi

scientific article published on January 2008

Age- and sex-related changes in hematological parameters in healthy Malawians

scientific article published on 28 August 2017

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*

scientific article published on March 2012

Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the QuEERPAM study

scientific article

Antibodies that induce phagocytosis of malaria infected erythrocytes: effect of HIV infection and correlation with clinical outcomes

scientific article

Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets

scientific article published on 21 January 2004

Are Plasmodium falciparum parasites present in peripheral blood genetically the same as those sequestered in the tissues?

scientific article published in May 2006

Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children

scientific article

Association of the GNAS locus with severe malaria

scientific article published on 26 October 2008

Author Correction for Hochman et al., Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

scientific article published on 2 February 2016

Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome.

scientific article published on 2 February 2007

Bacterial meningitis in Malawian adults, adolescents, and children during the era of antiretroviral scale-up and Haemophilus influenzae type b vaccination, 2000-2012.

scientific article published on 04 February 2014

Bednets and malaria in Africa

scientific article published on September 2016

Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study ⬇️

scientific article published on November 4, 2010

Blood culture collection technique and pneumococcal surveillance in Malawi during the four year period 2003-2006: an observational study

scientific article published on 14 October 2008

Blood-brain barrier function in cerebral malaria in Malawian children

scientific article published in March 2001

Brain swelling and death in children with cerebral malaria

scientific article published on March 2015

CCR5 haplotypes and mother-to-child HIV transmission in Malawi

scientific article

CD16+ monocyte subset preferentially harbors HIV-1 and is expanded in pregnant Malawian women with Plasmodium falciparum malaria and HIV-1 infection

scientific article published on 16 May 2007

Cerebral malaria

scientific article published in The Lancet

Cerebral malaria in children: using the retina to study the brain

scientific article published on 26 February 2014

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

scientific article published on 09 January 2017

Chemokine responses are increased in HIV-infected Malawian children with invasive pneumococcal disease

scientific article published on April 2007

Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma

scientific article published in June 2004

Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction

scientific article

Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment

scientific article

Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria

scientific article

Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi

scientific article

Competitive endothelial adhesion between Plasmodium falciparum isolates under physiological flow conditions

scientific article published on 21 September 2009

Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria

scientific article published in February 2013

Control lymphocyte subsets: can one country's values serve for another's?

scientific article

Correction: Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations.

scientific article published on 27 June 2013

Correlation of hemorrhage, axonal damage, and blood-tissue barrier disruption in brain and retina of Malawian children with fatal cerebral malaria

scientific article

Decreasing burden of malaria in pregnancy in Malawian women and its relationship to use of intermittent preventive therapy or bed nets

scientific article

Decreasing malaria prevalence and its potential consequences for immunity in pregnant women

scientific article published on 5 May 2014

Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi

scientific article

Detection and characterization of human caliciviruses in hospitalized children with acute gastroenteritis in Blantyre, Malawi

scientific article published in December 2005

Detection of raised intracranial pressure by ultrasound measurement of optic nerve sheath diameter in African children

scientific article published on 13 October 2008

Developing national treatment policy for falciparum malaria in Africa: Malawi experience

scientific article published on 13 March 2009

Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study

scientific article published on 17 July 2007

Differential PfEMP1 expression is associated with cerebral malaria pathology ⬇️

scientific article published on 4 December 2014

Differential antibody responses to Plasmodium falciparum merozoite proteins in Malawian children with severe malaria

scientific article published in March 2008

Differential var gene expression in the organs of patients dying of falciparum malaria

scientific article

Differentiating the pathologies of cerebral malaria by postmortem parasite counts

scientific article published on 25 January 2004

Does This Patient Have Malaria? ⬇️

scientific article published on November 5, 2010

Domestic smoke exposure is associated with alveolar macrophage particulate load

scientific article published on March 2009

Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study

scientific article

Effect of transmission setting and mixed species infections on clinical measures of malaria in Malawi

scientific article

Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi

scientific article

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria

scientific article

Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study

scientific article

Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype

scientific article published on 9 November 2009

Epidemics of invasive Salmonella enterica serovar enteritidis and S. enterica Serovar typhimurium infection associated with multidrug resistance among adults and children in Malawi

scientific article published on April 2008

Epidemiology of rotavirus infection in children in Blantyre, Malawi, 1997-2007.

