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List of works by Osamu Inanami

2-Chloro-2'-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4.

scientific article

3-Methyl pyruvate enhances radiosensitivity through increasing mitochondria-derived reactive oxygen species in tumor cell lines.

scientific article published on January 2014

8-Aminoadenosine enhances radiation-induced cell death in human lung carcinoma A549 cells.

scientific article

A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg.

scientific article published on 23 August 2017

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

scientific article

A novel anticancer ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells.

scientific article

A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression.

scientific article

Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.

scientific article published on 8 December 2014

Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.

scientific article published in December 1998

Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304.

scientific article published in April 1998

Analysis of the mechanism of radiation-induced upregulation of mitochondrial abundance in mouse fibroblasts

scientific article published on 14 December 2016

Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping.

scientific article

Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.

scientific article published on 23 February 2018

Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells.

scientific article published on February 1999

Bone marrow transplantation in a Holstein heifer with bovine leucocyte adhesion deficiency

scientific article published in July 1998

Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616.

scientific article published on 4 December 2017

Canine neutrophil dysfunction caused by downregulation of beta2-integrin expression without mutation.

scientific article

Characterization of JNK-like protein derived from a mosquito cell line, C6/36.

scientific article published on February 2003

Costimulatory effects of complement receptor type 3 and Fc receptor for IgG (FcgammaR) on superoxide production and signal transduction in bovine neutrophils.

scientific article published in October 2007

Different radiosensitive megakaryocytic progenitor cells exist in steady-state human peripheral blood

scientific article published on 01 July 2005

Downregulation of the DNA repair enzyme apurinic/apyrimidinic endonuclease 1 stimulates transforming growth factor-β1 production and promotes actin rearrangement.

scientific article

Dual inhibition of protein phosphatase-1/2A and calpain rescues nerve growth factor-differentiated PC12 cells from oxygen-glucose deprivation-induced cell death.

scientific article published in February 2006

ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.

scientific article published on 7 September 2013

ESR and spin-trapping study of free radicals in gamma-irradiated solid lysozyme

scientific article published on 01 January 1988

Effects of amifostine on the proliferation and differentiation of megakaryocytic progenitor cells

scientific article published in February 2002

Effects of antioxidants on X-ray- or hyperthermia-induced apoptosis in human lymphoma U937 cells.

scientific article

Effects of ceramide inhibition on radiation-induced apoptosis in human leukemia MOLT-4 cells

scientific article published on 01 March 2006

Effects of intracellular calcium chelator BAPTA-AM on radiation-induced apoptosis regulated by activation of SAPK/JNK and caspase-3 in MOLT-4 cells

scientific article published on 01 September 1999

Effects of the combination of thrombopoietin with cytokines on the survival of X-irradiated CD34(+) megakaryocytic progenitor cells from normal human peripheral blood

scientific article published on 01 August 2002

Elevation of intracellular calcium ions is essential for the H2O2-induced activation of SAPK/JNK but not for that of p38 and ERK in Chinese hamster V79 cells.

scientific article published on January 1999

Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X rays and death receptor agonists.

scientific article

Enhancement of cell death by TNF alpha-related apoptosis-inducing ligand (TRAIL) in human lung carcinoma A549 cells exposed to x rays under hypoxia

scientific article

Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR.

scientific article published on 5 April 2018

Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro

scientific article published on February 2016

FMLP-induced formation of F-actin in HL60 cells is dependent on PI3-K but not on intracellular Ca2+, PKC, ERK or p38 MAPK

scientific article published on 01 December 2000

Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene.

scientific article

Feasibility of in vivo three-dimensional T 2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging.

scientific article published on 6 January 2017

Hypoxia and etanidazole alter radiation-induced apoptosis in HL60 cells but not in MOLT-4 cells.

scientific article

Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique

scientific article published on 26 September 2006

In vivo extracellular pH mapping of tumors using electron paramagnetic resonance

scientific article published on 08 November 2018

In vivo tumour extracellular pH monitoring using electron paramagnetic resonance: the effect of X-ray irradiation

scientific article

Induction of apoptosis through the activation of SAPK/JNK followed by the expression of death receptor Fas in X-irradiated cells.

scientific article published on September 2003

Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway

scientific article (publication date: 31 August 2001)

Inhibition of cell proliferation by SARS-CoV infection in Vero E6 cells

scientific article published in March 2006

Inhibition of collagen-induced platelet aggregation in Japanese black cattle with inherited platelet disorder, Chediak-Higashi syndrome

scientific article published on 01 July 1996

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation.

scientific article

Instability of familial spongiform encephalopathy-related prion mutants.

scientific article published on 4 December 2007

Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils.

scientific article published in April 2006

Ionizing radiation induces mitochondrial reactive oxygen species production accompanied by upregulation of mitochondrial electron transport chain function and mitochondrial content under control of the cell cycle checkpoint.

scientific article published on 8 May 2012

LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence

scientific article published on 27 August 2021

Lipid peroxide levels and superoxide-scavenging abilities of Sera obtained from hotbred (Thoroughbred) horses

scientific article published on 01 February 1996

Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine (Cladribine) in leukemia cell lines.

scientific article published on 26 May 2006

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells.

scientific article published on 13 January 2017

MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis.

