List of works - Andrea Trabocchi

125I-Radiolabeled Morpholine-Containing Arginine–Glycine–Aspartate (RGD) Ligand of αvβ3 Integrin As a Molecular Imaging Probe for Angiogenesis ⬇️

scientific article published on June 14, 2012

3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter.

scientific article published on 5 May 2006

A new family of cinchona-derived amino phosphine precatalysts: application to the highly enantio- and diastereoselective silver-catalyzed isocyanoacetate aldol reaction.

scientific article

A systems biology approach to dissection of the effects of small bicyclic peptidomimetics on a panel of saccharomyces cerevisiae mutants

scientific article

Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis

scientific article published on 01 January 2019

Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype

scientific article published on 17 October 2012

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Carbohydrates in diversity-oriented synthesis: challenges and opportunities

scientific article published on 3 December 2015

Chemical genetics approach to identify new small molecule modulators of cell growth by phenotypic screening of Saccharomyces cerevisiae strains with a library of morpholine-derived compounds.

scientific article

Click-chemistry-derived triazole ligands of arginine-glycine-aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis.

scientific article published on October 2010

Combination of multicomponent KA2 and Pauson-Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

scientific article published on 12 February 2020

Configurationally driven folding of model tetrapeptides containing L- or D-morpholine-3-carboxylic acids as beta-turn nucleators.

scientific article published in June 2009

Convenient route to enantiopure fmoc-protected morpholine-3-carboxylic acid

scientific article published on 28 April 2007

Corrigendum to "Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors" [Bioorg. Med. Chem. 25 (2017) 5077-5083].

scientific article published on 27 October 2017

Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective alpha(v)beta (5) integrin ligand.

scientific article published on 7 March 2009

Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands.

scientific article published on 24 December 2015

Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics: application in the synthesis of an Arg-Gly-Asp (RGD)-containing peptide as an αvβ3 integrin ligand

scientific article

D-proline-based peptidomimetic inhibitors of anthrax lethal factor

scientific article published on 28 August 2012

Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle.

scientific article published on 13 April 2018

Design and Synthesis of Novel Raman Reporters for Bioorthogonal SERS Nanoprobes Engineering

scientific article published in 2022

Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors

scientific article

Design and synthesis of bioactive compounds.

scientific article published in October 2017

Diversity-oriented synthesis as a tool for chemical genetics.

scientific article

Diversity-oriented synthesis of morpholine-containing molecular scaffolds

scientific article published on 01 August 2009

Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5 alpha-reductase 1.

scientific article published in June 2001

Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

scientific article published on 13 March 2014

Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in beta-turn peptides.

scientific article published on 14 December 2009

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.

scientific article

Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors.

scientific article

Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds

scientific article published on 22 March 2019

Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds

scientific article

Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors ⬇️

scientific article published on July 18, 2012

Insight to the binding mode of triazole RGD-peptidomimetics to integrin-rich cancer cells by NMR and molecular modeling.

scientific article published on 14 January 2016

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis.

scientific article published in June 2001

Novel small molecules for the treatment of infections caused by Candida albicans: a patent review (2002-2010).

scientific article published on 18 January 2011

One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation

scientific article published on 27 February 2012

Peptidomimetic toolbox for drug discovery

scientific article published on 07 April 2020

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

scientific article published on 08 September 2014

Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis

scientific article published on 13 January 2015

Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae

scientific article

Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds.

scientific article published on 10 November 2017

Skeletal diversity from carbohydrates: use of mannose for the diversity-oriented synthesis of polyhydroxylated compounds

scientific article published on 11 February 2015

Smart Design of Small-Molecule Libraries: When Organic Synthesis Meets Cheminformatics

scientific article published on 19 March 2019

Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds

scientific article

Structural diversity of bicyclic amino acids.

scientific article published on 15 August 2007

Suzuki reaction of vinyl triflates from six- and seven-membered N-alkoxycarbonyl lactams with boronic acids and esters.

scientific article

Synthesis of a bicyclic delta-amino acid as a constrained Gly-Asn dipeptide isostere

scientific article published on 31 January 2008

Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells.

scientific article published on 19 October 2016

Two-step one-pot synthesis of dihydropyrazinones as Xaa-Ser dipeptide isosteres through morpholine acetal rearrangement

scientific article published on 01 June 2015

Use of click-chemistry in the development of peptidomimetic enzyme inhibitors.

scientific article

List of works by Andrea Trabocchi

125I-Radiolabeled Morpholine-Containing Arginine–Glycine–Aspartate (RGD) Ligand of αvβ3 Integrin As a Molecular Imaging Probe for Angiogenesis ⬇️

3-Aza-6,8-dioxabicyclo[3.2.1]octanes as new enantiopure heteroatom-rich tropane-like ligands of human dopamine transporter.