scientific article

Estimating physical splenic filtration of Plasmodium falciparum-infected red blood cells in malaria patients

scientific article published on 4 September 2012

Etiology of suspected pneumonia in adults admitted to a high-dependency unit in Blantyre, Malawi

scientific article

Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients

scientific article published on 26 February 2016

Evoked potentials in pediatric cerebral malaria

scientific article published on November 2011

Expression of merozoite surface protein markers by Plasmodium falciparum-infected erythrocytes in peripheral blood and tissues of children with fatal malaria

scientific article published on 21 November 2006

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

scientific article

Finger-prick blood samples can be used interchangeably with venous samples for CD4 cell counting indicating their potential for use in CD4 rapid tests

scientific article

Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis

scientific article

Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria

scientific article published on 31 May 2006

Genome-wide and fine-resolution association analysis of malaria in West Africa

scientific article

Genotypic homogeneity of multidrug resistant S. Typhimurium infecting distinct adult and childhood susceptibility groups in Blantyre, Malawi

scientific article published on 27 July 2012

Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial

scientific article published on 18 February 2011

Grading fluorescein angiograms in malarial retinopathy

scientific article

HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children

scientific article published on 13 June 2016

HIV infected adults do not have an excess of colonising bacteria in their large airways

scientific article

HIV infection compounds the lymphopenia associated with cerebral malaria in Malawian children

article

HIV-1 infection and antibodies to Plasmodium falciparum in adults

scientific article published on 3 May 2014

HIV-1 infection is associated with altered innate pulmonary immunity

scientific article published on 14 September 2005

Haplotypic analysis of the TNF locus by association efficiency and entropy

scientific article

High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease

scientific article

Host response to malaria during pregnancy: placental monocyte recruitment is associated with elevated beta chemokine expression

scientific article published in March 2003

Human cerebral malaria and Plasmodium falciparum genotypes in Malawi

scientific article published on 7 February 2012

Identification of malaria retinopathy improves the specificity of the clinical diagnosis of cerebral malaria: findings from a prospective cohort study

scientific article

Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection

scientific article published in July 2002

Impact of human immunodeficiency virus infection in pregnant women on variant-specific immunity to malaria

scientific article published on 16 January 2008

Impact of human immunodeficiency virus infection on the etiology and outcome of severe pneumonia in Malawian children

scientific article published in January 2011

Impairment of humoral immunity to Plasmodium falciparum malaria in pregnancy by HIV infection

scientific article published in June 2004

Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidal Salmonella by blood cells in Africans

scientific article

Imputation-based meta-analysis of severe malaria in three African populations

scientific article

In vitro antimalarial susceptibility profile and prcrt/pfmdr-1 genotypes of Plasmodium falciparum field isolates from Malawi

scientific article published on June 2007

Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis

scientific article

Inhaled delivery of 23-valent pneumococcal polysaccharide vaccine does not result in enhanced pulmonary mucosal immunoglobulin responses

scientific article published on 15 August 2008

Invasive non-typhoid salmonellae establish systemic intracellular infection in HIV-infected adults: an emerging disease pathogenesis

scientific article published on April 2010

Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations

scientific article

Leukocyte counts and lymphocyte subsets in relation to pregnancy and HIV infection in Malawian women

scientific article published on 6 April 2017

Likely health outcomes for untreated acute febrile illness in the tropics in decision and economic models; a Delphi survey

scientific article

Liver pathology in Malawian children with fatal encephalopathy

scientific article

Long term outcome of severe anaemia in Malawian children

scientific article

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

scientific article published on 05 June 2013

Low level genotypic chloroquine resistance near Malawi's northern border with Tanzania

scientific article published on 14 July 2009

Lymphocyte subsets in healthy Malawians: implications for immunologic assessment of HIV infection in Africa

scientific article

Malaria and vitamin A deficiency in African children: a vicious circle?

