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List of works by Richard K Haynes

11-Azaartemisinin cocrystals with preserved lactam : acid heterosynthons

A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine

scientific article

A new resolution procedure for the preparation of both (R)-(+)- and (S)-(-)-4-tert-butoxycyclopent-2-enone from racemic 4-tert-butoxycyclopent-2-enone and conversion of (R)-(+)-4-tert-butoxycyclopent-2-enone into (R)-(+)-4-acetoxycyclopent-2-enone. A

A novel endoperoxide and related sesquiterpenes from Artemisia annua which are possibly derived from allylic hydroperoxides

A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts

scientific article

A route to prostaglandin precursors from 1-(phenylthio)-2-octenyllithium

A simple route to (R)-(+)-4-t-butoxycyclopent-2-enone

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

scientific article

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

scientific article (publication date: February 2012)

Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology.

scientific article published on 7 May 2011

Absorptive and Secretory Transport of Selected Artemisinin Derivatives Across Caco-2 Cell Monolayers

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Asexual and Transmissible Malaria Parasites.

scientific article published on 8 December 2017

Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities

scientific article published on 6 December 2017

Adapting Clofazimine for Treatment of Cutaneous Tuberculosis by Using Self-Double-Emulsifying Drug Delivery Systems

scientific article published in 2022

Air-stable P-stereogenic secondary phosphine oxides as chiral monodentate ligands for asymmetric catalytic carboncarbon bond formation

scholarly article by Wei-Min Dai et al published September 2003 in Tetrahedron: Asymmetry

An ADME and Pharmacokinetic Study of Novel TB-Active Decoquinate Derivatives

scientific article published on 18 February 2019

An Efficient Stereoselective Synthesis of a Racemic CD-Intermediate of Vitamin D

An Improved Method for the Isolation of Qinghao (Artemisinic) Acid from Artemisia annua

scientific article published on 01 December 1993

An improved preparation of the desmethyl qinghao acid precursor of (±)-6,9-desmethylqinghaosu

Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

scientific article published on 30 April 2019

Anticancer properties of distinct antimalarial drug classes

scientific article (publication date: 2013)

Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.

scientific article published on 2 March 2007

Aprotic conjugate addition of allyllithium reagents bearing polar groups to cyclic enones. 1. 3-Alkylallyl systems

article

Aprotic conjugate addition of allyllithium reagents bearing polar groups to cyclic enones. 2. 2-Alkyl-, 2,3-dialkyl- and 1,3-dialkylallyl systems

article

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

scientific article

Artemisinin and derivatives: the future for malaria treatment?

scientific article

Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth

scientific article published on 5 March 2007

Artemisinins: activities and actions

scientific article

Artemisinins: mechanisms of action and potential for resistance

scientific article

Artemisinins: their growing importance in medicine

scientific article

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

scientific article published on 27 July 2018

Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model

scientific article published on 27 July 2009

Artemisone demonstrates synergistic antiviral activity in combination with approved and experimental drugs active against human cytomegalovirus

scientific article published on 22 October 2019

Artemisone effective against murine cerebral malaria

scientific article

Artemisone inhibits in vitro and in vivo propagation of Babesia bovis and B. bigemina parasites

scientific article published on 30 October 2013

Artemisone uptake in Plasmodium falciparum-infected erythrocytes

scientific article

Artemisone--a highly active antimalarial drug of the artemisinin class

scientific article published in March 2006

Artesunate and dihydroartemisinin (DHA): unusual decomposition products formed under mild conditions and comments on the fitness of DHA as an antimalarial drug

scientific article

Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro

scientific article published on 6 October 2014

Catalysed oxygenation of allylic hydroperoxides derived from qinghao (artemisinic) acid. Conversion of qinghao acid into dehydroginghaosu (artemisitene) and qinghaosu (artemisinin)

Chiral bisphosphinite metalloligands derived from a P-chiral secondary phosphine oxide.

scientific article

Cocrystals of the antimalarial drug 11-azaartemisinin with three alkenoic acids of 1:1 or 2:1 stoichiometry

scientific article published on 24 May 2018

Comparative ex vivo activity of novel endoperoxides in multidrug-resistant plasmodium falciparum and P. vivax

scientific article

Completely stereoselective PC bond formation via base-induced [1,3]- and [1,2]-intramolecular rearrangements of aryl phosphinates, phosphinoamidates and related compounds: generation of P-chiral β-hydroxy, β-mercapto- and α-amino tertiary phosp

