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List of works by Michael P. Barrett

6-Phosphogluconate Dehydrogenase from Trypanosoma Brucei. Kinetic Analysis and Inhibition by Trypanocidal Drugs

article

6-Phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme.

scientific article published on February 1999

6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species

scientific journal article

6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes

scientific article

A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues

scientific article

A 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei.

scientific article

A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity

scientific article

A comparison of leg length and femoral offset discrepancies in hip resurfacing, large head metal-on- metal and conventional total hip replacement: a case series

scientific article published on 29 December 2011

A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity.

scientific article published in July 1995

A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats

scientific article published in January 2006

A drug resistance determinant in Trypanosoma brucei.

scientific article

A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes

scientific article published on 15 July 2010

A glucose transporter can mediate ribose uptake.: DEFINITION OF RESIDUES THAT CONFER SUBSTRATE SPECIFICITY IN A SUGAR TRANSPORTER.

scientific article published in March 2011

A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter.

scientific article published on 2 July 2010

A large gene family for putative variant antigens shared by human and rodent malaria parasites.

scientific article published in February 2002

A molecular mechanism for eflornithine resistance in African trypanosomes

scientific article

A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase.

scientific article published on 12 November 2007

A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates

scientific article published in May 1997

Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data

scientific article

Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage

scientific article

Affinity chromatography using trypanocidal arsenical drugs identifies a specific interaction between glycerol-3-phosphate dehydrogenase from Trypanosoma brucei and Cymelarsan.

scientific article published in January 1999

African sleeping sickness.

scientific article published on 5 March 2008

An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei

scientific article

An Integrated Circuit for Chip-Based Analysis of Enzyme Kinetics and Metabolite Quantification

scientific article published on 6 January 2016

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

scientific article published on 01 April 1998

Anti-sleeping Sickness Drugs and Cancer Chemotherapy

Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines.

scientific article published on July 2003

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

scientific article

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds

scientific article

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei

scientific article (publication date: July 2014)

Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics

scientific article (publication date: May 2014)

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

scientific article published on 14 May 2018

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool.

scientific article published on 23 February 2015

Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei

scientific article published on 2 June 2008

Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis

scientific article

Characterization of glucose transport and cloning of a hexose transporter gene in Trypanosoma cruzi

scientific article published on August 1994

Chemotherapy of human African trypanosomiasis

scientific article

Chemotherapy of trypanosomiases and leishmaniasis

scientific article

Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata

scientific article published in July 1998

Cloning of the 6-phosphogluconate dehydrogenase gene from Trypanosoma brucei by complementation in Escherichia coli.

scientific article

Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan

scientific article published on 21 April 2003

Counterflow dielectrophoresis for trypanosome enrichment and detection in blood

scientific article

Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster

scientific article

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

scientific article

Crystallization and preliminary X-ray diffraction studies of 6-phosphogluconate dehydrogenase from Lactococcus lactis

article

Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

scientific article published on 29 June 2023

DNA Binding Affinity of Bisguanidine and Bis(2-aminoimidazoline) Derivatives with in Vivo Antitrypanosomal Activity

scientific article published on 01 June 2006

Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana.

scientific article

Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites

scientific article published on August 2005

Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test

scientific article

Determination of antiprotozoal drug mechanisms by metabolomics approaches.

scientific article published on 05 June 2013

Development of novel drugs for human African trypanosomiasis

scientific article published on June 2011

Diamidines for human African trypanosomiasis

scientific article published on August 2010

Drug resistance in human African trypanosomiasis

scientific article published on September 2011

Drug uptake via nutrient transporters in Trypanosoma brucei.

scientific article

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism ⬇️

scientific article published on January 19, 2012

Emerging paradigms in anti-infective drug design

scientific article

Energy generation in insect stages of Trypanosoma brucei: metabolism in flux

scientific article

Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines

scientific article

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis

scientific article

Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine.

