List of works - Jean-Michel Sallenave

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

scientific article

Altered secretory leukocyte protease inhibitor expression in the uterine decidua of tubal compared with intrauterine pregnancy

scientific article published on 02 May 2008

Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells.

scientific article

Anti-tumor effect of SLPI on mammary but not colon tumor growth.

scientific article

Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer.

scientific article

Antiviral activity of trappin-2 and elafin in vitro and in vivo against genital herpes.

scientific article published on May 2013

Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.

scientific article

C5a mediates peripheral blood neutrophil dysfunction in critically ill patients

scientific article (publication date: July 2009)

CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo

scientific article published on 16 March 2011

Characterization of the ovine ortholog of secretory leukoprotease inhibitor

scientific article published in August 2005

Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection

scientific article published on 27 February 2015

Deletion of Serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality

scientific article published on 16 May 2011

Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia

scientific article

Differential regulation of secretory leukocyte protease inhibitor and elafin by progesterone

scientific article published on October 2003

Editorial: Neutrophil elastase and the lung: is it degradation, repair, emphysema, or fibrosis? What tilts it left or right?

scientific article published on 01 August 2015

Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens

scientific article published on 01 June 1999

Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation.

scientific article published in September 2003

Elastin fragments induce IL-1beta upregulation via NF-kappaB pathway in melanoma cells

scientific article published on 04 May 2006

Evidence of an alpha 2-macroglobulin-like molecule in plasma of Salamandra salamandra. Structural and functional similarity with human alpha 2-macroglobulin

scientific article published on 01 July 1987

Expression of natural antimicrobials by human placenta and fetal membranes

scientific article published on 28 February 2006

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

scientific article published on 01 October 2012

Gene delivery of the elastase inhibitor elafin protects macrophages from neutrophil elastase-mediated impairment of apoptotic cell recognition

article

House Dust Mite Der p 1 Downregulates Defenses of the Lung by Inactivating Elastase Inhibitors ⬇️

scientific article published on April 10, 2003

Human neutrophil elastase: mediator and therapeutic target in atherosclerosis

scientific article published on 11 January 2008

In vivo adenovirus-mediated expression of human pre-elafin, a potent neutrophil elastase inhibitor

scientific article published on 01 June 1997

Inflammatory Lung Secretions Inhibit Dendritic Cell Maturation and Function via Neutrophil Elastase

article

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

scientific article

Innate immune defences in the human uterus during pregnancy.

scientific article published on 30 July 2007

Internalization of SiO₂ nanoparticles by alveolar macrophages and lung epithelial cells and its modulation by the lung surfactant substitute Curosurf.

scientific article

Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis

scientific article

Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity

scientific article published on January 1, 1992

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep

scientific article published on January 2006

Lung protease/anti-protease network and modulation of mucus production and surfactant activity.

scientific article published on 21 May 2010

Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.

scientific article published in January 2011

Neutrophil DNA contributes to the antielastase barrier during acute lung inflammation.

scientific article published on 10 January 2003

Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease).

scientific article published on March 2008

Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells.

scientific article published on June 1997

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

scientific article

Phagocytic and signaling innate immune receptors: are they dysregulated in cystic fibrosis in the fight against Pseudomonas aeruginosa?

scientific article published on 05 February 2014

Proteases and antiproteases in development, homeostasis and disease: The old, the new, and the unknown...

scientific article published on 22 March 2008

Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway

scientific article published on 08 August 2017

Regulation of Adenovirus-Mediated Elafin Transgene Expression by Bacterial Lipopolysaccharide

article

Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin

scientific article

SLPI and elafin: one glove, many fingers.

scientific article

Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity.

scientific article published on 15 April 2010

Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4(+) lymphocyte proliferation

scientific article published on 17 May 2011

Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci

scientific article published on 26 February 2015

Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator

scientific article

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

scientific article published on March 2017

The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses.

scientific article published on 23 May 2012

The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria

scientific article published on 09 February 2017

The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity

scientific article published on 19 January 2006

Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.

scientific article published on 17 January 2012

Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung.

scientific article published on 3 August 2004

Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment

scientific article published on 05 March 2009

Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C

scientific article

Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

scientific article published on 01 December 2012

WAP domain proteins as modulators of mucosal immunity.

scientific article published on October 2011

List of works by Jean-Michel Sallenave

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

Altered secretory leukocyte protease inhibitor expression in the uterine decidua of tubal compared with intrauterine pregnancy

Annexin A1 processing is associated with caspase-dependent apoptosis in BZR cells.

Anti-tumor effect of SLPI on mammary but not colon tumor growth.

Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer.

Antiviral activity of trappin-2 and elafin in vitro and in vivo against genital herpes.

Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.

C5a mediates peripheral blood neutrophil dysfunction in critically ill patients

CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo

Characterization of the ovine ortholog of secretory leukoprotease inhibitor

Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection

Deletion of Serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality

Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia

Differential regulation of secretory leukocyte protease inhibitor and elafin by progesterone

Editorial: Neutrophil elastase and the lung: is it degradation, repair, emphysema, or fibrosis? What tilts it left or right?

Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens

Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation.

Elastin fragments induce IL-1beta upregulation via NF-kappaB pathway in melanoma cells

Evidence of an alpha 2-macroglobulin-like molecule in plasma of Salamandra salamandra. Structural and functional similarity with human alpha 2-macroglobulin

Expression of natural antimicrobials by human placenta and fetal membranes

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

Gene delivery of the elastase inhibitor elafin protects macrophages from neutrophil elastase-mediated impairment of apoptotic cell recognition

House Dust Mite Der p 1 Downregulates Defenses of the Lung by Inactivating Elastase Inhibitors ⬇️

Human neutrophil elastase: mediator and therapeutic target in atherosclerosis

In vivo adenovirus-mediated expression of human pre-elafin, a potent neutrophil elastase inhibitor

Inflammatory Lung Secretions Inhibit Dendritic Cell Maturation and Function via Neutrophil Elastase

Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

Innate immune defences in the human uterus during pregnancy.

Internalization of SiO₂ nanoparticles by alveolar macrophages and lung epithelial cells and its modulation by the lung surfactant substitute Curosurf.

Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis

Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep

Lung protease/anti-protease network and modulation of mucus production and surfactant activity.

Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.

Neutrophil DNA contributes to the antielastase barrier during acute lung inflammation.

Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease).

Oncostatin M, but not interleukin-6 or leukemia inhibitory factor, stimulates expression of alpha1-proteinase inhibitor in A549 human alveolar epithelial cells.

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

Phagocytic and signaling innate immune receptors: are they dysregulated in cystic fibrosis in the fight against Pseudomonas aeruginosa?

Proteases and antiproteases in development, homeostasis and disease: The old, the new, and the unknown...

Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway

Regulation of Adenovirus-Mediated Elafin Transgene Expression by Bacterial Lipopolysaccharide

Regulation of pulmonary and systemic bacterial lipopolysaccharide responses in transgenic mice expressing human elafin

SLPI and elafin: one glove, many fingers.

Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity.

Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4(+) lymphocyte proliferation

Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci

Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses.

The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria

The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity

Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.

Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung.

Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment

Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C

Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung

WAP domain proteins as modulators of mucosal immunity.