Search filters

List of works by Lee Jia

A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells

scientific article

A Flavonoid Glycoside Compound from Murraya paniculata (L.) Interrupts Metastatic Characteristics of A549 Cells by Regulating STAT3/NF-κB/COX-2 and EGFR Signaling Pathways

scientific article published on 25 August 2017

A functionalized dumbbell probe-based cascading exponential amplification DNA machine enables amplified probing of microRNAs

scientific article published on 01 February 2020

A novel S-nitrosocaptopril monohydrate for pulmonary arterial hypertension: H2O and -SNO intermolecular stabilization chemistry

scientific article published on 15 September 2018

A novel SPE-HPLC method for simultaneous determination of selected sulfonated phthalocyanine zinc complexes in mouse plasma following cassette dosing

scientific article published on 06 June 2013

A novel UPLC-MS/MS method for sensitive quantitation of boldine in plasma, a potential anti-inflammatory agent: application to a pharmacokinetic study in rats

scientific article

A novel UPLC/MS/MS method for rapid determination of metapristone in rat plasma, a new cancer metastasis chemopreventive agent derived from mifepristone (RU486).

scientific article published on 12 March 2014

A novel UPLC/MS/MS method for rapid determination of murrayone in rat plasma and its pharmacokinetics

scientific article published on 16 December 2019

A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment

scientific article published on 24 September 2016

A novel nanomissile targeting two biomarkers and accurately bombing CTCs with doxorubicin.

scientific article published on 19 April 2017

A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis.

scientific article published in April 2015

A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.

scientific article

AIDS treatment with novel anti-HIV compounds improved by nanotechnology

scientific article published on 6 April 2010

Abortifacient metapristone (RU486 derivative) interrupts CXCL12/CXCR4 axis for ovarian metastatic chemoprevention.

scientific article published on 9 March 2017

Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT

scientific article published on 31 August 2020

Acute and subacute toxicity and efficacy of S-nitrosylated captopril, an ACE inhibitor possessing nitric oxide activities ⬇️

scientific article published on December 1, 2001

Antiangiogenic effects of S-nitrosocaptopril crystals as a nitric oxide donor

scientific article published on 01 March 2000

Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

scientific article published on July 2006

Aptamer-Conjugated Chitosan-Anchored Liposomal Complexes for Targeted Delivery of Erlotinib to EGFR-Mutated Lung Cancer Cells.

scientific article published on 23 February 2017

Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil

scientific article published on 8 October 2015

Author Correction: Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT

scientific article published on 13 October 2020

Autonomous assembly of ordered metastable DNA nanoarchitecture and in situ visualizing of intracellular microRNAs.

scientific article

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

scientific article

Bioactivity-guided fast screen and identification of cancer metastasis chemopreventive components from raw extracts of Murraya exotica.

scientific article

Biomedical activities of endohedral metallofullerene optimized for nanopharmaceutics.

scientific article

Biostability and pharmacokinetics of LJP 920, an octameric Gal (alpha1-3) Gal conjugate for the inhibition of xenotransplantation rejection.

scientific article published in July 2001

Blood Flow Regulation by S-Nitrosohemoglobin in the Physiological Oxygen Gradient

scientific article published in Science

CXCR7 is not obligatory for CXCL12-CXCR4-induced epithelial-mesenchymal transition in human ovarian cancer

scientific article published on 16 October 2018

Carbendazim: disposition, cellular permeability, metabolite identification, and pharmacokinetic comparison with its nanoparticle.

scientific article published on January 2003

Cascade DNA nanomachine and exponential amplification biosensing.

scientific article published on 23 May 2015

China and the United States--Global partners, competitors and collaborators in nanotechnology development.

scientific article published on 28 September 2015

Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer.

scientific article

Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib.

scientific article published on 31 May 2019

Collapse of chain anadiplosis-structured DNA nanowires for highly sensitive colorimetric assay of nucleic acids.

scientific article published on 25 January 2017

Comparisons between Graphene Oxide and Graphdiyne Oxide in Physicochemistry Biology and Cytotoxicity

scientific article published on 21 September 2018

Correction: A novel nanomissile targeting two biomarkers and accurately bombing CTCs with doxorubicin

scientific article published on 01 May 2018

Corrigendum to 'Metapristone suppresses non-small cell lung cancer proliferation and metastasis via modulating RAS/RAF/MEK/MAPK signaling pathway' [Biomed. Pharmacother. 90 (2017) 437-445].

scientific article published in February 2018

Corrigendum to ‘Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells’ [Cancer letters, 2013, 330(1): 49–56]

scientific article published on 15 March 2018

Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine.

scientific article published on January 2009

Current evaluation of the millennium phytomedicine--ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations

scientific article published on January 2009

Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: synthesis and biological evaluation.