scientific article published in February 2012

Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis

scientific article published on 19 August 2013

Exploiting the potential of vector control for disease prevention

scientific article

Functional expression and characterization of the Trypanosoma brucei procyclic glucose transporter, THT2

scientific article published on December 1995

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

scientific article published on 10 February 2013

Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes.

scientific article

Gene discovery in Plasmodium chabaudi by genome survey sequencing

scientific article

Genetic characterization of glucose transporter function in Leishmania mexicana

scholarly article

Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites

scientific article published on 04 February 2019

Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal

scientific article

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei ⬇️

scientific article published on 27 December 2018

Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei

scientific article published on 22 April 2008

Green fluorescent diamidines as diagnostic probes for trypanosomes

scientific article published on 23 December 2013

Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei

scientific article (publication date: 2013)

Hexose uptake in Trypanosoma cruzi: structure-activity relationship between substrate and transporter.

scientific article published on July 1996

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites

scientific article

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

scientific article published on 9 February 2018

Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

scientific article published on 9 July 2007

IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data

scientific article

Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT.

scientific article

In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis

scientific article

Increasing the mass accuracy of high-resolution LC-MS data using background ions: a case study on the LTQ-Orbitrap

scientific article

Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter

scientific article

Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter

scientific article published in February 2004

Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes

scientific article

Kinetoplastid glucose transporters.

scientific article published on August 1997

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis

scientific article published on 31 March 2009

LC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes

scientific article

Life in vacuoles--nutrient acquisition by Leishmania amastigotes.

scientific article

Management of trypanosomiasis and leishmaniasis

scientific article

Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry.

scientific article

McArthur revisited: fluorescence microscopes for field diagnostics

scientific article

Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei

scientific article

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis

scientific article

MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks

scientific article published on 5 May 2010

MetaNetter: inference and visualization of high-resolution metabolomic networks.

scientific article published on 14 November 2007

Metabolite-dependent regulation of gene expression in Trypanosoma brucei.

scientific article

Metabolomic analysis of trypanosomatid protozoa

scientific article published on 19 October 2011

Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules

scientific article published in June 2008

Metabolomic systems biology of trypanosomes

scientific article published on 17 February 2010

Metabolomic-based strategies for anti-parasite drug discovery.

scientific article published on 03 October 2014

Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis

scientific article

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. ⬇️

scientific article published on 09 April 2013

Microfluidics-Based Approaches to the Isolation of African Trypanosomes

scientific article published on 5 October 2017

Minor groove binders as anti-infective agents.

scientific article

Molecular cloning, expression and characterization of ribokinase of Leishmania major.

scientific article published in June 2007

Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes

scientific article

Multiple roles of proline transport and metabolism in trypanosomatids

scientific article published on January 2012

N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift.

scientific article published on 27 March 2008

New surveyor tools for charting microbial metabolic maps.

scientific article published on February 2008

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites

scientific article

Overexpression in Escherichia coli and purification of the 6-phosphogluconate dehydrogenase of Trypanosoma brucei.

scientific article

Paromomycin: uptake and resistance in Leishmania donovani.

scientific article published on 25 December 2008

Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry

scientific article

Pentamidine uptake and resistance in pathogenic protozoa: past, present and future

scientific article

Pentose phosphate metabolism in Leishmania mexicana

scientific article published in August 2003

Perspectives for new drugs against trypanosomiasis and leishmaniasis

scientific article

Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites

scientific article published on 26 October 2004

Polymorphism among alleles of the 6-phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica.

scientific article published on November 2002

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione

scientific article published on 19 December 2014

Potential new drugs for human African trypanosomiasis: some progress at last

scientific article published on December 2010

Precision mapping of the metabolome.

scientific article published on 24 October 2006

Predictive computational models of substrate binding by a nucleoside transporter

scientific article

Preliminary Crystallographic Study of 6-Phosphogluconate Dehydrogenase from Trypanosoma brucei

scientific article published on 01 September 1993

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

scientific article

Problems for the chemotherapy of human African trypanosomiasis.

scientific article published in December 2000

Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline

scientific article published on 01 March 2021

Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose

scientific article published on 21 January 2005

Protozoan persister-like cells and drug treatment failure

scientific article published on 23 August 2019

Putrescine and spermidine transport in Leishmania

scientific article published in June 2000

Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics

scientific article

Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.

scientific article

Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.

scientific article

Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani.

scientific article

Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance

scientific article published on 15 August 2006

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif

scientific article

Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei.

scientific article published in May 2001

Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues

scientific article

Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry

scientific article

Separation of parasites from human blood using deterministic lateral displacement

scientific article

Shape-dependent optoelectronic cell lysis

scientific article published on January 2014

Sleeping sickness and the brain

scientific article

Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation

scientific article published on 25 September 2012

Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks

scientific article

Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

scientific article

Structure and function of facilitative sugar transporters

scientific article

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

scientific article

Sugar transporters from bacteria, parasites and mammals: structure-activity relationships

scientific article

Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles.

scientific article

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

scientific article

Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis

scientific article published on 2 August 2012

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase

scientific article

Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.

scientific article

Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis

scientific article

Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor

scientific article

Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

scientific article published on 14 September 2008

Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles

scientific article published on 26 September 2007

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif

scientific article published on 31 January 2009

Targeting of toxic compounds to the trypanosome's interior

scientific article

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

scientific article published on 13 July 2020

The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii

scientific article published on 11 January 2013

The 6-phosphogluconate dehydrogenase of Leishmania (Leishmania) mexicana: gene characterization and protein structure prediction.

scientific article

The Pentose Phosphate Pathway in Parasitic Trypanosomatids

scientific article published on 9 May 2016

The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.

scientific article published on 30 April 2009

The animal trypanosomiases and their chemotherapy: a review

scientific article

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes

scientific article

The cross-linking by o-phthalaldehyde of two amino acid residues at the active site of 6-phosphogluconate dehydrogenase

scientific article published on 01 September 1997

The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes

scientific article

The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis

scientific article published on 06 December 2018

The fall and rise of sleeping sickness

scientific article published in The Lancet

The natural progression of Gambiense sleeping sickness: what is the evidence?

scientific article

The pentose phosphate pathway and parasitic protozoa

scientific article published in January 1997

The plastidic DNA replication enzyme complex of Plasmodium falciparum

scientific article (publication date: June 2005)

The rise and fall of sleeping sickness

scientific article published in April 2006

The silicon trypanosome.

scientific article published on 06 May 2010

The silicon trypanosome: a test case of iterative model extension in systems biology

scientific article published on January 2014

The structure-function relationship of functionally distinct but structurally similar hexose transporters from Trypanosoma congolense.

scientific article published in August 2000

The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control.

scientific article

The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

scientific article published on May 2004

The trypanosomiases.

scientific article

Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction

scientific article

Transketolase from Leishmania mexicana has a dual subcellular localization

scientific article published on September 2004

Transketolase in Trypanosoma brucei

scientific article published on 12 May 2011

Transport of methionine in Trypanosoma brucei brucei

scientific article published on 01 December 2000

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

scientific article

Trypanocidal activity of melamine-based nitroheterocycles

scientific article published on May 2004

Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns

scientific article

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

scientific article

Trypanosoma brucei: meet the system

scientific article published on 16 July 2014

Trypanosome glucose transporters.

scientific article published on March 1998

Trypanosomiasis and Leishmaniasis: Between the Idea and the Reality of Control

Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains

scientific article published in March 2009

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action.

scientific article published on February 2016

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei ⬇️

scientific article

Uptake and mode of action of drugs used against sleeping sickness.

scientific article

Uptake of the nitroimidazole drug megazol by African trypanosomes

scientific article published in 2000

Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining

scientific article

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

scientific article published on 6 July 2015

Veterinary link to drug resistance in human African trypanosomiasis?

scientific article published in August 2001

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

scientific article published on 03 November 2020

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase.

scientific article

Waking up to sleeping sickness

scientific article

Why aren't we doing more to safeguard vulnerable adults from thermal injuries?

scientific article published on 12 September 2013

mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data

scientific article

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