List of works - Sergio E Baranzini

A framework and mechanistically focused, in silico method for enabling rational translational research ⬇️

scientific article published on March 1, 2008

A genome-wide association study of brain lesion distribution in multiple sclerosis

scientific journal article

A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome

scientific article published on 3 October 2015

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

scientific article published on 28 August 2020

A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFNβ drugs in the treatment of multiple sclerosis

scientific article published on 26 February 2015

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases

scientific article published in November 2015

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation

scientific article published on 15 April 2019

Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

scholarly article

An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges

scientific article published in 2023

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

scientific article published on 29 September 2013

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis

scientific article published on 31 May 2016

Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls

scientific article published on 06 June 2013

Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis

scientific article published on 29 December 2020

Class II HLA interactions modulate genetic risk for multiple sclerosis

scientific article published on 07 September 2015

Deletion patterns in Argentine patients with Duchenne and Becker muscular dystrophy ⬇️

scientific article published on 01 July 1998

Differential micro RNA expression in PBMC from multiple sclerosis patients

scientific article

Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts

scientific article published on June 2003

Dynamic, multi-level network models of clinical trials.

scientific article

Embedding electronic health records onto a knowledge network recognizes prodromal features of multiple sclerosis and predicts diagnosis

scientific article published on 26 November 2021

Expression profiling of Aldh1l1‐precursors in the developing spinal cord reveals glial lineage‐specific genes and direct Sox9‐Nfe2l1 interactions ⬇️

scientific article published on July 10, 2013

Four new polymorphisms in the human dystrophin gene from an Argentinian population ⬇️

scientific article published on November 1, 1997

Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis

scientific article published in July 2002

Gene expression profiling in MS: a fulfilled promise?

scientific article published in December 2013

Gene expression profiling in neurological disorders: toward a systems-level understanding of the brain

scientific article

Genetic contribution to multiple sclerosis risk among Ashkenazi Jews

scientific article published on 28 July 2015

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

scientific article

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

scientific article published on 26 July 2019

Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset

scientific article

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

scientific journal article

Genetics of multiple sclerosis: swimming in an ocean of data

scientific article

Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis

scientific article published on 03 July 2018

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

scientific article

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

scientific journal article

Genome-wide network analysis reveals the global properties of IFN-beta immediate transcriptional effects in humans

scientific article published on April 2007

Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.

scientific article

Genomics and new targets for multiple sclerosis

scientific article

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.

scientific article published on 11 September 2017

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

scientific article published on 11 September 2017

Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis

scientific article published on 01 November 2020

Harnessing electronic medical records to advance research on multiple sclerosis

scientific article published in January 2018

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

scientific article published on 11 August 2006

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors

scientific article published on 17 April 2013

Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis

scientific article published on 22 August 2016

In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing

scientific article

Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis

scientific article published in September 2007

Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings

scientific article published on 10 July 2019

Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

scientific article published in 2021

Large-scale gene-expression studies and the challenge of multiple sclerosis

scientific article

Long-term evolution of multiple sclerosis disability in the treatment era.

scientific article published on 27 July 2016

Low frequency and rare coding variation contributes to multiple sclerosis risk

Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1.

scientific article

Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis

scientific article published on 01 October 2005

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

scientific article

Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS

scientific article published on 19 November 2020

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

scientific article

Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis

scientific article published on 12 March 2016

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

scientific article

Modular transcriptional activity characterizes the initiation and progression of autoimmune encephalomyelitis

scientific article published in June 2005

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

scientific article

Multiple sclerosis genetics--is the glass half full, or half empty?

scientific article published on 13 July 2010

New insights into the genetics of multiple sclerosis.

scientific article

Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis

scientific article

PINBPA: cytoscape app for network analysis of GWAS data

scientific article

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

scientific article published on 13 March 2009

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity

scientific article

Precision medicine in chronic disease management: The multiple sclerosis BioScreen

scientific article

Prognostic biomarkers of IFNb therapy in multiple sclerosis patients

scientific article published on 12 November 2014

Progress toward a universal biomedical data translator

publication published in 2022

Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy

scientific article published in May 2007

Revealing the genetic basis of multiple sclerosis: are we there yet?

scientific article

Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients.

scientific article

SARS-CoV-2 meta-interactome suggests disease-specific, autoimmune pathophysiologies and therapeutic targets

scientific article published on 17 August 2020

Serum antibodies to phosphatidylcholine in MS

scientific article published on 09 June 2020

Silent progression in disease activity-free relapsing multiple sclerosis

scientific article published on 30 March 2019

Symposium 2-1 The autoimmunome: Similarities and differences among genetic susceptibility to common immune-related diseases

scientific article published on January 2014

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

scientific article published on 22 September 2017

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

peer reviewed article

Systems biology and its application to the understanding of neurological diseases.