scientific article published on 17 June 2009

Malaria during pregnancy and foetal haematological status in Blantyre, Malawi

scientific article

Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria

scientific article published in June 2010

Malarial retinopathy: a newly established diagnostic sign in severe malaria

scientific article

Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi.

scientific article

Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi

scientific article

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi

scientific article published on 26 August 2009

Modelling the Contributions of Malaria, HIV, Malnutrition and Rainfall to the Decline in Paediatric Invasive Non-typhoidal Salmonella Disease in Malawi

scientific article published on 31 July 2015

Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria

scientific article published on 17 January 2002

Molecular surveillance for drug-resistant Plasmodiumfalciparum malaria in Malawi

scientific article published on 24 April 2007

Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi

scientific article

Mycobacterium tuberculosis resides in nonacidified vacuoles in endocytically competent alveolar macrophages from patients with tuberculosis and HIV infection

scientific article published in April 2004

Neuroimaging findings in children with retinopathy-confirmed cerebral malaria

scientific article published on 03 April 2009

Neurologic outcomes in retinopathy-negative cerebral malaria survivors

scientific article

Non-typhoidal salmonella (NTS) bacteraemia in Malawian adults: a severe, recrudescent, HIV-associated illness.

scientific article published on June 2003

Non-typhoidal salmonella bacteraemia among HIV-infected Malawian adults: high mortality and frequent recrudescence

scientific article published in August 2002

Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children

scientific article

Nucleotide diversity of the TNF gene region in an African village

scientific article

PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia

scientific article

Parasites bearing a single copy of the multi-drug resistance gene (pfmdr-1) with wild-type SNPs predominate amongst Plasmodium falciparum isolates from Malawi

scientific article

Pathology-Based Research in Africa

scientific article published in March 2018

Pathophysiological mechanisms of severe anaemia in Malawian children

scientific article

Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi

scientific article (publication date: 2011)

Perfusion abnormalities in children with cerebral malaria and malarial retinopathy

scientific article published on January 2009

Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children

scientific article published on 17 September 2013

Placental hypoxia during placental malaria

scientific article

Placental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity

scientific article

Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes

scientific article published in January 2003

Placental tumor necrosis factor alpha but not gamma interferon is associated with placental malaria and low birth weight in Malawian women

scientific article

Plasma concentrations of parasite histidine-rich protein 2 distinguish between retinopathy-positive and retinopathy-negative cerebral malaria in Malawian children

scientific article

Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants

scientific article published in March 2002

Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria

scientific article published on 24 January 2003

Pneumococcal conjugate vaccine is immunogenic in lung fluid of HIV-infected and immunocompetent adults

scientific article published on 04 June 2007

Pneumococcal disease in HIV-infected Malawian adults: acute mortality and long-term survival

scientific article published on July 2002

Poor potential coverage for 7-valent pneumococcal conjugate vaccine, Malawi

scientific article published on June 2003

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

scientific article published in November 2006

Positive selection of a CD36 nonsense variant in sub-saharan Africa, but no association with severe malaria phenotypes

scientific article published on 29 April 2009

Practical issues in relation to clinical trials in children in low-income countries: experience from the front line

article

Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study

scientific article published on 7 December 2017

Prevalence and spectrum of illness among hospitalized adults with malaria in Blantyre, Malawi

scientific article

Prevalence of raised intracranial pressure in cerebral malaria detected by optic nerve sheath ultrasound

scientific article

Primary macrophages from HIV-infected adults show dysregulated cytokine responses to Salmonella, but normal internalization and killing

scientific article

Prognostic significance and course of retinopathy in children with severe malaria

scientific article

Pulmonary pathology in pediatric cerebral malaria

scientific article published on 27 September 2013

Quantitative Assessment of Multiorgan Sequestration of Parasites in Fatal Pediatric Cerebral Malaria

scientific article

Rabies encephalitis in malaria-endemic area, Malawi, Africa

scientific article published on January 2007

Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

scientific article published on 6 November 2009

Reaching Millennium Development Goal 4.

