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List of works by John T. Harty

A "memorable" NK cell discovery.

scientific article published in March 2009

A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

scientific article published on 10 November 2017

A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation.

scientific article published on 27 July 2009

A knockout approach to understanding CD8+ cell effector mechanisms in adaptive immunity to Listeria monocytogenes

scientific article

A role for IFN-gamma from antigen-specific CD8+ T cells in protective immunity to Listeria monocytogenes

scientific article published in August 2007

Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor.

scientific article

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination.

scientific article published on 12 June 2005

Adaptable TCR avidity thresholds for negative selection.

scientific article

Adaptive immunity against Listeria monocytogenes in the absence of type I tumor necrosis factor receptor p55

scientific article

Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.

scientific article published on 18 September 2013

Antibody response of mice to lactate dehydrogenase-elevating virus during infection and immunization with inactivated virus.

scientific article published in September 1986

Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections

scientific article published on 27 January 2017

Antigen experience shapes phenotype and function of memory Th1 cells

scientific article

Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells

scientific article published on 20 June 2019

C58 and AKR mice of all ages develop motor neuron disease after lactate dehydrogenase-elevating virus infection but only if antiviral immune responses are blocked by chemical or genetic means or as a result of old age.

scientific article published in September 1995

CD8 T cell immunity to Plasmodium permits generation of protective antibodies after repeated sporozoite challenge.

scientific article published on 25 August 2009

CD8 T cell independent immunity after single dose infection-treatment-vaccination (ITV) against Plasmodium yoelii

scientific article published on 07 December 2013

CD8 T cell memory development: CD4 T cell help is appreciated

scientific article published on January 2007

CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion ⬇️

scientific article published on December 1, 1992

CD8 T-cell-mediated protection against liver-stage malaria: lessons from a mouse model

scientific article

CD8(+) T-cell homeostasis after infection: setting the 'curve'.

scientific article

CD8(+) T-cell priming against a nonsecreted Listeria monocytogenes antigen is independent of the antimicrobial activities of gamma interferon

scientific article

CD8(+)-T-cell response to secreted and nonsecreted antigens delivered by recombinant Listeria monocytogenes during secondary infection

scientific article

CD8+ T Cell Effector Mechanisms in Resistance to Infection

scientific article

CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections.

scientific article published on 10 December 2016

CD8+ T cell contraction is controlled by early inflammation.

scientific article published on 11 July 2004

CD8+ T cells in intracellular bacterial infections of mice

scientific article published on October 1996

Characteristics of monoclonal antibodies to the lactate dehydrogenase-elevating virus

scientific article

Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates

scientific article published on 10 October 2017

Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity.

scientific article published in February 1998

Constitutive activation of Wnt signaling favors generation of memory CD8 T cells

scientific article published on 21 December 2009

Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection

scientific article published in March 2008

Correction: Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses

scientific article published on 01 August 2016

Correction: Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei

Correlates of protective immunity following whole sporozoite vaccination against malaria

scientific article published on August 2014

Cutting edge: Expression of FcγRIIB tempers memory CD8 T cell function in vivo.

scientific article

Cutting edge: antilisterial activity of CD8+ T cells derived from TNF-deficient and TNF/perforin double-deficient mice

scientific article published on 01 July 2000

Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization

scientific article

Cutting edge: differential self-peptide/MHC requirement for maintaining CD8 T cell function versus homeostatic proliferation.

scientific article published in October 2005

Cutting edge: rapid boosting of cross-reactive memory CD8 T cells broadens the protective capacity of the Flumist vaccine.

scientific article published on 6 March 2013

Deficient Anti-Listerial Immunity in the Absence of Perforin Can Be Restored by Increasing Memory CD8+ T Cell Numbers ⬇️

scientific article published on October 15, 2003

Detection and analysis of antigen-specific CD8+ T cells

scientific article

Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection.

scientific article

Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites.

scientific article

Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity

scientific article published on 12 June 2017

Differential role of "Signal 3" inflammatory cytokines in regulating CD8 T cell expansion and differentiation in vivo.

scientific article published on 11 February 2011

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1

scientific article

Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes.

scientific article published in May 2009

Discriminating Protective from Nonprotective Plasmodium-Specific CD8+ T Cell Responses

scientific article published on 15 April 2016

Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross

scientific article published on 01 April 2020

Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.

scientific article published on 2 April 2012

Dual virus etiology of age-dependent poliomyelitis of mice. A potential model for human motor neuron diseases.

scientific article published on June 1989

Duration of infection and antigen display have minimal influence on the kinetics of the CD4+ T cell response to Listeria monocytogenes infection.

scientific article

Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T cells responding to infection

scientific article

Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity

scientific article published on 6 January 2017

Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.

