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List of works by Susan L. Swain

Acculturation and tobacco use among Chinese Americans

scientific article published on 01 February 2004

Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells

scholarly article

Age-associated declines in immune system development and function: causes, consequences, and reversal

scientific article published on 23 July 2009

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

scientific article published on 08 October 2009

Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects ⬇️

scientific article published on 06 May 2012

Aging and immune function. Summary of a workshop held at Trudeau Institute, Saranac Lake, NY

scientific article published on 01 June 2005

Antigen presentation and the regulation of CD4 memory generation to influenza

scientific article

Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects ⬇️

scientific article published on September 15, 2010

Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses

scientific article published on October 2008

CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation

scientific article published on 06 May 2020

CD28 and ITK signals regulate autoreactive T cell trafficking.

scientific article

CD4 T cell defects in the aged: causes, consequences and strategies to circumvent

scientific article published on 15 January 2014

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

scientific article

CD4 T cell responses to influenza infection

scientific article published on June 2004

CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch

scientific article published on 01 September 2006

CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function

scientific article

CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.

scientific article

CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency

scientific article published on 01 October 2004

Control of innate immunity by memory CD4 T cells.

scientific article published on January 2011

Cytotoxic CD4 T cells in antiviral immunity

scientific article

Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.

scientific article published on 19 September 2016

Effect of age on naive CD4 responses: impact on effector generation and memory development

scientific article

Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2.

scientific article

Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates

scientific article published in April 2005

Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice

scientific article published on 01 February 2007

Expanding roles for CD4⁺ T cells in immunity to viruses.

scientific article published on 20 January 2012

Functionally diverse subsets in CD4 T cell responses against influenza.

scientific article published on 3 December 2008

Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes

scientific article published on 01 February 2003

Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection

scientific article published on 16 May 2014

Grand challenges in immunological memory

scientific article published on 20 December 2010

Homeostasis and the age-associated defect of CD4 T cells

scientific article

IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals

scientific article published on July 2007

IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge

scientific article published on June 2009

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans.

scientific article published on 14 June 2016

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

scientific article published on 31 March 2009

IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells

scientific article

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

article

IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo.

scientific article published in March 2017

IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age.

scientific article published on 7 April 2015

IL-7 promotes the transition of CD4 effectors to persistent memory cells

scientific article

IL-7: maintaining T-cell memory and achieving homeostasis

scientific article

Immune senescence: new insights into defects but continued mystery of root causes

scientific article published on 17 August 2013

Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects

scientific article published in April 2008

Induction of CD4 T cell changes in murine AIDS is dependent on costimulation and involves a dysregulation of homeostasis

scientific article published in July 2002

Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo

scientific article published on May 2004

Influencing the fates of CD4 T cells on the path to memory: lessons from influenza.

scientific article published on 25 March 2008

Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production

scientific article published on 14 September 2020

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

scientific article

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

scientific article

Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza

scientific article

Key research opportunities in immune system aging

scientific article published on 27 February 2009

Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation

scientific article

Location, location, location: the impact of migratory heterogeneity on T cell function

scientific article published on 08 October 2013

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful ⬇️

scientific article published on May 25, 2013

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation

scientific article published on 14 August 2019

Memory CD4+ T cells induce innate responses independently of pathogen

scientific article

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms

scientific article

Memory CD4+T-cell–mediated protection depends on secondary effectors that are distinct from and superior to primary effectors ⬇️

scientific article published on August 27, 2012

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection ⬇️

scientific article published on April 4, 2012

Multiple Redundant Effector Mechanisms of CD8+ T Cells Protect against Influenza Infection ⬇️

scientific article published on November 28, 2012

Multipronged CD4+ T‐cell effector and memory responses cooperate to provide potent immunity against respiratory virus ⬇️

scientific article published on September 1, 2013

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection

scientific article published on 28 December 2016

New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza

scientific article

Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

scientific article

Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection

scientific article published on 26 September 2012

Original Antigenic Sin: Friend or Foe in Developing a Broadly Cross-Reactive Vaccine to Influenza?

scientific article published on 01 March 2019

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion

scientific article published on May 2016

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion

scientific article published on 01 June 2016

Pathogen Recognition by CD4 Effectors Drives Key Effector and Most Memory Cell Generation Against Respiratory Virus

scientific article published on 26 March 2018

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response

scientific article published on 01 June 2007

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus

scientific article published in January 2007

Rapid default transition of CD4 T cell effectors to functional memory cells

scientific article

Regulation of CD4+ T-cell contraction during pathogen challenge

scientific article published on July 2010

Regulation of memory CD4 T cells: generation, localization and persistence

scientific article

Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells

scientific article

Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells

scientific article published in December 2002

Repeated stimulation of CD4 effector T cells can limit their protective function

scientific article

SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells

scientific article published on 01 July 2006

SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation

scientific article published on September 2008

SAP is required for Th cell function and for immunity to influenza

scientific article

Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory.

scientific article

T cell responses to influenza virus infection: effector and memory cells

scientific article published in January 2004

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

scientific article

T-cell immunosenescence: lessons learned from mouse models of aging

scientific article published on 21 June 2009

TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism ⬇️

scientific article published on October 27, 2010

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge

scientific article published on March 2009

Thanks for the memory!

scientific article published in October 2005

The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.

scientific article

The effector to memory transition of CD4 T cells.

scientific article published on January 2008

The potential of CD4 T-cell memory

scientific article published on 16 March 2010

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age.

scientific article

Uneven distribution of MHC class II epitopes within the influenza virus

scientific article

Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

scientific article

Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation

scientific article published on 29 December 2006

Vaccines against pandemic influenza.

scientific article

Virus-induced natural killer cell lysis of T cell subsets

scientific article published on 18 October 2019

Why aging T cells fail: implications for vaccination

scientific article published on June 2006

c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival

scientific article published on January 2008

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