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List of works by Wai-Ping Fung-Leung

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

scientific article published on August 2005

ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism.

scientific article

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts

scientific article published on 01 June 1996

Altered Antigen Presentation in Mice Lacking H2-O ⬇️

scientific article published on February 1, 1998

Antigen presentation and T cell development in H2-M-deficient mice

scientific journal article

Behavioral characterization of mice lacking histamine H(3) receptors.

scientific article

Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension.

scientific article published on 19 August 2010

Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway

scientific article published on 25 October 2011

CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice.

scientific article published in January 1996

CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule

scientific article published on 01 March 1993

CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny

scientific article published on 01 January 1993

Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1

scientific journal article

Characteristics of fetal thymus-derived T cell receptor gamma delta intestinal intraepithelial lymphocytes

scientific article published on 01 August 1994

Chronic black tea extract consumption improves endothelial function in ovariectomized rats

scientific article published on 15 August 2015

Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats.

scientific article published on 27 July 2012

Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i

scientific article

Comparison of RNA-Seq and microarray in transcriptome profiling of activated T cells

scientific article

CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion

scientific article published on March 2006

Defective CD8+ T cell activation and cytolytic function in the absence of LFA-1 cannot be restored by increased TCR signaling

scientific article published on 01 November 1999

Down-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance

scientific article published on 01 October 1995

Embryonic stem cells and homologous recombination ⬇️

scientific article published on April 1, 1992

Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery.

scientific article published on 9 March 2006

Endothelium-independent relaxation to raloxifene in porcine coronary artery

scientific article published on 20 October 2006

Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis

scientific article published on 20 March 2019

Gender-biased regulation of human IL-17-producing cells in vitro by peptides corresponding to distinct HLA-DRB1 allele-coded sequences

scientific article published on 01 July 2013

Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting

scientific article published on 01 April 1992

Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting.

scientific article published on January 1992

Histamine H4 receptor antagonists: the new antihistamines?

scientific article

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

scientific article

Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

scientific article published on May 2004

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.

scientific article published on 29 September 2017

IgE-dependent mast cell activation potentiates airway responses in murine asthma models

scientific article published in August 2002

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression ⬇️

scientific article published on December 1, 1991

Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor

scientific article published on 13 January 2020

Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1.

scientific article published on December 1996

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells ⬇️

scientific article published on November 15, 1993

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

scientific article

Intestinal T cells in CD8 alpha knockout mice and T cell receptor transgenic mice.

scientific article published in January 1995

Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice

scientific article published on 01 May 1992

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

scientific article

Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells.

scientific article published in September 1995

Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors.

scientific article published in February 2003

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

scientific journal article

Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.

scientific article published on 2 December 2011

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

scientific article

PI3Kγ kinase activity is required for optimal T-cell activation and differentiation.

scientific article published on 9 October 2013

Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner.

scientific article published in May 1997

Peripheral deletion of mature CD8+ antigen-specific T cells after in vivo exposure to male antigen

scientific article published on 01 June 1992

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

scientific article published on December 2016

Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function

scientific article

Phosphoinositide 3-kinase gamma (PI3Kgamma) inhibitors for the treatment of inflammation and autoimmune disease

scientific article published on January 2010

Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor.

scientific article published on 20 May 2008

RORγt and RORα signature genes in human Th17 cells

scientific article published on August 2017

Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet

scientific article published on 6 October 2011

Raloxifene modulates pulmonary vascular reactivity in spontaneously hypertensive rats

scientific article published on 01 June 2007

Raloxifene relaxes rat intrarenal arteries by inhibiting Ca2+ influx.

scientific article published on 15 February 2005

Raloxifene, tamoxifen and vascular tone.

scientific article published on August 2007

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

scientific article published on September 1994

Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts

scientific article published on 01 April 1998

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers

scientific article

T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation

scientific article published on 19 September 2018

Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses.

scientific article published on March 2000

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.

scientific article

Tepoxalin, a novel immunomodulatory compound, synergizes with CsA in suppression of graft-versus-host reaction and allogeneic skin graft rejection

scientific article published on 01 August 1995

The lack of CD8 alpha cytoplasmic domain resulted in a dramatic decrease in efficiency in thymic maturation but only a moderate reduction in cytotoxic function of CD8+ T lymphocytes

scientific article published on 01 November 1993

Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation.

scientific article published on 25 February 2010

Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

scientific article published in August 1997

Thymic selection of cytotoxic T cells independent of CD8 alpha-Lck association

scientific article

Use of a human skin-grafted nude mouse model for the evaluation of topical retinoic acid treatment

scientific article published on 01 April 1994

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