scientific article

Enzymatic synthesis of core 2 O-glycans governs the tissue-trafficking potential of memory CD8+ T cells

scientific article

Epitope specificity of memory CD8+ T cells dictates vaccination-induced mortality in LCMV-infected perforin-deficient mice

scientific article published on June 2012

Exploiting cross-priming to generate protective CD8 T-cell immunity rapidly

scientific article

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.

scientific article

Extensive cytocidal replication of lactate dehydrogenase-elevating virus in cultured peritoneal macrophages from 1-2-week-old mice

scientific article published on December 1989

Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.

scientific article

Generation and maintenance of Listeria-specific CD8+ T cell responses in perforin-deficient mice chronically infected with LCMV

scientific article

High initial frequency of TCR-transgenic CD8 T cells alters inflammation and pathogen clearance without affecting memory T cell function.

scientific article published on 5 February 2009

IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo

scientific article published on 23 December 2013

IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking

scientific journal article

Identification of Listeria monocytogenes in vivo-induced genes by fluorescence-activated cell sorting

scientific article

Immunologic considerations for generating memory CD8 T cells through vaccination.

scientific article published on 28 April 2011

Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells.

scientific article published on 19 June 2014

Impact of acute malaria on pre-existing antibodies to viral and vaccine antigens in mice and humans

scientific article published on 28 April 2015

Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice

scientific journal article

In vitro and in vivo macrophage function can occur independently of SLP-76

scientific article published on 01 June 2000

In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice

scientific article (publication date: 2013)

In vivo generation of pathogen-specific Th1 cells in the absence of the IFN-gamma receptor.

scientific article published in September 2005

Inflaming the CD8+ T cell response.

scientific article published on July 2006

Inflammatory IL-15 is required for optimal memory T cell responses

scientific article

Influence of effector molecules on the CD8(+) T cell response to infection

scientific article

Influenza-induced lung Trm: not all memories last forever.

scientific article published on 13 April 2017

Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.

scientific article

Instructing the instructor: tissue-resident T cells activate innate immunity.

scientific article published on October 2014

Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection

scientific article published on 17 February 2009

Intracellular staining for TNF and IFN-gamma detects different frequencies of antigen-specific CD8(+) T cells

scientific article published on 01 April 2000

Isolation of replication-competent molecular clones of visna virus.

scientific article published on March 1991

Listeria monocytogenes infection overcomes the requirement for CD40 ligand in exogenous antigen presentation to CD8(+) T cells.

scientific article

Listeriolysin O-deficient Listeria monocytogenes as a vaccine delivery vehicle: antigen-specific CD8 T cell priming and protective immunity.

scientific article published in September 2006

Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus

scientific article

MHC class Ia-restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)-restricted memory response.

scientific article published on 25 January 2004

Manipulating Memory CD8 T Cell Numbers by Timed Enhancement of IL-2 Signals

scientific article published on 20 July 2016

Manipulating the rate of memory CD8+ T cell generation after acute infection.

scientific article published in July 2007

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

scholarly article

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.

scientific article published on 2 January 2018

Memory lanes

scientific article published on 01 March 2003

Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers

scientific article published on 16 January 2014

Mode of neutralization of lactate dehydrogenase-elevating virus by polyclonal and monoclonal antibodies

scientific article published in January 1992

Modulating numbers and phenotype of CD8+ T cells in secondary immune responses

scientific article

Modulation of hepatocyte protein synthesis by endotoxin-activated Kupffer cells. III. Evidence for the role of a monokine similar to but not identical with interleukin-1.

scientific article published in April 1985

Modulation of hepatocyte protein synthesis during co-cultivation with macrophage-rich peritoneal cells in vitro

scientific article published on 01 February 1985

Monocyte-Derived CD11c+ Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria

scientific article published on 21 March 2019

NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development

scientific article

Naive, effector and memory CD8 T-cell trafficking: parallels and distinctions

scientific article published on October 2011

Neutrophil involvement in cross-priming CD8+ T cell responses to bacterial antigens

scientific article published on 01 August 2004

One bug or another: promiscuous T cells form lifelong memory.

scientific article published in February 2013

Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin

scientific article published on July 2015

Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8(+) T cells by enhancing T cell receptor signaling

scientific article published on 20 December 2012

Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria.

scientific article published on 6 March 2017

Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection.

scientific article

Peripherally induced brain tissue-resident memory CD8+ T cells mediate protection against CNS infection

scientific article published on 22 June 2020

Persistent infection of mice by lactate dehydrogenase-elevating virus: effects of immunosuppression on virus replication and antiviral immune responses

scientific article

Persistent infection of mice by lactate dehydrogenase-elevating virus: transient virus replication in macrophages of the spleen

scientific article published in December 1989

Phenotypic and Functional Alterations in Circulating Memory CD8 T Cells with Time after Primary Infection.

