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List of works by Michael J Blackman

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.

scientific article published on 01 January 2020

A multifunctional serine protease primes the malaria parasite for red blood cell invasion

scientific article (publication date: 18 March 2009)

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress ⬇️

scientific article

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

scientific article published on 19 February 2018

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes

scientific article

An inhibitory antibody blocks interactions between components of the malarial invasion machinery

scientific article

Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations

scientific article published on 18 September 2017

Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion ⬇️

scientific article

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor.

scientific article

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scientific article

Correction: Juxtamembrane Shedding of Plasmodium falciparum AMA1 Is Sequence Independent and Essential, and Helps Evade Invasion-Inhibitory Antibodies

scientific article published on 29 February 2012

Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

scientific article published on 28 May 2014

Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

scientific article published on 24 February 2005

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery

scientific article published on 10 May 2019

Cyclic Nucleotide (cAMP and cGMP) Assays and Capture ELISA for Quantitative Analysis of Plasmodium falciparum Blood-stage Egress

scientific article published on March 2014

Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum

scientific article

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens

scientific article published in September 2005

Essentiality of Plasmodium falciparum plasmepsin V

scientific article published in PLoS ONE

Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling

scientific article

Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1

scientific article (publication date: August 2003)

Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease

scientific article

High-Level Expression of the Malaria Blood-Stage Vaccine Candidate Plasmodium falciparum Apical Membrane Antigen 1 and Induction of Antibodies That Inhibit Erythrocyte Invasion.

scientific article published in October 2002

High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion ⬇️

scientific article

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite

scientific article (publication date: 25 September 2006)

Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies ⬇️

scientific article

Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony.

scientific article published on 9 March 2021

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

scientific article (publication date: May 2013)

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface

scientific article

Molecular identification of a malaria merozoite surface sheddase

scientific article

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress

scientific article

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1.

scholarly article

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion ⬇️

scientific article

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle

scientific article (publication date: April 2015)

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

scientific article

Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity

scientific article

Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte

scientific article

Publisher Correction: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

scientific article published on 01 April 2018

Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle ⬇️

scientific article published on March 26, 2013

Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function

scientific article published on 16 March 2020

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes

scientific article (publication date: 14 December 2007)

The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes

scientific article

The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion. ⬇️

scientific article published in September 2019

The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake ⬇️

scientific article (publication date: 2 March 2017)

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

scientific article

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

scientific article published on 08 December 2020

The parasitophorous vacuole of the blood-stage malaria parasite

scientific article published on 24 January 2020

Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity

scientific article published on 8 September 2005

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