List of works by Annette MacLeod

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense

scientific article

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome

scientific article published on February 2015

A major genetic locus in Trypanosoma brucei is a determinant of host pathology

scientific article

A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations

scientific article published on 27 October 2017

A protocol to improve genotyping of problematic microsatellite loci of Trypanosoma brucei gambiense from body fluids

scientific article published on 15 August 2013

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

scientific article

Allelic segregation and independent assortment in T. brucei crosses: proof that the genetic system is Mendelian and involves meiosis

scientific article published in September 2005

Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon

article

Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi

scientific article published on 14 August 2019

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

scientific article published on 14 May 2018

Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea

scientific article

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire

scientific article published on 23 October 2017

Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire

article

Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016.

scientific article published on July 2017

Characterization of di-, tri-, and tetranucleotide microsatellite markers with perfect repeats for Trypanosoma brucei and related species

scientific article

Copy number variation in human genomes from three major ethno-linguistic groups in Africa

scientific article published on 10 April 2020

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.

scientific article published on 18 January 2018

Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1

scientific article published in September 2011

Differences in pathogenicity and virulence of Trypanosoma brucei gambiense field isolates in experimentally infected Balb/C mice

scientific article published in 2018

Digital gene expression analysis of two life cycle stages of the human-infective parasite, Trypanosoma brucei gambiense reveals differentially expressed clusters of co-regulated genes

scientific article

Discovery of mating in the major African livestock pathogen Trypanosoma congolense

scientific article

Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?

scientific article published on 19 January 2018

Evidence of population specific selection inferred from 289 genome sequences of Nilo-Saharan and Niger-Congo linguistic groups in Africa

Exploiting genetic variation to discover genes involved in important disease phenotypes

scientific article

Extravascular dermal trypanosomes in suspected and confirmed cases of gambiense Human African Trypanosomiasis

scientific article published on 08 July 2020

First evidence that parasite infecting apparent aparasitemic serological suspects in human African trypanosomiasis are Trypanosoma brucei gambiense and are similar to those found in patients

scientific article published on 17 April 2011

Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits

scientific article

Genetic analysis of the human infective trypanosome Trypanosoma brucei gambiense: chromosomal segregation, crossing over, and the construction of a genetic map

scientific article published on 22 June 2008

Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development.

scientific article published on 15 November 2006

Genome and phylogenetic analyses of trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty

scientific article published in January 2015

Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors

scientific article published on January 2012

High Levels of Genetic Diversity within Nilo-Saharan Populations: Implications for Human Adaptation

scientific article published on 06 August 2020

Human African trypanosomiasis presenting at least 29 years after infection--what can this teach us about the pathogenesis and control of this neglected tropical disease?

scientific article published on 18 December 2014

Human and animal Trypanosomes in Côte d'Ivoire form a single breeding population

scientific article

Introducing the TrypanoGEN biobank: A valuable resource for the elimination of human African trypanosomiasis

scientific article

Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population

scientific article published on 23 March 2019

Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor

scientific article

Multilocus genotyping of Cryptosporidium parvum Type 2: population genetics and sub-structuring

scientific article published on September 2003

No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations.

scientific article published on 22 February 2018

No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

scholarly article published 25 August 2017

Novel African trypanocidal agents: membrane rigidifying peptides

scientific article

Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection

scientific article published on 19 February 2019

Persistently High Incidences of Trypanosoma brucei rhodesiense Sleeping Sickness With Contrasting Focus-Dependent Clinical Phenotypes in Malawi

scientific article published in 2022

Population Genetics and Reproductive Strategies of African Trypanosomes: Revisiting Available Published Data

scientific article

Population genetic structure of Guinea Trypanosoma brucei gambiense isolates according to host factors

scientific article published on 14 April 2011

Population genetics of Trypanosoma brucei gambiense in sleeping sickness patients with treatment failures in the focus of Mbuji-Mayi, Democratic Republic of the Congo

scientific article

Population genetics of Trypanosoma brucei rhodesiense: clonality and diversity within and between foci

scientific article published on 14 November 2013

Population genomics reveals the origin and asexual evolution of human infective trypanosomes

scientific article published on 26 January 2016

Population structures and the role of genetic exchange in the zoonotic pathogen Cryptosporidium parvum

scientific article published on April 2003

Research capacity. Enabling the genomic revolution in Africa

scientific article published in June 2014

Resolving the apparent transmission paradox of African sleeping sickness

article

Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection

scientific article

Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei

scientific article

SNPs in IL4 and IFNG show no protective associations with human African trypanosomiasis in the Democratic Republic of the Congo: a case-control study

scientific article published on 04 August 2020

Spatially and genetically distinct African Trypanosome virulence variants defined by host interferon-gamma response

scientific article

T cell activation and the HLA locus associate with latent infections of human African trypanosomiasis

The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism

scientific article

The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense

scientific article

The genetic map and comparative analysis with the physical map of Trypanosoma brucei

scientific article

The genetic map and comparative analysis with the physical map of Trypanosoma brucei

scientific article (publication date: 30 January 2006)

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis

scientific article

The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides

scientific article

The population structure of the Cryptosporidium parvum population in Scotland: a complex picture

scientific article

The sequence and analysis of Trypanosoma brucei chromosome II.

scientific article

The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

scientific article

To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host

scientific article published on 12 June 2020

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

scientific article

Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation

scientific article published on 23 August 2008

Trypanosoma vivax displays a clonal population structure

scientific article published on 8 June 2009

Trypanosome genetics: populations, phenotypes and diversity

scientific article published on 19 April 2011

Trypanosome resistance to human innate immunity: targeting Achilles' heel

scientific article

Use of multiple displacement amplification to increase the detection and genotyping of trypanosoma species samples immobilized on FTA filters.

scientific article

Whole-genome sequencing of Trypanosoma brucei reveals introgression between subspecies that is associated with virulence

scientific article published on 20 August 2013

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