scientific article published on 20 October 2015

Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity

scientific article

Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge

scientific article published on 6 February 2008

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

scientific article published on 14 September 2017

Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo

scientific article published on 28 December 2011

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes ⬇️

scientific article published on October 31, 1991

Predicting CD62L expression during the CD8+ T-cell response in vivo

scientific article

Primary and secondary immune responses to Listeria monocytogenes

scientific article published on August 1996

Probing CD8 T cell responses with Listeria monocytogenes infection.

scientific article published on January 2012

Programmed contraction of CD8(+) T cells after infection

scientific article published on 3 June 2002

Programming, demarcating, and manipulating CD8+ T-cell memory.

scientific article published on June 2006

Protection of C58 mice from lactate dehydrogenase-elevating virus-induced motor neuron disease by non-neutralizing antiviral antibodies without interference with virus replication

scientific article

Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.

scientific article published on July 2009

Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection

scientific article

Protective role for the N-terminal domain of α-dystroglycan in Influenza A virus proliferation.

scientific article

Quantitation of CD8+ T cell expansion, memory, and protective immunity after immunization with peptide-coated dendritic cells.

scientific article published in November 2002

Regulation of CD8+ T cells undergoing primary and secondary responses to infection in the same host

scientific article published in May 2003

Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.

scientific article

Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis

scientific article

Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.

scientific article published on 11 September 2017

Regulatory issues in immunity to liver and blood-stage malaria

scientific article published on 25 June 2016

Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8 T Cells and Heterosubtypic Immunity

article published in 2018

Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation

scientific article

Responses of CD8(+) T cells to intracellular bacteria

scientific article

Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice.

scientific article published on 22 November 2017

Secondary CD8+ T-cell responses are controlled by systemic inflammation

scientific article published on 21 March 2011

Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.

scientific article

Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity

scientific article published on 12 June 2019

Shaping and reshaping CD8+ T-cell memory.

scientific article published on February 2008

Simultaneous assessment of antigen-stimulated cytokine production and memory subset composition of memory CD8 T cells.

scientific article published on 26 May 2006

Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei

scientific article published on March 2008

Specific immunity to Listeria monocytogenes in the absence of IFN gamma

scientific article published on 01 July 1995

Splenectomy Alters Distribution and Turnover but not Numbers or Protective Capacity of de novo Generated Memory CD8 T-Cells

scientific article

Strategies and implications for prime-boost vaccination to generate memory CD8 T cells.

scientific article published on January 2011

Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites

scientific article

Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen.

scientific article

T cell conditioning explains early disappearance of the memory CD8 T cell response to infection

scientific article published in September 2006

T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts.

scientific article

T cell-mediated immunity to malaria

scientific article published on 01 July 2019

T cells undergo rapid ON/OFF but not ON/OFF/ON cycling of cytokine production in response to antigen.

scientific article

TCR beta chain that forms peptide-independent alloreactive TCR transfers reduced reactivity with irrelevant peptide/MHC complex

scientific article published on May 2007

TRAIL deficiency delays, but does not prevent, erosion in the quality of "helpless" memory CD8 T cells

scientific article published on 01 July 2006

Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function

scientific article published on 21 April 2008

The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses

scientific article published on January 2015

The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses.

scientific article published on 2 October 2015

The generation and modulation of antigen-specific memory CD8 T cell responses.

scientific article

The impact of pre-existing memory on differentiation of newly recruited naive CD8 T cells

scientific article

The onset of CD8+-T-cell contraction is influenced by the peak of Listeria monocytogenes infection and antigen display

scientific article

The relevance of non-human primate and rodent malaria models for humans

scientific article

The role of inflammation in the generation and maintenance of memory T cells

scientific article published in January 2010

The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.

scientific article published on 12 June 2017

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

scientific article

Therapeutic intervention in relapsing autoimmune demyelinating disease through induction of myelin-specific regulatory CD8 T cell responses

scientific article published on 01 December 2019

Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection

scientific journal article

Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice

scientific article published on 24 June 2009

Tracking the total CD8 T cell response following whole Plasmodium vaccination.

scientific article published in January 2013

Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts

scientific article

Transient expression of bacterial gene fragments in eukaryotic cells: implications for CD8(+) T cell epitope analysis

scientific article

Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

scientific article published on 01 April 2003

Viral vector vaccines make memory T cells against malaria.

scientific article published on June 2007

Whole parasite vaccination approaches for prevention of malaria infection

scientific article published on 07 March 2012

Worry and FRET: ROS Production Leads to Fluorochrome Tandem Degradation and impairs Interpretation of Flow Cytometric Results

scientific article published on 01 March 2020

You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria

scientific article published on 13 December 2019

p53 Hinders CRISPR/Cas9-Mediated Targeted Gene Disruption in Memory CD8 T Cells In Vivo

scientific article published on 04 September 2020

γδ T cells and immunity to human malaria in endemic regions

scientific article published on May 2015

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