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List of works by Richard McCulloch

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections

scientific article published on 03 April 2019

Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania

scientific article published on 01 December 2018

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication

scientific article published on 01 July 2020

Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?

scientific article published on 7 November 2016

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

scientific article published on 15 November 2018

Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

scientific article published on 08 September 2020

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

scientific article

Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome

article

Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation.

scientific article published on 26 May 2016

RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse

scientific article published on 21 July 2017

Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion

article

RibonucleaseH1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion

article

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

scientific article published on 13 July 2020

The ATR kinase of Trypanosoma brucei links DNA damage signalling and monoallelic control of surface antigen gene expression during antigenic variation

article

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

scientific article

The protozoan nucleus

scientific article published on 12 May 2016

Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration

scientific article published on 06 December 2019

Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation

scientific article published on 01 September 2019

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