scientific article

Double-stem Hairpin Probe and Ultrasensitive Colorimetric Detection of Cancer-related Nucleic Acids

scientific article published on January 2016

Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics.

scientific article published on December 2013

Dual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells

scientific article published on 14 March 2019

Dual-cyclical nucleic acid strand-displacement polymerization based signal amplification system for highly sensitive determination of p53 gene.

scientific article published on 9 July 2016

Effect of nanonization on absorption of 301029: ex vivo and in vivo pharmacokinetic correlations determined by liquid chromatography/mass spectrometry

scientific article

Effect of nitric oxide on cytotoxicity of Taxol: enhanced Taxol transcellular permeability.

scientific article published on December 2003

Effects of cyclosporine A and itraconazole on permeability, biliary excretion and pharmacokinetics of amlodipine.

scientific article

EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

scientific article published on 09 December 2015

Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis

scientific article published on 4 October 2011

Erlotinib-guided self-assembled trifunctional click nanotheranostics for distinguishing druggable mutations and synergistic therapy of NSCLC

scientific article published on 18 October 2018

Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials

scientific article published on 28 April 2015

Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial

scientific article

Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT

scientific article published on 01 May 2019

Fluorescent Se-modified carbon nitride nanosheets as biomimetic catalases for free-radical scavenging

scientific article published on 18 December 2019

Functionalized MoS2-erlotinib produces hyperthermia under NIR.

scientific article published on 19 June 2019

Global deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interaction

scientific article

HAMPT, A Novel Quadruple Drug Combination Designed for Cancer Metastatic Chemoprevention: From Hypothesis to Proof-of-concept

scientific article published on 01 January 2019

Immunomagnetic antibody plus aptamer pseudo-DNA nanocatenane followed by rolling circle amplication for highly-sensitive CTC detection

scientific article published on 07 September 2018

Immunomodulatory effects of Pseudostellaria heterophylla peptide on spleen lymphocytes via a Ca2+/CaN/NFATc1/IFN-γ pathway

scientific article published on 01 June 2019

Impacts of Nanoparticles on Cardiovascular Diseases: Modulating Metabolism and Function of Endothelial Cells ⬇️

scientific article published on October 1, 2012

In vitro and in vivo assessment of cellular permeability and pharmacodynamics of S‐nitrosylated Captopril, a nitric oxide donor ⬇️

scientific article published on December 1, 2001

In vitro and in vivo efficacy and safety evaluation of metapristone and mifepristone as cancer metastatic chemopreventive agents.

scientific article published on 04 February 2016

Increasingly branched rolling circle amplification for the cancer gene detection

scientific article published on 28 July 2016

Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids.

scientific article published on 10 August 2015

Interspecies pharmacokinetics and in vitro metabolism of SQ109.

scientific article

Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells.

scientific article published on 28 November 2012

Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry

scientific article published on 6 May 2015

JS-K has potent anti-angiogenic activity in vitro and inhibits tumour angiogenesis in a multiple myeloma model in vivo.

scientific article

LC–MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501)

scientific article published on 24 May 2006

Long-stem shaped multifunctional molecular beacon for highly sensitive nucleic acids determination via intramolecular and intermolecular interactions based strand displacement amplification.

scientific article published on 30 October 2017

Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.

scientific article

Metapristone (RU486 metabolite) suppresses NSCLC by targeting EGFR-mediated PI3K/AKT pathway.

scientific article

Metapristone suppresses non-small cell lung cancer proliferation and metastasis via modulating RAS/RAF/MEK/MAPK signaling pathway.

scientific article published on 5 April 2017

Mifepristone inhibits ovarian cancer metastasis by intervening in SDF-1/CXCR4 chemokine axis

scientific article published on 17 July 2017

Mitaplatin increases sensitivity of tumor cells to cisplatin by inducing mitochondrial dysfunction.

scientific article published on 13 February 2012

Mitochondria and Nuclei Dual-Targeted Hollow Carbon Nanospheres for Cancer Chemophotodynamic Synergistic Therapy

scientific article published on 02 April 2019

Molybdenum disulfide-based hyaluronic acid-guided multifunctional theranostic nanoplatform for magnetic resonance imaging and synergetic chemo-photothermal therapy

scientific article published on 08 April 2019

Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993).

scientific article

Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells

scientific article

Nanoproteomics: a new sprout from emerging links between nanotechnology and proteomics.

scientific article published on 30 December 2012

Nanotechnology-based intelligent drug design for cancer metastasis treatment

scientific article

New molecular beacon for p53 gene point mutation and significant potential in serving as the polymerization primer.

scientific article

Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade.

scientific article published on 11 March 2014

Novel multifunction-integrated molecular beacon for the amplification detection of DNA hybridization based on primer/template-free isothermal polymerization.

scientific article published on 28 April 2015

Optimal structural design of mannosylated nanocarriers for macrophage targeting.

