List of works - Anna M. Wu

124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice

scientific article

18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice

scientific article published on 19 November 2018

A Cetuximab-Mediated Suicide System in Chimeric Antigen Receptor-Modified Hematopoietic Stem Cells for Cancer Therapy

scientific article published on 01 April 2019

A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging

scientific article published on 15 March 2019

A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer

scientific article published on December 2003

A fully human scFv phage display library for rapid antibody fragment reformatting

scientific article published on 19 May 2015

A mutated anti-CA19-9 scFv-Fc for positron emission tomography of human pancreatic cancer xenografts

scientific article

A mutation distal to the messenger RNA endpoint reduces transcription termination in the tryptophan operon in Escherichia coli ⬇️

scientific article published on September 5, 1979

A phase I radioimmunotherapy trial evaluating 90yttrium-labeled anti-carcinoembryonic antigen (CEA) chimeric T84.66 in patients with metastatic CEA-producing malignancies.

scientific article

A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies

scientific article

A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer

scientific article

A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments.

scientific article published in June 2006

Advances in immuno-positron emission tomography: antibodies for molecular imaging in oncology

scientific article

Aligning physics and physiology: Engineering antibodies for radionuclide delivery.

scientific article published on 14 March 2018

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy

scientific article

An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors

scientific article published on April 2010

An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles

scientific article published on 19 June 2013

An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors

scientific article published on June 2012

Anti-CA19-9 Diabody as a PET Imaging Probe for Pancreas Cancer ⬇️

scientific article published on April 20, 2011

Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments

scientific article

Antibodies for molecular imaging of cancer

scientific article published on May 2008

Antibody vectors for imaging

scientific article published on May 2010

Applications of immunoPET: using 124I-anti-PSCA A11 minibody for imaging disease progression and response to therapy in mouse xenograft models of prostate cancer

scientific article

Biodistribution and radioimmunotherapy of human breast cancer xenografts with radiometal-labeled DOTA conjugated anti-HER2/neu antibody 4D5.

scientific article

CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer

scientific article

CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy

scientific article published on January 1998

CD8 T-Cell Density Imaging with Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols

scientific article published on 02 July 2018

Characterization of a double-sided silicon strip detector autoradiography system

scientific article

Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT

scientific article

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting

scientific article published on April 2004

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer.

scientific article published on 16 October 2017

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

scientific article

Current and Future Imaging Methods for Evaluating Response to Immunotherapy in Neuro-Oncology

scientific article published on 09 July 2019

Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients.

scientific article

Dual transcript and protein quantification in a massive single cell array

scientific article published on 22 August 2016

Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody

scientific article published on 30 March 2018

Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody

scientific article published on 12 November 2018

Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy

scientific article published in January 2003

Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo

scientific article published on 03 January 2014

Engineered antibody fragments with infinite affinity as reporter genes for PET imaging

scientific article published on 16 October 2008

Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors

scientific article published on 28 October 2008

Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor

scientific article

Enhanced immunoPET of ALCAM-positive colorectal carcinoma using site-specific ⁶⁴Cu-DOTA conjugation

scientific article

Evaluation of [131I]I- and [177Lu]Lu-DTPA-A11 Minibody for Radioimmunotherapy in a Preclinical Model of PSCA-Expressing Prostate Cancer

scientific article published on 13 July 2020

Fluorescent Image-Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time

scientific article

Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging

scientific article

Homologous pairing and topological linkage of DNA molecules by combined action of E. coli recA protein and topoisomerase I ⬇️

scientific article published on 01 April 1981

Human T lymphocyte genetic modification with naked DNA.

scientific article published on January 2000

Humanization of the anti-CEA T84.66 antibody based on crystal structure data

scientific article

Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors

scientific article

Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64-labeled daratumumab

scientific article published on 01 October 2020

Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies

scientific article published on 7 May 2015

ImmunoPET Imaging of Murine CD4+ T Cells Using Anti-CD4 Cys-Diabody: Effects of Protein Dose on T Cell Function and Imaging

scientific article published on 13 December 2016

ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies).