scientific article published on 24 May 2017

Magnetic resonance imaging of alveolar echinococcosis experimentally induced in the rat lung

scientific article published on 01 January 2006

Mechanism of photosensitization by pheophorbide alpha studied by photohemolysis of erythrocytes and electron spin resonance spectroscopy

scientific article published on 01 January 1989

Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets

scientific article

NADPH oxidase 4 mediates ROS production in radiation-induced senescent cells and promotes migration of inflammatory cells.

scientific article published on 12 December 2017

Neuron is the primary target of Ca2+ paradox-type insult-induced cell injury in neuron/astrocyte co-cultures.

scientific article published on 18 October 2007

Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins

scientific article published on 01 March 2000

Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats ⬇️

scientific article published on May 25, 1992

Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis

scientific article published on 27 September 2019

Nucleosides and nucleotides. 176. 2'-Deoxy-2'-hydroxylaminocytidine: a new antitumor nucleoside that inhibits DNA synthesis although it has a ribonucleoside structure

scientific article published on 01 July 1998

OH-induced free radicals in 3'-UMP and poly(U): spin-trapping and radical chromatography

scientific article published on 01 October 1987

OH-induced free radicals in purine nucleosides and their homopolymers: e.s.r. and spin-trapping with 2-methyl-2-nitrosopropane

scientific article published on 01 May 1986

Oral administration of (-)catechin protects against ischemia-reperfusion-induced neuronal death in the gerbil.

scientific article published in October 1998

Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction

scientific article published on 27 May 2011

Phosphoinositide 3-kinase regulates the phosphorylation of NADPH oxidase component p47(phox) by controlling cPKC/PKCdelta but not Akt.

scientific article published in April 2004

Post-irradiation hypoxic incubation of X-irradiated MOLT-4 cells reduces apoptotic cell death by changing the intracellular redox state and modulating SAPK/JNK pathways.

scientific article

Preclinical study on hypoxic radiosensitizing effects of glycididazole in comparison with those of doranidazole in vitro and in vivo.

scientific article published on 23 November 2017

Proinsulin C-peptide abrogates type-1 diabetes-induced increase of renal endothelial nitric oxide synthase in rats.

scientific article

Protective effects of thrombopoietin and stem cell factor on X-irradiated CD34+ megakaryocytic progenitor cells from human placental and umbilical cord blood.

scientific article

Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II.

scientific article

Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation

scientific article published in October 2017

Radiation sensitivity of megakaryocyte colony-forming cells in human placental and umbilical cord blood

scientific article published on 01 February 2000

Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model.

scientific article published on 2 July 2013

Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.

scientific article published on 14 February 2014

Reactive oxygen species mediate shear stress-induced fluid-phase endocytosis in vascular endothelial cells.

scientific article published in February 2006

Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.

scientific article

Reduction of concanavalin A-induced expression of interferon-gamma by bovine lactoferrin in feline peripheral blood mononuclear cells.

scientific article published in May 2005

Regeneration of megakaryocytopoiesis and thrombopoiesis in vitro from X-irradiated human hematopoietic stem cells

scientific article published on 01 August 2006

Regulation of cell survival and death signals induced by oxidative stress.

scientific article published on September 2008

Responses of regional cerebral blood flow to intravenous administration of thyrotropin releasing hormone in aged rats

scientific article published on August 31, 1992

Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells

scientific article

Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE.

scientific article

Roles of p38 MAPK, PKC and PI3-K in the signaling pathways of NADPH oxidase activation and phagocytosis in bovine polymorphonuclear leukocytes

scientific article published on 01 February 2000

Spin trapping of precursors of thymine damage in X-irradiated DNA.

scientific article published on May 1987

Stimulation of the nucleus basalis of Meynert and substantia innominata produces widespread increases in cerebral blood flow in the frontal, parietal and occipital cortices.

scientific article published in April 1990

Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease

scientific article published on 16 November 2009

Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO)

scientific article published on 01 November 2006

The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice

scientific article published on 10 June 2019

The Leukocyte NADPH Oxidase Subunit p47 : The Role of the Cysteine Residues ⬇️

scientific article published on February 1, 1998

The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells.

scientific article

The effects of (-)-epigallocatechin-3-gallate on the proliferation and differentiation of human megakaryocytic progenitor cells

scientific article published on 01 June 2006

The increased formation of alkali-labile sites by a spin-trapping agent alpha-phenyl-N-tert-butylnitrone in gamma-irradiated frozen aqueous solution of DNA

scientific article published on 01 September 1997

The prospective application of a hypoxic radiosensitizer, doranidazole to rat intracranial glioblastoma with blood brain barrier disruption.

scientific article

The suppression of age-related accumulation of lipid peroxides in rat brain by administration of Rooibos tea (Aspalathus linearis).

scientific article published on August 1995

Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice

scientific article published on 01 May 2007

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells

scientific article

Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography.

scientific article published on September 2008

Visualization of the topographical structure of the anesthetized mouse brain by MR microimaging.

scientific article published in December 1998

X irradiation combined with TNF alpha-related apoptosis-inducing ligand (TRAIL) reduces hypoxic regions of human gastric adenocarcinoma xenografts in SCID mice

scientific article published on 26 January 2008

X irradiation induces the proapoptotic state independent of the loss of clonogenic ability in Chinese hamster V79 cells.

scientific article published on July 2005

alpha-Phenyl N-tert-butyl nitrone (PBN) increases the cortical cerebral blood flow by inhibiting the breakdown of nitric oxide in anesthetized rats.

scientific article published in July 1995

p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not.

scientific article published in November 2001

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