List of works by Andrew M Stern

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.

scientific article published on 08 March 2016

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

scientific article

A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes

scientific article published on 01 January 2018

A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases

scientific article published on July 1994

A high-content, multiplexed screen in human breast cancer cells identifies profilin-1 inducers with anti-migratory activities

scientific article

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

scientific article

Biologically Relevant Heterogeneity: Metrics and Practical Insights

scientific article published on 06 January 2017

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.

scientific article published on 6 January 2018

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

scientific article published on 19 December 2017

Development of a carbon dioxide-capture assay in microtiter plate for aspartyl-beta-hydroxylase

scientific article published in July 1999

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

scientific article published on 18 August 2016

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.

scientific article

Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture ⬇️

scientific article published on January 10, 1996

Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression, fibrinogen binding, and microaggregate formation in a phase I dose-finding study: no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa a

scientific article

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published on 16 September 2015

Evidence that thrombocytopenia observed in humans treated with orally bioavailable glycoprotein IIb/IIIa antagonists is immune mediated

scientific article

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

scientific article published on December 2002

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis

scientific article published on 01 October 2000

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

scientific article

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery

scientific article (publication date: 2014)

Influence of a natural and a synthetic inhibitor of factor XIIIa on fibrin clot rheology.

scientific article

Invertebrate aspartyl/asparaginyl beta-hydroxylase: potential modification of endogenous epidermal growth factor-like modules.

scientific article published on November 1992

Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity.

scientific article

Mutation site and context dependent effects of ESR1 mutation in genome-edited breast cancer cell models.

scientific article

Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.

scientific article published on December 2002

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

scientific article published on 4 February 2015

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

scientific article

Novel inhibitors against the transglutaminase-catalysed crosslinking of lens proteins.

scientific article published in May 1998

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma

scientific article

Peripheral metabolism of [35S]parathyroid hormone in vivo: influence of alterations in calcium availability and parathyroid status

scientific article published on 01 July 1989

Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.

scientific article published in November 2017

Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.

scientific article published on 29 November 2016

Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

scientific article

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

scientific article published on 01 November 2000

Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia

scientific article

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

RETRACTED scientific article

Regulation of clot retraction by glycoprotein IIb/IIIa antagonists.

scientific article published in November 2002

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones

scientific article published on 01 August 2000

Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients

scientific article published on 23 October 2015

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks

scientific article published on 14 July 2020

The five cysteine residues located in the active site region of bovine aspartyl (asparaginyl) beta-hydroxylase are not essential for catalysis

scientific article published on 01 September 1998

Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation

scientific article published on 01 August 1994

Treating gynecologic malignancies with selective estrogen receptor downregulators (SERDs): promise and challenges.

scientific article

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