scientific article

PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.

scientific article published on February 2006

Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy ⬇️

scientific article published on May 18, 2013

Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug

scientific article

Pharmacokinetic differences of mifepristone between sexes in animals

scientific article published on 8 March 2018

Pharmacokinetics and metabolism study of isoboldine, a major bioactive component from Radix Linderae in male rats by UPLC-MS/MS.

scientific article published on 6 June 2015

Pharmacokinetics and pharmacodynamics of Phor21-betaCG(ala), a lytic peptide conjugate.

scientific article

Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats

scientific article published on 28 December 2010

Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas ⬇️

scientific article published on July 27, 2011

Physicochemistry, pharmacokinetics, and pharmacodynamics of S‐nitrosocaptopril crystals, a new nitric oxide donor††Abbreviations: CapNO, S‐nitrosocaptopril; Cap, Captopril; RSNOs, S‐nitrosothiols; ACE, angiotensin converting enzyme; MAP, me

scientific article published on 01 October 1999

Polynitrosylated proteins: characterization, bioactivity, and functional consequences.

scientific article published on May 1996

Potential serious interactions between nutraceutical ginseng and warfarin in patients with ischemic stroke

scientific article published on 29 December 2012

Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination ⬇️

scientific article published on November 18, 2010

Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent

scientific article published on 25 February 2012

Programmable nanoassembly consisting of two hairpin-DNAs for p53 gene determination

scientific article

Promising Compounds From Murraya exotica for Cancer Metastasis Chemoprevention.

scientific article published on 21 November 2016

Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS

scientific article published on 21 July 2006

RCA-enhanced multifunctional molecule beacon-based strand-displacement amplification for sensitive microRNA detection

RU486 Metabolite Inhibits CCN1/Cyr61 Secretion by MDA-MB-231-Endothelial Adhesion

scientific article published on 20 November 2019

Redox-responsive hyaluronic acid-functionalized graphene oxide nanosheets for targeted delivery of water-insoluble cancer drugs

scientific article published on 14 November 2018

S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells

scientific article published on 23 October 2018

S-nitrosocaptopril interrupts adhesion of cancer cells to vascular endothelium by suppressing cell adhesion molecules via inhibition of the NF-кB and JAK/STAT signal pathways in endothelial cells.

scientific article published on 24 August 2016

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

scientific article published in Nature

Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy

scientific article

Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite).

scientific article published on 7 December 2017

Similarities and differences between embryonic implantation and CTC invasion: Exploring the roles of abortifacients in cancer metastasis chemoprevention

scientific article published in 2022

Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

article

Simultaneous determination of three Panax notoginseng saponins at sub-nanograms by LC-MS/MS in dog plasma for pharmacokinetics of compound Danshen tablets.

scientific article published on 20 October 2010

Simultaneous estimation of pharmacokinetic properties in mice of three anti-tubercular ethambutol analogs obtained from combinatorial lead optimization.

scientific article published on 25 December 2004

Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: altered iron metabolism and its implication as an acute hemosiderin formation model

scientific article

Stepwise nanoassembly of a single hairpin probe and its biosensing

scientific article published on 09 May 2018

Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis

scientific article

Synthesis and biological evaluation of novel folic acid receptor-targeted, β-cyclodextrin-based drug complexes for cancer treatment

scientific article

Synthesis, spectral characterization, and in vitro cellular activities of metapristone, a potential cancer metastatic chemopreventive agent derived from mifepristone (RU486).

scientific article published on 18 January 2014

Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex.

scientific article

The Architecture and Function of Monoclonal Antibody-Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention.

scientific article

The conduct of drug metabolism studies considered good practice (II): in vitro experiments

scientific article published on December 2007

The effects of S-nitrosocaptopril on renal filtration and blood pressure in rats ⬇️

scientific article published on July 31, 1998

The paradigm-shifting idea and its practice: from traditional abortion Chinese medicine Murraya paniculata to safe and effective cancer metastatic chemopreventives.

scientific article published on 05 March 2016

The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology

scientific article

The unique pharmacological characteristics of mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis.

scientific article published on March 2014

Therapeutic strategies underpinning the development of novel techniques for the treatment of HIV infection.

scientific article

Thirty-day rat toxicity study reveals reversible liver toxicity of mifepristone (RU486) and metapristone.

scientific article published on 23 February 2016

Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption.

scientific article published on 10 August 2007

Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene.

scientific article published on 21 May 2016

UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma.

scientific article published on 15 December 2014

Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer

scientific article published on 01 January 2020

WDR74 induces nuclear β-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis

scientific article published on 12 December 2019

Warfarin and coumarin-like Murraya paniculata extract down-regulate EpCAM-mediated cell adhesion: individual components versus mixture for studying botanical metastatic chemopreventives

scientific article published on 02 August 2016

Paulina is supported by:

About Paulina

Help