scientific article

ImmunoPET in inflammatory bowel disease: Imaging CD4+ T cells in a murine model of colitis

scientific article published on 11 January 2018

ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo ⬇️

scientific article

ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging

scientific article

Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody

scientific article published on January 2006

Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging

scientific article

In Vivo Eradication of a Rituximab-Resistant Human CD20+ B Cell Lymphoma by Rituximab-CpG Oligodeoxynucleotide Conjugate Is Mediated by Natural Killer Cells and Complement. ⬇️

scholarly article

Initial clinical experience evaluating Yttrium-90-chimeric T84.66 anticarcinoembryonic antigen antibody and autologous hematopoietic stem cell support in patients with carcinoembryonic antigen-producing metastatic breast cancer.

scientific article

Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7

scientific article

Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications

scientific article published in July 2001

Microfluidic-Based 18F-Labeling of Biomolecules for Immuno–Positron Emission Tomography ⬇️

scientific article published on June 1, 2011

Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity ⬇️

scientific article published on February 1, 2010

Minibody-indocyanine green based activatable optical imaging probes: the role of short polyethylene glycol linkers

scientific article

Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts

scientific article

Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange

scientific article

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression.

scientific article published on 27 November 2017

Near-infrared-dye labeled anti-Prostate Stem Cell Antigen minibody enables real-time fluorescence imaging and targeted surgery in translational mouse models

scientific article published on 09 October 2018

Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies

scientific article

Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives

scientific article

Numerical comparison of iodine-based and indium-based antibody biodistributions

scientific article published on 20 January 2014

Numerical selection of optimal tumor imaging agents with application to engineered antibodies

scientific article published in February 2001

Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice

scientific article published on March 2003

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging

scientific article

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

scientific article published on 31 January 2020

Phase I Study of Yttrium-90 Radiolabeled M5A Anti-Carcinoembryonic Antigen Humanized Antibody in Patients with Advanced Carcinoembryonic Antigen Producing Malignancies

scientific article published on 07 January 2020

Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies?

scientific article published on 11 December 2014

Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer

scientific article published in August 2004

Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments

scientific article published on February 2013

Protein Targeting Constructs in Alpha Therapy ⬇️

scientific article published on July 1, 2011

Quantitative immunoPET of prostate cancer xenografts with 89Zr- and 124I-labeled anti-PSCA A11 minibody

scientific article

Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy

scientific article published on January 2007

Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas

scientific article

Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2

scientific article published on December 2008

Tailoring antibodies for radionuclide delivery

scientific article

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

scientific article

Tandem termination sites in the tryptophan operon of Escherichia coli ⬇️

scientific article published on May 1, 1981

Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors

scientific article published on 11 February 2020

Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment

scientific article published on 7 November 2011

Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody

scientific article published on May 2007

The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility

scientific article (publication date: 14 February 2003)

Transcription termination: Nucleotide sequence at 3′ end of tryptophan operon in Escherichia coli ⬇️

scientific article published on November 1, 1978

Tri-functional platform for construction of modular antibody fragments for F-PET or NIRF molecular imaging

Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers ⬇️

scientific article published on February 1, 1996

Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments

scientific article published on March 2001

Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment

scientific article published in January 2006

Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins ⬇️

scientific article published on August 28, 2010

[89Zr]A2cDb Immuno-PET of Prostate Cancer in a Human Prostate Stem Cell Antigen Knock-in (hPSCA KI) Syngeneic Model

scientific article published on 01 April 2020

List of works by Anna M. Wu

124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice

18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice

A Cetuximab-Mediated Suicide System in Chimeric Antigen Receptor-Modified Hematopoietic Stem Cells for Cancer Therapy

A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging

A Phase I trial of 90Y-anti-carcinoembryonic antigen chimeric T84.66 radioimmunotherapy with 5-fluorouracil in patients with metastatic colorectal cancer

A fully human scFv phage display library for rapid antibody fragment reformatting

A mutated anti-CA19-9 scFv-Fc for positron emission tomography of human pancreatic cancer xenografts

A mutation distal to the messenger RNA endpoint reduces transcription termination in the tryptophan operon in Escherichia coli ⬇️

A phase I radioimmunotherapy trial evaluating 90yttrium-labeled anti-carcinoembryonic antigen (CEA) chimeric T84.66 in patients with metastatic CEA-producing malignancies.

