List of works - Norihito Shibata

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

scientific article

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders

scientific article

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

scientific article published on 15 March 2018

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

scientific article published on 12 March 2020

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

scientific article published on 15 September 2016

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

scientific article published on 8 June 2017

Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein

scientific article published on 01 January 2019

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

scientific article published on 11 October 2013

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

scientific article

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)

scientific article published on 26 October 2018

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

scientific article

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

scientific article (publication date: September 2006)

Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.

scientific article published in August 2005

Macrophages, Oxysterols and Atherosclerosis ⬇️

scientific article published on September 11, 2010

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

scientific article published in January 2016

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

scientific article published in Scientific Reports

Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy

scientific article published on 5 December 2017

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy

scientific article

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

scientific article published on 04 April 2019

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

scientific article

Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1.

scientific article

Regulation of macrophage function in inflammation and atherosclerosis

scientific article

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

scientific article

SNIPERs-Hijacking IAP activity to induce protein degradation

scientific article published on 14 January 2019

Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth.

scientific article

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

scientific article published on 2 August 2017

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

scientific article

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

scientific article published on 10 December 2019

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

scientific article published on 14 September 2017

Vitamin E is essential for mouse placentation but not for embryonic development itself

scientific journal article

List of works by Norihito Shibata

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs).

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP.

Macrophages, Oxysterols and Atherosclerosis ⬇️

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy

Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy

Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

Regulation of SR-BI protein levels by phosphorylation of its associated protein, PDZK1.

Regulation of macrophage function in inflammation and atherosclerosis

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.

SNIPERs-Hijacking IAP activity to induce protein degradation

Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth.

Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide.

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.

Vitamin E is essential for mouse placentation but not for embryonic development itself