scientific article

Redefining cerebral malaria by including malaria retinopathy

scientific article published in March 2011

Reduced interleukin-8 response to Streptococcus pneumoniae by alveolar macrophages from adults with HIV/AIDS.

scientific article published in July 2005

Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malaria

scientific article published on 07 January 2009

Reply: Retinopathy, histidine-rich protein-2 and perfusion pressure in cerebral malaria

scientific article published on 11 June 2014

Resistance to malaria through structural variation of red blood cell invasion receptors

scientific article published on 18 May 2017

Resistance to malaria through structural variation of red blood cell invasion receptors

scholarly article published 26 October 2016

Retinal pathology of pediatric cerebral malaria in Malawi

scientific article

Risk factors and mechanisms of preterm delivery in Malawi

scientific article

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4. ⬇️

scientific article

Sampling of supraorbital brain tissue after death: improving on the clinical diagnosis of cerebral malaria

scientific article published on 28 January 2005

Schistosomiasis does not contribute to death or recurrence of nontyphoid Salmonella bacteremia in human immunodeficiency virus-infected Malawian adults

scientific article published on 19 November 2003

Severe anemia in Malawian children

scientific article

Severe anemia in Malawian children

scientific article published in September 2016

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

scientific article published on 18 January 2018

Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre, Malawi, 2000-2004.

scientific article published on September 2008

Soluble CD163, a product of monocyte/macrophage activation, is inversely associated with haemoglobin levels in placental malaria

scientific article

Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi

scientific article

Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo

scientific article

Supraorbital postmortem brain sampling for definitive quantitative confirmation of cerebral sequestration of Plasmodium falciparum parasites

scientific article

Surveillance Programme of IN-patients and Epidemiology (SPINE): implementation of an electronic data collection tool within a large hospital in Malawi

scientific article

Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective study

scientific article published on 02 February 2004

T-Regulatory Cells and Inflammatory and Inhibitory Cytokines in Malawian Children Residing in an Area of High and an Area of Low Malaria Transmission During Acute Uncomplicated Malaria and in Convalescence

scientific article published on 7 January 2015

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression

scientific article published on 13 March 2009

Ten years of surveillance for invasive Streptococcus pneumoniae during the era of antiretroviral scale-up and cotrimoxazole prophylaxis in Malawi ⬇️

scientific article published on 15 March 2011

The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1.

scientific article published on 19 January 2011

The Millennium Villages project

scientific article published on 08 May 2012

The alveolar microenvironment of patients infected with human immunodeficiency virus does not modify alveolar macrophage interactions with Streptococcus pneumoniae

scientific article published on 10 April 2013

The diagnostic and prognostic accuracy of five markers of serious bacterial infection in Malawian children with signs of severe infection

scientific article

The distribution and intensity of parasite sequestration in comatose Malawian children

scientific article

The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women

scientific article published in April 2004

The effect of quinine on the electroretinograms of children with pediatric cerebral malaria

scientific article published on 2 April 2003

The effects of malaria and intermittent preventive treatment during pregnancy on fetal anemia in Malawi

scientific article published on 5 July 2012

The impact of routine infant immunization with Haemophilus influenzae type b conjugate vaccine in Malawi, a country with high human immunodeficiency virus prevalence

scientific article

The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children

scientific article

The neuropathology of fatal cerebral malaria in malawian children

scientific article

The pathogenesis of pediatric cerebral malaria: eye exams, autopsies, and neuroimaging

scientific article

The pattern of bacteraemia in children with severe malaria

scientific article published on April 2002

The platelet count in cerebral malaria, is it useful to the clinician?

scientific article published on July 2010

The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children

scientific article

The systemic pathology of cerebral malaria in African children

scientific article

Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children

scientific article

Treatment of childhood Plasmodium falciparum malaria: current challenges

scientific article published on February 2007

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations

scientific article published on February 2009

Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria

scientific article

Using malarial retinopathy to improve the classification of children with cerebral malaria

scientific article published on 28 August 2008

Viral CNS infections in children from a malaria-endemic area of Malawi: a prospective cohort study

scientific article

What can we learn from the retina in severe malaria?

scientific article published in January 2010

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