A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies

A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer

A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments.

Advances in immuno-positron emission tomography: antibodies for molecular imaging in oncology

Aligning physics and physiology: Engineering antibodies for radionuclide delivery.

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy

An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors

An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticles

An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors

Anti-CA19-9 Diabody as a PET Imaging Probe for Pancreas Cancer ⬇️

Anti-MET immunoPET for non-small cell lung cancer using novel fully human antibody fragments

Antibodies for molecular imaging of cancer

Antibody vectors for imaging

Applications of immunoPET: using 124I-anti-PSCA A11 minibody for imaging disease progression and response to therapy in mouse xenograft models of prostate cancer

Biodistribution and radioimmunotherapy of human breast cancer xenografts with radiometal-labeled DOTA conjugated anti-HER2/neu antibody 4D5.

CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer

CD20 is a molecular target for scFvFc:zeta receptor redirected T cells: implications for cellular immunotherapy of CD20+ malignancy

CD8 T-Cell Density Imaging with Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols

Characterization of a double-sided silicon strip detector autoradiography system

Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT

Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer.

Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

Current and Future Imaging Methods for Evaluating Response to Immunotherapy in Neuro-Oncology

Dose escalation trial of indium-111-labeled anti-carcinoembryonic antigen chimeric monoclonal antibody (chimeric T84.66) in presurgical colorectal cancer patients.

Dual transcript and protein quantification in a massive single cell array

Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody

Dual-Modality ImmunoPET/Fluorescence Imaging of Prostate Cancer with an Anti-PSCA Cys-Minibody

Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy

Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo

Engineered antibody fragments with infinite affinity as reporter genes for PET imaging

Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors

Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor

Enhanced immunoPET of ALCAM-positive colorectal carcinoma using site-specific ⁶⁴Cu-DOTA conjugation

Evaluation of [131I]I- and [177Lu]Lu-DTPA-A11 Minibody for Radioimmunotherapy in a Preclinical Model of PSCA-Expressing Prostate Cancer

Fluorescent Image-Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time

Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging

Homologous pairing and topological linkage of DNA molecules by combined action of E. coli recA protein and topoisomerase I ⬇️

Human T lymphocyte genetic modification with naked DNA.

Humanization of the anti-CEA T84.66 antibody based on crystal structure data

Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors

Identifying CD38+ cells in patients with multiple myeloma: first-in-human imaging using copper-64-labeled daratumumab

Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies

ImmunoPET Imaging of Murine CD4+ T Cells Using Anti-CD4 Cys-Diabody: Effects of Protein Dose on T Cell Function and Imaging

ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies).

ImmunoPET in inflammatory bowel disease: Imaging CD4+ T cells in a murine model of colitis

ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo ⬇️

ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging

Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody

Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging

In Vivo Eradication of a Rituximab-Resistant Human CD20+ B Cell Lymphoma by Rituximab-CpG Oligodeoxynucleotide Conjugate Is Mediated by Natural Killer Cells and Complement. ⬇️

Initial clinical experience evaluating Yttrium-90-chimeric T84.66 anticarcinoembryonic antigen antibody and autologous hematopoietic stem cell support in patients with carcinoembryonic antigen-producing metastatic breast cancer.

Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7

Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications

Microfluidic-Based 18F-Labeling of Biomolecules for Immuno–Positron Emission Tomography ⬇️

Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity ⬇️

Minibody-indocyanine green based activatable optical imaging probes: the role of short polyethylene glycol linkers

Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts

Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression.

Near-infrared-dye labeled anti-Prostate Stem Cell Antigen minibody enables real-time fluorescence imaging and targeted surgery in translational mouse models

Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies

Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives

Numerical comparison of iodine-based and indium-based antibody biodistributions

Numerical selection of optimal tumor imaging agents with application to engineered antibodies

Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice

Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

Phase I Study of Yttrium-90 Radiolabeled M5A Anti-Carcinoembryonic Antigen Humanized Antibody in Patients with Advanced Carcinoembryonic Antigen Producing Malignancies

Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies?