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List of works by Haruhisa Kikuchi

1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1.

scientific article

5,19-cyclo-9beta,10xi-androstane-3,17-dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment.

scientific article published on 12 October 2007

A novel carbon skeletal trichothecane, tenuipesine A, isolated from an entomopathogenic fungus, Paecilomyces tenuipes.

scientific article published in November 2004

A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells.

scientific article published on 25 May 2011

Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.

scientific article published on 15 February 2016

Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans.

scientific article published on 16 December 2016

An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes

scientific article published on 22 February 2019

Anti-leukemic activities of Dictyostelium secondary metabolites: a novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells

scientific article published on 06 September 2006

Antimicrobial Activities of Dictyostelium Differentiation-Inducing Factors and Their Derivatives

scientific article published on 27 April 2019

Antimicrobial and antioxidant properties of methanol extract, fractions and compounds from the stem bark of Entada abyssinica Stend ex A. Satabie

scientific article

Antimycobacterial flavonoids from the leaf extract of Galenia africana

scientific article published in December 2009

Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells.

scientific article

Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation

scientific article published on 19 January 2011

Atg1 allows second-signaled autophagic cell death in Dictyostelium ⬇️

scientific article published on May 1, 2011

Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-1.

scientific article published on 12 December 2008

Biological Activities of Novel Derivatives of Differentiation-Inducing Factor 3 from Dictyostelium discoideum.

scientific article published in January 2017

Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium.

scientific article published on 31 October 2008

Construction of a Meroterpenoid-like Compounds Library Based on Diversity-Enhanced Extracts

scientific article published on 13 December 2018

Correction to "Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons"

scientific article published on 05 February 2019

Correction: ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor

scientific article published on 11 September 2015

Defects in the synthetic pathway prevent DIF-1 mediated stalk lineage specification cascade in the non-differentiating social amoeba, Acytostelium subglobosum.

scientific article published on 29 May 2014

Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid-stimulated migration of murine osteosarcoma LM8 cells

scientific article published on 6 June 2015

Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells ⬇️

scientific article published on January 14, 2011

Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo.

scientific article published on 17 March 2013

Design and Synthesis of Structure-Simplified Derivatives of Gonytolide for the Promotion of Innate Immune Responses

scientific article published on 15 April 2016

Development of a Terpenoid Alkaloid-like Compound Library Based on the Humulene Skeleton.

scientific article

Development of diversity-enhanced extracts of Curcuma zedoaria and their new sesquiterpene-like compounds

scientific article published on 19 March 2014

Development of novel DIF-1 derivatives that selectively suppress innate immune responses

scientific article

Dictyopyrones, novel alpha-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum

scientific article published on 01 September 2005

Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery

scientific article published on 21 December 2018

Differentiation-inducing factor-1 prevents hepatic stellate cell activation through inhibiting GSK3β inactivation

scientific article published on 30 September 2019

Effect of brefelamide on proliferation of 1321N1 human astrocytoma cells induced by glial cell line-derived neurotrophic factor.

scientific article published in January 2018

Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in D. discoideum.

scientific article

Exploitation of the derivatives of Dictyostelium differentiation-inducing factor-1, which promote glucose consumption in mammalian cells.

scientific article published on 9 September 2008

Exploration of a new type of antimalarial compounds based on febrifugine.

scientific article published on July 2006

Furanodictine A and B: amino sugar analogues produced by cellular slime mold Dictyostelium discoideum showing neuronal differentiation activity

scientific article published on 01 October 2001

Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum.

scientific article published on 19 September 2016

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.

scientific article

Halogen-Substituted Derivatives of Dictyostelium Differentiation-Inducing Factor-1 Suppress Serum-Induced Cell Migration of Human Breast Cancer MDA-MB-231 Cells in Vitro

scientific article published on 28 June 2019

Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells.

scientific article published on 5 August 2016

Induction of Osteopontin by Dengue Virus-3 Infection in THP-1 Cells: Inhibition of the Synthesis by Brefelamide and Its Derivative.

scientific article published on 29 March 2017

Inhibition of inflammatory-molecule synthesis in THP-1 cells stimulated with phorbol 12-myristate 13-acetate by brefelamide derivatives

scientific article published on 19 August 2019

Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.

scientific article published on 16 July 2010

Isolation of a Cyclic Depsipetide, Aspergillicin F, and Synthesis of Aspergillicins with Innate Immune-Modulating Activity

scientific article published on 14 August 2015

Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds

scientific article published on 18 September 2017

Labdane-type diterpenes and flavones from Dodonaea viscosa ⬇️

scientific article published on March 20, 2012

Metarhizin A suppresses cell proliferation by inhibiting cytochrome c oxidase activity.

scientific article published in April 2014

Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum [corrected]

scientific article (publication date: 2013)

Monoterpene Indole Alkaloid-Like Compounds Based on Diversity-Enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity

scientific article published on 10 November 2016

Novel acyl alpha-pyronoids, dictyopyrone A, B, and C, from Dictyostelium cellular slime molds

scientific article published on 01 February 2000

Novel chlorinated dibenzofurans isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities.

scientific article published on 23 May 2013

Novel spirocyclic trichothecanes, spirotenuipesine A and B, isolated from entomopathogenic fungus, Paecilomyces tenuipes.

scientific article

Oral administration of Dictyostelium differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin-induced diabetic rats

scientific article

Peltophorum africanum, a traditional South African medicinal plant, contains an anti HIV-1 constituent, betulinic acid

scientific article

Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.

scientific article

Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2.

scientific article published on 28 January 2016

Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1

scientific article published on 21 April 2010

Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum.

scientific article published on 15 April 2014

Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors.

scientific article published on 24 July 2009

Removal of the E-Olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons

scientific article published on 05 November 2018

Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity

Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase

scientific article

Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells

scientific article published on 01 September 2005

Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007

scientific article published on 03 September 2019

Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis

scientific article

Structures of the dimeric and monomeric chromanones, gonytolides A-C, isolated from the fungus Gonytrichum sp. and their promoting activities of innate immune responses.

scientific article published on 9 August 2011

Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives ⬇️

scientific article published on February 3, 2011

Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial

scientific article published on 25 January 2014

Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities

scientific article published on 22 November 2014

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

scientific article

The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor.

scientific article published in January 2013

Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds

scientific article published on 23 June 2020

Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold

scientific article

ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with celastramycin A, a potential immune suppressor.

scientific article

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