Considerations on the Mechanism of Action of Artemisinin Antimalarials: Part 1 - The 'Carbon Radical' and 'Heme' Hypotheses

scientific article

Convenient access both to highly antimalaria-active 10-arylaminoartemisinins, and to 10-alkyl ethers including artemether, arteether, and artelinate

scientific article published in April 2005

Copper(II) Trifluoromethanesulfonate-Induced Cleavage Oxygenation of Allylic Hydroperoxides Derived from Qinghao Acid in the Synthesis of Qinghaosu Derivatives: Evidence for the Intermediacy of Enols

scientific article published in 1995

Diastereo- and Regioselectivity in the Reactions of Dilithiated Allylic Secondary Amides with Cyclopent-2-enone

Die Oxidation von Orcin mit K3[Fe(CN)6] im Strömungsrohr

Differential effects on angiogenesis of two antimalarial compounds, dihydroartemisinin and artemisone: implications for embryotoxicity

scientific article

Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle

scientific article

Dual production of solar energy and important plant-derived active pharmaceutical ingredients: Artemisinin, a pilot study

scientific article published in 2022

Elimination of Schistosoma mansoni in infected mice by slow release of artemisone

scientific article

Elucidation of the Solution Conformations of Loloatin C by NMR Spectroscopy and Molecular Simulation

Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: A test of N-glycosylation methodologies on a lipophilic peroxide

Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum

scientific article published on 08 June 2009

Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes

scientific article

Facile Preparation of -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities

Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: relationship with flavoenzyme function and antimalarial mechanism of action

scientific article published on August 2010

First assessment in humans of the safety, tolerability, pharmacokinetics, and ex vivo pharmacodynamic antimalarial activity of the new artemisinin derivative artemisone

scientific article published on 16 June 2008

Formulation of Natural Oil Nano-Emulsions for the Topical Delivery of Clofazimine, Artemisone and Decoquinate

scientific article published on 07 August 2018

From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements

scientific article

Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria

scientific article (publication date: 2013)

HMPA-Mediated conjugate addition of alkyl- and phenylthioallyl anions to cyclopentenone

article

Hexamethylphosphoramide-mediated conjugate addition of (alkylthio)-, (phenylthio)-, and (phenylseleno)allyllithium reagents to 2-cyclopentenone

article

Highly Antimalaria-Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity

scientific article published on 01 March 2004

Highly enantioselective phenyl transfer to aryl aldehydes catalyzed by easily accessible chiral tertiary aminonaphthol

scientific article

In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis

scientific article published on 22 October 2019

In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori

scientific article published on 6 May 2016

In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells

scientific article published on 14 August 2015

In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts

scientific article published on 14 April 2015

In vitro skin permeation of artemisone and its nano-vesicular formulations

scientific article published on 27 February 2016

In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents

scientific article

Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives

scientific article published on 19 August 2014

Interaction of artemisinins with oxyhemoglobin Hb-FeII, Hb-FeII, carboxyHb-FeII, heme-FeII, and carboxyheme FeII: significance for mode of action and implications for therapy of cerebral malaria

scientific article published in December 2009

Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action

scientific article published on 30 October 2012

Iron(III) and copper(II) catalysed transformations of fatty acid hydroperoxides: efficient generation of peroxy radicals with copper(II) trifluoromethanesulphonate

Iron(III)-induced cleavage of cyclic allylic hydroperoxides to dicarbonyl compounds under aprotic conditions

Kinetically controlled, stereoselective formation of vinylic sulfones by conjugate addition of lithiated 3-alkylallylic sulfones to cyclic enones

article

Lewis acid catalysed oxygenation of ergosteryl acetate by triplet oxygen

Low-Temperature X-ray Crystal-Structure Analysis of the Thermally Unstable Lithiated 2-Butenyltert-Butyl Sulfide: A comparison with modelab initio MO calculations

Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins

scientific article

Neospora caninum: in vivo and in vitro treatment with artemisone

scientific article published on 26 December 2011

Neurotoxic mode of action of artemisinin

scientific article published on March 2002

Novel formation of isomeric bicyclo[3.2.0]heptan-1-ols from phenyl vinyl sulfoxide and the cyclopentanone lithium enolate generated by conjugate addition of lithiated (E)-but-2-enyldiphenylphosphine oxide to 2-methylcyclopent-2-enone

article

Photoinduced reactions of 3β-acetoxycholesta-5,7-diene, 3β-acetoxycholest-5-ene, tetraphenylcyclopentadiene and 1,1-diphenylethylene with oxygen in the presence of phenylselenenyl bromide

Possible modes of action of the artemisinin-type compounds.

scientific article

Preliminary Evaluation of Artemisinin-Cholesterol Conjugates as Potential Drugs for the Treatment of Intractable Forms of Malaria and Tuberculosis

scientific article published on 28 November 2017

Preparation of N-sulfonyl- and N-carbonyl-11-azaartemisinins with greatly enhanced thermal stabilities: in vitro antimalarial activities.

