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List of works by Philipp Kaldis

A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.

scientific article

A novel function for CDK2 activity at meiotic crossover sites

scientific article published on 19 October 2020

Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p

scientific article

Activating phosphorylation of the Saccharomyces cerevisiae cyclin-dependent kinase, cdc28p, precedes cyclin binding

scientific article

Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase

scientific article

Analysis of CAK activities from human cells

scientific article published on 01 July 2000

Another piece of the p27Kip1 puzzle

scientific article

Biochemical characterization of Cdk2-Speedy/Ringo A2.

scientific article

CAK-independent activation of CDK6 by a viral cyclin

scientific article

CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion

scientific article

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays

scientific article published in September 2017

CDK2 is dispensable for adult hippocampal neurogenesis

scientific article published on 14 September 2007

CDK2 kinase activity is a regulator of male germ cell fate

scientific article published on 06 November 2019

CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I

scientific article published on 26 July 2019

Cascading proton transfers are a hallmark of the catalytic mechanism of SAM-dependent methyltransferases

scientific article published on 30 April 2020

Cdk2 and Cdk4 cooperatively control the expression of Cdc2

scientific article

Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.

scientific article

Cdk2 as a master of S phase entry: fact or fake?

scientific article published on January 2004

Cdk2 catalytic activity is essential for meiotic cell division in vivo

scientific article published on July 2016

Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone

scientific article

Cdk2 knockout mice are viable

scientific article (publication date: 14 October 2003)

Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo.

scientific article published on 08 September 2009

Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.

scientific article

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

scientific article

Cell Division, a new open access online forum for and from the cell cycle community

scientific article

Cell biology. Enforcing the Greatwall in mitosis

scientific article published on 01 December 2010

Cell cycle regulation in NAFLD: when imbalanced metabolism limits cell division

scientific article published on 22 June 2020

Cell cycle sibling rivalry: Cdc2 vs. Cdk2

scientific article

Cell cycle transitions and Cdk inhibition in melanoma therapy: Cyclin' through the options ⬇️

scientific article published on May 1, 2011

Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12.

scientific article published on September 2004

Cell size control - a mechanism for maintaining fitness and function.

scientific article published on 28 July 2017

Cell-specific responses to loss of cyclin-dependent kinases.

scientific article published on 5 February 2007

Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation

scientific article published on 01 May 2006

Correction: Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

scientific article published on 01 February 2020

Cyclin A2 regulates erythrocyte morphology and numbers

scientific article

Cyclin E1 regulates hematopoietic stem cell quiescence

scientific article published on 28 October 2013

Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy

scientific article published on 14 October 2020

Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis.

scientific article published on 5 June 2017

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.

scientific article published on 21 February 2012

Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury

scientific article published on 18 July 2008

Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2

scientific article

Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases

scientific article

Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms

scientific article (publication date: 3 November 2000)

Discovery of a chemical probe for PRDM9

scientific article published on 17 December 2019

Diverse roles for CDK-associated activity during spermatogenesis

scientific article published on 20 October 2019

Down-regulation of Myc is essential for terminal erythroid maturation

scientific article

Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis.

scientific article published on 8 January 2018

Emi2 Is Essential for Mouse Spermatogenesis.

scientific article published in July 2017

Established and novel Cdk/cyclin complexes regulating the cell cycle and development.

scientific article published on January 2011

Evolution of the Cdk-activator Speedy/RINGO in vertebrates

scientific article

Expression of active octameric chicken cardiac mitochondrial creatine kinase in Escherichia coli.

scientific article published on December 1992

Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death.

scientific article published on 16 March 2018

Genetic mouse models to investigate cell cycle regulation.

scientific article published on 6 May 2009

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

scientific article published on 11 September 2008

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

scientific article published on 5 January 2012

Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress

scientific article

Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities ⬇️

scientific article published on September 1, 1998

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice

scientific article

Identification of transcriptional and metabolic programs related to mammalian cell size

scientific article published on 06 March 2014

Identification of two distinctly localized mitochondrial creatine kinase isoenzymes in spermatozoa.

scientific article published on August 1996

Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase

scientific article

Impairing Cohesin Smc1/3 Head Engagement Compensates for the Lack of Eco1 Function.

scientific article published on 27 September 2016

In vitro complex formation between the octamer of mitochondrial creatine kinase and porin

scientific article

Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan.

scientific article published on 21 October 2016

Kinase-independent function of cyclin E

scientific article published on 01 January 2007

Kinetic analysis of the cyclin-dependent kinase-activating kinase (Cak1p) from budding yeast

scientific article published on 01 October 2000

Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype

scientific article published on 13 November 2019

Localization and regulation of the cdk-activating kinase (Cak1p) from budding yeast

scientific article

Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells.

scientific article

Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis

scientific article

Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes

scientific article

Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone

scientific article published in Journal of Biological Chemistry

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

scientific article published on 04 November 2020

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

scientific article

Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter

scientific article published on 09 November 2004

MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice

scientific article published on 07 February 2017

MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.

scientific article

Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.

scientific article

Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

scientific journal article

MetaboKit: a comprehensive data extraction tool for untargeted metabolomics

scientific article published on 10 June 2020

Metabolic Remodeling during Liver Regeneration

scientific article published on 18 October 2018

Modulation of Protein-Interaction States through the Cell Cycle.

scientific article published on 21 April 2018

Molecular basis of the reaction mechanism of the methyltransferase HENMT1

scientific article published in 2024

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

scientific article published on 14 July 2020

PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes.

scientific article published in November 2006

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality

scientific article published on 06 September 2018

Quo Vadis Cell Growth and Division?

scientific article published on 30 August 2016

Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition.

scholarly article

Regulation of CDKs by phosphorylation.

scientific article published in January 1998

Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development.

scientific article

Remodelling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

scientific article published on 21 December 2020

Role of cyclin-dependent kinase 2 in the progression of mouse juvenile cystic kidney disease

scientific article published on 08 January 2020

Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint

scientific article

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation

scientific article published on 28 December 2016

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

scientific article

The Cdk-activating kinase (CAK) from budding yeast.

scientific article

The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations.

scientific article published on 13 January 2014

The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

scientific article published on 25 September 2020

The Indispensable Role of Cyclin-Dependent Kinase 1 in Skeletal Development.

scientific article published on 10 February 2016

The N-terminal peptide of the Kaposi's sarcoma-associated herpesvirus (KSHV)-cyclin determines substrate specificity

scientific article

The Speedy A, Cdk2, p27 triangle

scientific article published on 13 January 2016

The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)

scientific article published on 25 May 2022

The cdk-activating kinase (CAK): from yeast to mammals.

scientific article

The effects of changing the site of activating phosphorylation in CDK2 from threonine to serine

scientific article published on 01 October 2000

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

scientific article

Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.

scientific article

Wnt signaling in mitosis

scientific article

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.

scientific article published on 8 January 2014

p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation

scientific article

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

scientific article

p27 is regulated independently of Skp2 in the absence of Cdk2.

scientific article

p57(Kip2) regulates T-cell development and lymphoma.

scientific article

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