List of works - Ligong Liu

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

scientific article published on 01 December 2019

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.

scientific article

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus

scientific article

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

scientific article

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

scientific article published on 26 September 2016

A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds.

scientific article

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

scientific article published on 01 July 2020

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

scientific article published on 30 March 2012

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

scientific article published on 25 October 2011

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

scientific article

Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries.

scientific article published in May 2004

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

scientific article published on 17 December 2015

Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.

scientific article

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

scientific article

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

scientific article

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

scientific article

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. ⬇️

scientific article published on 6 February 2017

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

scientific article published on 21 September 2020

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

scientific article published on 10 June 2015

Glucuronic acid as a helix-inducing linker in short peptides.

scientific article published on 12 February 2018

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

scientific article published on 19 August 2016

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

scientific article published on 22 June 2015

Inhibitors selective for HDAC6 in enzymes and cells ⬇️

scientific article published on October 12, 2010

Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1.

scientific article

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

article

MAIT cells protect against pulmonary Legionella longbeachae infection ⬇️

scientific article published in Nature Communications

MR1 presents microbial vitamin B metabolites to MAIT cells

scientific article

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

scientific article published on 24 November 2015

Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties

scientific article

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

scientific article

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

scientific article published on 4 May 2016

PAR2 Modulators Derived from GB88.

scientific article

PI-88 and novel heparan sulfate mimetics inhibit angiogenesis.

scientific article published on July 2007

Pathway-selective antagonism of proteinase activated receptor 2.

scientific article

Potent Small Agonists of Protease Activated Receptor 2.

scientific article published on 30 November 2015

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).

scientific article published on 3 March 2016

QSAR Classification Models for Prediction of Hydroxamate Histone Deacetylase Inhibitor Activity against Malaria Parasites

scientific article published on 5 January 2022

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

scientific article

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

scientific article

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

scientific article

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

scientific article published on 7 October 2015

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

scientific article published on 08 March 2017

Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate.

scientific article published on 19 September 2009

Synthesis of disaccharides containing 6-deoxy-α-L-talose as potential heparan sulfate mimetics

scientific article published on 15 August 2012

Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88).

scientific article published in December 2005

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

scientific article

The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

scientific article published on 04 April 2016

The molecular basis underpinning the potency and specificity of MAIT cell antigens

scientific article published on 02 March 2020

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

scientific article published on 7 December 2016

Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding specificity of proteins

scientific article

List of works by Ligong Liu

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.

A highly lipophilic sulfated tetrasaccharide glycoside related to muparfostat (PI-88) exhibits virucidal activity against herpes simplex virus

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds.

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries.

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. ⬇️

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Glucuronic acid as a helix-inducing linker in short peptides.

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

Inhibitors selective for HDAC6 in enzymes and cells ⬇️

Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1.

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

MAIT cells protect against pulmonary Legionella longbeachae infection ⬇️

MR1 presents microbial vitamin B metabolites to MAIT cells

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

PAR2 Modulators Derived from GB88.

PI-88 and novel heparan sulfate mimetics inhibit angiogenesis.

Pathway-selective antagonism of proteinase activated receptor 2.

Potent Small Agonists of Protease Activated Receptor 2.

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).

QSAR Classification Models for Prediction of Hydroxamate Histone Deacetylase Inhibitor Activity against Malaria Parasites

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

Synthesis of a heparan sulfate mimetic disaccharide with a conformationally locked residue from a common intermediate.

Synthesis of disaccharides containing 6-deoxy-α-L-talose as potential heparan sulfate mimetics

Synthesis, biological activity, and preliminary pharmacokinetic evaluation of analogues of a phosphosulfomannan angiogenesis inhibitor (PI-88).

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding specificity of proteins