scientific article published on October 2007

Preparation of bi- and tridentate doubly P-chiral diphosphine dioxide ligands for asymmetric catalysis

Preparation of bicyclic compounds from the products of conjugate addition of allylic sulphoxide and phosphine oxide carbanions to cyclopent-2-enones

article

Preparation of hydrindenones from 2-methylcyclopent-2-enone and the carbanion of (E)-but-2-enyldiphenylphosphine oxide: efficient enolate trapping with β-sulphonylvinyl ketones

Preparation of stable, camphor-derived, optically active allyl and alkyl sulfoxides and thermal epimerization of the allyl sulfoxides

article published in 1988

Preparation of stable, camphor-derived, optically active allylic sulfoxides

Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance

scientific article published on 17 April 2006

Reactions of (RP)- and (SP)-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with heteroatom nucleophiles; preparation of P-chiral binol phosphinates and related compounds

Reactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified

scientific article

Recent progress in the development of anti-malarial quinolones

scientific article

Reply to Comments on ?Highly Antimalaria-Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity?

Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model

scientific article published on 17 February 2016

Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of action

Simultaneous determination of artemether and its major metabolite dihydroartemisinin in plasma by gas chromatography–mass spectrometry-selected ion monitoring

scientific article published on 01 August 1999

Stereoselective Preparation of 10α- and 10β-Aryl Derivatives of Dihydroartemisinin

Stereoselective preparation of functionalized tertiary P-chiral phosphine oxides by nucleophilic addition of lithiated tert-butylphenylphosphine oxide to carbonyl compounds

article

Straightforward conversion of decoquinate into inexpensive tractable new derivatives with significant antimalarial activities

scientific article published on 9 May 2016

Synthesis of Cyclic Hexapeptides Based on the Antibiotic Cyclic Decapeptide Loloatin C by an in situ Indirect Cyclization Method

Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria

scientific article published on 17 October 2011

Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids

scholarly article by Christo de Lange published in October 2018

Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives

scientific article published on 26 December 2017

The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication

scientific article published on 26 June 2018

The Case for Development of 11-Aza-artemisinins for Malaria

scientific article published on 29 July 2015

The Evaluation of Metal Co-ordinating Bis-Thiosemicarbazones as Potential Anti-malarial Agents

scientific article published on 01 January 2019

The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediates

scientific article

The First Examples of Enantiomerically Pure Diphosphane Dioxides—(RP,RP)- and (SP,SP)-1,2-Di-ter-butyl-1,2-diphenyldiphosphane 1,2-Dioxides, and (RP)- and (SP)-1-tert-Butyl-1,2,2-triphenyldiphosphane 1,2-Dioxides

The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)

The behaviour of qinghaosu (artemisinin) in the presence of non-heme iron(II) and (III)

The diastereospecific aprotic conjugate addition reactions of allylic anions-mechanistic aspects

article

The diastereospecific aprotic conjugate addition reactions of carbanions derived from allylic sulfoxides and allylic phosphine oxides

article

The effect of the Pheroid delivery system on the in vitro metabolism and in vivo pharmacokinetics of artemisone

scientific article published on 10 February 2014

The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug

scientific article published on 14 January 2019

The formation of a peracetal and trioxane from an enol ether with copper(II) triflate and oxygen: Unexpected oxygenation of aldol intermediates

The preparation and reactions of dienol ester and dienol ester derivatives of hagemann's ester and its t-butyl analogue

The preparation of (R)- and (S)-(E)-but-2-enyl-t-butylphenylphosphine oxides and their enantiospecific conversion into enantiomeric hydrindenones related to vitamin D

Topical Delivery of Artemisone, Clofazimine and Decoquinate Encapsulated in Vesicles and Their In vitro Efficacy Against Mycobacterium tuberculosis

scientific article published on 02 January 2019

Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.

scientific article

Trimethylsilyl triflate catalysed Diels-Alder reaction of TMS ethers of conjugated dienols with cyclic enones: Evidence for an endo transition state, and first application to synthesis of enantiopure octalins

Tritylation, methoxymethylation, and silylation of allylic hydroperoxides via stannyl peroxide intermediates. Allylic rearrangement of a stannyl peroxide

Use of .beta.-sulfonyl vinyl ketones as equivalents to vinyl ketones in the Robinson annelation. Convergent, highly stereoselective preparation of a hydrindanol related to vitamin D from 2-methylcyclopent-2-enone and lithiated (E)-but-2-enyldiphenylp

Über den Nachweis freier Radikale bei der Autoxidation des Orcins

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