List of works by Thomas Williams

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus

scientific article

A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots

scientific article published on 24 April 2014

A polymorphism of intercellular adhesion molecule-1 is associated with a reduced incidence of nonmalarial febrile illness in Kenyan children

scientific article

Acquisition of growth-inhibitory antibodies against blood-stage Plasmodium falciparum

scientific article

Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1.

scientific article published on 16 August 2008

Adult non-communicable disease mortality in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System sites

scientific article

Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study

scientific article (publication date: June 2016)

An assessment of the impact of host polymorphisms on Plasmodium falciparum var gene expression patterns among Kenyan children

scientific article

An immune basis for malaria protection by the sickle cell trait

scientific article

An observational study of children with sickle cell disease in Kilifi, Kenya

scientific article published on 23 July 2009

Association of the GNAS locus with severe malaria

scientific article published on 26 October 2008

Author Correction: Investigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya

scientific article published on 23 December 2020

B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area

scientific article published on 13 April 2005

Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study

scientific article published on 09 September 2009

Bacteremia among children admitted to a rural hospital in Kenya

scientific article published in January 2005

Balancing act: haemoglobinopathies and malaria

scientific article published on 23 March 2012

Blood Pressure and Arterial Stiffness in Kenyan Adolescents With α+Thalassemia

scientific article published on 5 April 2017

Blood Pressure and Arterial Stiffness in Kenyan Adolescents with the Sickle Cell Trait

scientific article published on 12 June 2017

Blood groups and malaria: fresh insights into pathogenesis and identification of targets for intervention

scientific article

Burden of disease in adults admitted to hospital in a rural region of coastal Kenya: an analysis of data from linked clinical and demographic surveillance systems

scientific article

CISH and susceptibility to infectious diseases

scientific article

Case Report: β-thalassemia major on the East African coast

scientific article published on 13 July 2022

Cause-specific childhood mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

scientific article

Cause-specific mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites

scientific article

Causes of death among persons of all ages within the Kilifi Health and Demographic Surveillance System, Kenya, determined from verbal autopsies interpreted using the InterVA-4 model

scientific article

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

scientific article published on 09 January 2017

Characterising demographics, knowledge, practices and clinical care among patients attending sickle cell disease clinics in Eastern Uganda

scientific article published on 04 May 2020

Characterization of a Plasmodium falciparum macrophage-migration inhibitory factor homologue

scientific article (publication date: 15 March 2007)

Children's Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

scientific article published on 11 October 2017

Ciguatera poisoning in Vanuatu

scientific article published on February 2003

Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters

scientific article

Co-trimoxazole or multivitamin multimineral supplement for post-discharge outcomes after severe anaemia in African children: a randomised controlled trial

scientific article published on 01 October 2019

Cohort Profile: The Kilifi Vaccine Monitoring Study

scientific article

Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children

scientific article

Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study

scientific article

Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria

scientific article

Consulting communities on feedback of genetic findings in international health research: sharing sickle cell disease and carrier information in coastal Kenya

scientific article

Copy number, linkage disequilibrium and disease association in the FCGR locus

scientific article

Correction: Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations.

scientific article published on 27 June 2013

Coverage and timeliness of vaccination and the validity of routine estimates: Insights from a vaccine registry in Kenya

article

Declining malaria transmission differentially impacts on the maintenance of humoral immunity to Plasmodium falciparum in children

scientific article published on 2 August 2017

Defining childhood severe falciparum malaria for intervention studies

scientific article

Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya

scientific article

Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction

scientific article published on 7 July 2017

Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance

scientific article published on 11 November 2016

Effect of Previous Exposure to Malaria on Blood Pressure in Kilifi, Kenya: A Mendelian Randomization Study

scholarly article by Anthony O Etyang et al published 19 March 2019 in Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study.

scientific article published on 15 April 2019

Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review

scientific article published on 13 February 2020

Environmental Correlation Analysis for Genes Associated with Protection against Malaria

scientific article published on 6 January 2016

Epidemiological studies of the 'non-specific effects' of vaccines: I--data collection in observational studies

scientific article

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children

scientific article published on 29 January 2014

Erratum to "Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia" [EBioMedicine 1 (2014) 29-36].

scientific article published on 19 May 2015

Erratum: Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: deviations from Hardy-Weinberg equilibrium

article

Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection

scientific article

Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda

scholarly article by Peter Olupot-Olupot et al published 4 October 2018 in Wellcome Open Research

Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe  anaemia in hospitalised children in Eastern Uganda.

scientific article published in January 2018

Excess child mortality after discharge from hospital in Kilifi, Kenya: a retrospective cohort analysis

scientific article published on 13 July 2011

Experiences with community engagement and informed consent in a genetic cohort study of severe childhood diseases in Kenya

scientific article (publication date: 15 July 2010)

Falciparum malaria: current therapeutic challenges

scientific article published in October 2004

Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort

scholarly article by Michelle K. Muthui et al published 5 April 2019 in Wellcome Open Research

Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort

scientific article published on 28 May 2019

Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

scientific article

Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya

scientific article

Genetic variation in is associated with bacteremia secondary to diverse pathogens in African children

article published in the Proceedings of the National Academy of Sciences of the United States of America

Genome-wide and fine-resolution association analysis of malaria in West Africa

scientific article

Geographic access to care is not a determinant of child mortality in a rural Kenyan setting with high health facility density

scientific article

Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions

scientific article

Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

scientific article

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

scientific article published on 25 October 2012

Global migration and the changing distribution of sickle haemoglobin: a quantitative study of temporal trends between 1960 and 2000.

scientific article

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

scientific article

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition

journal article published in 2015

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study

scientific article

HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria

scientific article

HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites.

scientific article

Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub-Saharan Africa

scientific article

Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malaria

scientific article

Haemoglobinopathies and resistance to malaria

scientific article published on January 2003

Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area.

scientific article published on 12 June 2008

Heritability of malaria in Africa

scientific article

High Frequency of Blackwater Fever Among Children Presenting to Hospital With Severe Febrile Illnesses in Eastern Uganda

scientific article published on April 2017

High levels of serum antibodies to merozoite surface protein 2 of Plasmodium falciparum are associated with reduced risk of clinical malaria in coastal Kenya

scientific article

High mortality from Plasmodium falciparum malaria in children living with sickle cell anemia on the coast of Kenya

scientific article

Homozygosity and risk of childhood death due to invasive bacterial disease

scientific article

How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children

scientific article published on 22 September 2020

How do hemoglobins S and C result in malaria protection?

scientific article published on 12 October 2011

Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria

scientific article

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

article

Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis

scientific article published on 08 March 2017

Human genetic resistance to malaria

scientific article published on January 2009

Human genetics and malaria resistance

scientific article published on 04 March 2020

Human red blood cell polymorphisms and malaria

scientific article

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

scientific article published on 10 January 2019

Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models

scientific article published on 6 August 2015

Immediate Transfusion in African Children with Uncomplicated Severe Anemia

scientific article published on 01 August 2019

Impact of 10-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya

scholarly article published 18 July 2018

Imputation-based meta-analysis of severe malaria in three African populations

scientific article

Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya

scientific article

Informing thresholds for paediatric transfusion in Africa: the need for a trial

article

Informing thresholds for paediatric transfusion in Africa: the need for a trial

scientific article published on 12 August 2019

Invasive Group A Streptococcus Infection among Children, Rural Kenya

scientific article published on February 2016

Invasive Salmonellosis in Kilifi, Kenya

scientific article

Investigating the potential for ethnic group harm in collaborative genomics research in Africa: is ethnic stigmatisation likely?

scientific article published on 16 June 2012

Iron Status and Associated Malaria Risk Among African Children

scientific article published on 01 May 2019

Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis

scientific article

Iron deficiency and malaria among children living on the coast of Kenya

scientific article published on 2 July 2004

Knowing who to trust: exploring the role of 'ethical metadata' in mediating risk of harm in collaborative genomics research in Africa

scientific article

Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations

scientific article

Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12.

scientific article

Linking health facility data from young adults aged 18-24 years to longitudinal demographic data: Experience from The Kilifi Health and Demographic Surveillance System

article

Linking health facility data from young adults aged 18-24 years to longitudinal demographic data: Experience from The Kilifi Health and Demographic Surveillance System

scientific article published on 01 January 2017

Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya

scientific article

Malaria and nutritional status in children living on the coast of Kenya

scientific article published in December 2004

Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya

scientific article published on July 2009

Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization

scientific article

Malaria mortality in Africa and Asia: Evidence from INDEPTH health and demographic surveillance system sites

scientific article

Management of severe malaria in children: proposed guidelines for the United Kingdom

scientific article

Micro-epidemiological structuring of Plasmodium falciparum parasite populations in regions with varying transmission intensities in Africa

scientific article (publication date: 14 February 2017)

Mortality from external causes in Africa and Asia: evidence from INDEPTH Health and Demographic Surveillance System Sites

scientific article

Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania

scientific article

Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait

scientific article

Nutritional iron status in children with alpha+ thalassemia and the sickle cell trait in a malaria endemic area on the coast of Kenya

scientific article published in April 2005

Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania

scientific article

Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: deviations from Hardy-Weinberg equilibrium

scientific article

Online biomedical resources for malaria-related red cell disorders

scientific article

Parvovirus B19 infection and severe anaemia in Kenyan children: a retrospective case control study

scientific article

Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial

scientific article published in 2023

Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

scientific article

Plasmodium falciparum cytoadherence to ICAM-1 is associated with cerebral malaria.

scientific article

Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children

scientific article published on 26 May 2016

Population Turnover in Remote Oceania Shortly After Initial Settlement

scholarly article published 19 February 2018

Population Turnover in Remote Oceania Shortly after Initial Settlement.

scientific article published on 26 February 2018

Positive selection of a CD36 nonsense variant in sub-saharan Africa, but no association with severe malaria phenotypes

scientific article published on 29 April 2009

Pregnancy-related mortality in Africa and Asia: Evidence from INDEPTH health and demographic surveillance system sites

scientific article

Prevalence of Inherited Hemoglobin Disorders and Relationships with Anemia and Micronutrient Status among Children in Yaoundé and Douala, Cameroon

scientific article

Profile: The Kilifi Health and Demographic Surveillance System (KHDSS)

scientific article (publication date: June 2012)

Prospective Observational Study of Incidence and Preventable Burden of Childhood Tuberculosis, Kenya

scientific article published in March 2018

Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub-Saharan Africa

scientific article published on 10 January 2018

Red blood cell defects and malaria

scientific article published on 9 June 2006

Red blood cell tension protects against severe malaria in the Dantu blood group

scientific article published on 16 September 2020

Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study

scientific article

Remembering the forgotten non-communicable diseases

scientific article published on 22 October 2014

Resistance to malaria through structural variation of red blood cell invasion receptors

scientific article published on 18 May 2017

Resistance to malaria through structural variation of red blood cell invasion receptors

scholarly article published 26 October 2016

Risk factors for high cerebral blood flow velocity and death in Kenyan children with Sickle Cell Anaemia: role of haemoglobin oxygen saturation and febrile illness

scientific article

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4. ⬇️

scientific article

Rotavirus genetic diversity, disease association, and temporal change in hospitalized rural Kenyan children

scientific article

Routine paediatric sickle cell disease (SCD) outpatient care in a rural Kenyan hospital: utilization and costs

scientific article

Sensitivity of hospital-based surveillance for severe disease: a geographic information system analysis of access to care in Kilifi district, Kenya

scientific article

Sickle cell disease and malaria morbidity: a tale with two tails

scientific article

Sickle cell disease in Africa: a neglected cause of early childhood mortality

scientific article published on December 2011

Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases

scientific article

Sickle-cell disease

scientific article

Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa

scientific article published on 18 January 2018

Social autopsy: INDEPTH Network experiences of utility, process, practices, and challenges in investigating causes and contributors to mortality

scientific article published on 5 August 2011

Spatial distribution of G6PD deficiency variants across malaria-endemic regions

scientific article

Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome

scientific article

Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya

scientific article

Subphenotypes of sickle cell disease in Africa.

scientific article published in November 2017

Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo

scientific article

Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya

scientific article published on 16 December 2008

The Jamaican historical experience of the impact of educational interventions on sickle cell disease child mortality

scientific article published on June 2012

The clinical epidemiology of sickle cell anemia In Africa.

scientific article published on 23 November 2017

The clinical spectrum of severe childhood malaria in Eastern Uganda

scientific article published on 03 September 2020

The distribution of haemoglobin C and its prevalence in newborns in Africa

scientific article

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya

scientific article

The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

scientific article published on 04 September 2019

The frequency and severity of epistaxis in children with sickle cell anaemia in eastern Uganda: a case-control study

scientific article published on 7 September 2017

The frequency of BDCA3-positive dendritic cells is increased in the peripheral circulation of Kenyan children with severe malaria

scientific article

The genetic risk of acute seizures in African children with falciparum malaria

scientific article published on 24 April 2013

The global distribution of the Duffy blood group

scientific article

The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya

scientific article published on 07 February 2007

The impact of 10-valent Pneumococcal Conjugate Vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children

scholarly article published 18 July 2018

The indirect health effects of malaria estimated from health advantages of the sickle cell trait

scientific article published on 20 February 2019

The use of cryopreserved mature trophozoites in assessing antibody recognition of variant surface antigens of Plasmodium falciparum-infected erythrocytes

scientific article published in May 2004

The “Difficult Patient” Conundrum in Sickle Cell Disease in Kenya: Complex Sociopolitical Problems Need Wide Multidimensional Solutions

scholarly article by Vicki M. Marsh et al published April 2013 in American Journal of Bioethics

Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia

scientific article

Transfusion Volume for Children with Severe Anemia in Africa

scientific article published on 01 August 2019

Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

scientific article

Transmission-dependent tolerance to multiclonal Plasmodium falciparum infection

scientific article published on October 2009

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations

scientific article published on February 2009

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia.

scientific article published on 25 April 2018

Validating physician-certified verbal autopsy and probabilistic modeling (InterVA) approaches to verbal autopsy interpretation using hospital causes of adult deaths

scientific article

Verbal autopsy as a tool for identifying children dying of sickle cell disease: a validation study conducted in Kilifi district, Kenya

scientific article

Vitamin D Status Is Not Associated with Cognitive or Motor Function in Pre-School Ugandan Children

scientific article published on 03 June 2020

β-Thalassemia pathogenic variants in a cohort of children from the East African coast

scientific article published on 11 May 2020

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