scientific article published on February 2009

Systems-based medicine approaches to understand and treat complex diseases. The example of multiple sclerosis

scientific article published on December 2006

The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years.

scientific article published on 5 October 2017

The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-β

article

The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease ⬇️

scientific article published on November 23, 2001

The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility

scholarly article published 13 July 2017

The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the "MS Microbiome".

scientific article

The era of GWAS is over - Commentary

scientific article published in December 2017

The genetics of autoimmune diseases: a networked perspective

scientific article

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

scientific article published on 10 June 2008

The genetics of multiple sclerosis: an up-to-date review

scientific article published on July 2012

The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse

scientific article

The role of antiproliferative gene Tob1 in the immune system

scientific article

The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information

scientific article published in February 2023

Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity

scientific article published on July 2013

Transcription-based prediction of response to IFNbeta using supervised computational methods

scientific article

Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules ⬇️

scientific article published on September 15, 2012

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis

scientific article

Vitamin D Regulates MerTK-Dependent Phagocytosis in Human Myeloid Cells

scientific article published on 15 June 2020

Whole genome sequences of 2 octogenarians with sustained cognitive abilities

scientific article

iPINBPA: an integrative network-based functional module discovery tool for genome-wide association studies

scientific article published on January 2015

microRNA and exosome profiling in multiple sclerosis

scientific article published on 22 January 2020

List of works by Sergio E Baranzini

A framework and mechanistically focused, in silico method for enabling rational translational research ⬇️

A genome-wide association study of brain lesion distribution in multiple sclerosis

A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

A robust type I interferon gene signature from blood RNA defines quantitative but not qualitative differences between three major IFNβ drugs in the treatment of multiple sclerosis

A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation

Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event

An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis

Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls

Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis

Class II HLA interactions modulate genetic risk for multiple sclerosis

Deletion patterns in Argentine patients with Duchenne and Becker muscular dystrophy ⬇️

Differential micro RNA expression in PBMC from multiple sclerosis patients

Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts

Dynamic, multi-level network models of clinical trials.

Embedding electronic health records onto a knowledge network recognizes prodromal features of multiple sclerosis and predicts diagnosis

Expression profiling of Aldh1l1‐precursors in the developing spinal cord reveals glial lineage‐specific genes and direct Sox9‐Nfe2l1 interactions ⬇️

Four new polymorphisms in the human dystrophin gene from an Argentinian population ⬇️

Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis

Gene expression profiling in MS: a fulfilled promise?

Gene expression profiling in neurological disorders: toward a systems-level understanding of the brain

Genetic contribution to multiple sclerosis risk among Ashkenazi Jews

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

Genetics of multiple sclerosis: swimming in an ocean of data

Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Genome-wide network analysis reveals the global properties of IFN-beta immediate transcriptional effects in humans

Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.

Genomics and new targets for multiple sclerosis

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis

Harnessing electronic medical records to advance research on multiple sclerosis

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors

Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis

In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing

Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis

Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings

Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

Large-scale gene-expression studies and the challenge of multiple sclerosis

Long-term evolution of multiple sclerosis disability in the treatment era.

Low frequency and rare coding variation contributes to multiple sclerosis risk

Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1.

Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

Modular transcriptional activity characterizes the initiation and progression of autoimmune encephalomyelitis

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

Multiple sclerosis genetics--is the glass half full, or half empty?

New insights into the genetics of multiple sclerosis.

Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis

PINBPA: cytoscape app for network analysis of GWAS data

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity

Precision medicine in chronic disease management: The multiple sclerosis BioScreen

Prognostic biomarkers of IFNb therapy in multiple sclerosis patients

Progress toward a universal biomedical data translator

Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy

Revealing the genetic basis of multiple sclerosis: are we there yet?

Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients.

SARS-CoV-2 meta-interactome suggests disease-specific, autoimmune pathophysiologies and therapeutic targets

Serum antibodies to phosphatidylcholine in MS

Silent progression in disease activity-free relapsing multiple sclerosis

Symposium 2-1 The autoimmunome: Similarities and differences among genetic susceptibility to common immune-related diseases

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

Systematic integration of biomedical knowledge prioritizes drugs for repurposing

Systems biology and its application to the understanding of neurological diseases.

Systems-based medicine approaches to understand and treat complex diseases. The example of multiple sclerosis