A new family of cinchona-derived amino phosphine precatalysts: application to the highly enantio- and diastereoselective silver-catalyzed isocyanoacetate aldol reaction.

A systems biology approach to dissection of the effects of small bicyclic peptidomimetics on a panel of saccharomyces cerevisiae mutants

Bicyclic acetals: biological relevance, scaffold analysis, and applications in diversity-oriented synthesis

Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

Carbohydrates in diversity-oriented synthesis: challenges and opportunities

Chemical genetics approach to identify new small molecule modulators of cell growth by phenotypic screening of Saccharomyces cerevisiae strains with a library of morpholine-derived compounds.

Click-chemistry-derived triazole ligands of arginine-glycine-aspartate (RGD) integrins with a broad capacity to inhibit adhesion of melanoma cells and both in vitro and in vivo angiogenesis.

Combination of multicomponent KA2 and Pauson-Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

Configurationally driven folding of model tetrapeptides containing L- or D-morpholine-3-carboxylic acids as beta-turn nucleators.

Convenient route to enantiopure fmoc-protected morpholine-3-carboxylic acid

Corrigendum to "Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors" [Bioorg. Med. Chem. 25 (2017) 5077-5083].

Cyclic DGR-peptidomimetic containing a bicyclic reverse turn inducer as a selective alpha(v)beta (5) integrin ligand.

Cyclic RGD peptidomimetics containing 4- and 5-amino-cyclopropane pipecolic acid (CPA) templates as dual αVβ3 and α5β1 integrin ligands.

Cyclopropane pipecolic acids as templates for linear and cyclic peptidomimetics: application in the synthesis of an Arg-Gly-Asp (RGD)-containing peptide as an αvβ3 integrin ligand

D-proline-based peptidomimetic inhibitors of anthrax lethal factor

Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle.

Design and Synthesis of Novel Raman Reporters for Bioorthogonal SERS Nanoprobes Engineering

Design and synthesis of bicyclic acetals as Beta Secretase (BACE1) inhibitors

Design and synthesis of bioactive compounds.

Diversity-oriented synthesis as a tool for chemical genetics.

Diversity-oriented synthesis of morpholine-containing molecular scaffolds

Effect of C-ring modifications in benzo[c]quinolizin-3-ones, new selective inhibitors of human 5 alpha-reductase 1.

Evaluation of efficacy, pharmacokinetics and tolerability of peptidomimetic aspartic proteinase inhibitors as cream formulation in experimental vaginal candidiasis

Evaluation of stereochemically dense morpholine-based scaffolds as proline surrogates in beta-turn peptides.

Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.

Identification of constrained peptidomimetic chemotypes as HIV protease inhibitors.

Identification of highly potent and selective MMP2 inhibitors addressing the S1' subsite with d-proline-based compounds

Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds

Insight into the structural similarity between HIV protease and secreted aspartic protease-2 and binding mode analysis of HIV-Candida albicans inhibitors ⬇️

Insight to the binding mode of triazole RGD-peptidomimetics to integrin-rich cancer cells by NMR and molecular modeling.

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis.

Novel small molecules for the treatment of infections caused by Candida albicans: a patent review (2002-2010).

One-pot sequential Ti-/Cu-catalysis for tandem amidation/Ullmann-type cyclization: synthesis of model benzodiazepine(di)ones promoted by microwave irradiation

Peptidomimetic toolbox for drug discovery

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Radiosynthesis and micro-SPECT analysis of triazole-based RGD integrin ligands as non-peptide molecular imaging probes for angiogenesis

Relations between Effects and Structure of Small Bicyclic Molecules on the Complex Model System Saccharomyces cerevisiae

Short synthesis of polyfunctional sp3-rich threonine-derived morpholine scaffolds.

Skeletal diversity from carbohydrates: use of mannose for the diversity-oriented synthesis of polyhydroxylated compounds

Smart Design of Small-Molecule Libraries: When Organic Synthesis Meets Cheminformatics

Stereoselective cyclopropanation of serine- and threonine-derived oxazines to access new morpholine-based scaffolds

Structural diversity of bicyclic amino acids.

Suzuki reaction of vinyl triflates from six- and seven-membered N-alkoxycarbonyl lactams with boronic acids and esters.

Synthesis of a bicyclic delta-amino acid as a constrained Gly-Asn dipeptide isostere

Triazole RGD antagonist reverts TGFβ1-induced endothelial-to-mesenchymal transition in endothelial precursor cells.

Two-step one-pot synthesis of dihydropyrazinones as Xaa-Ser dipeptide isosteres through morpholine acetal rearrangement

Use of click-chemistry in the development of peptidomimetic enzyme inhibitors.