List of works - Sofie Demeyer

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

scientific article (publication date: 5 September 2014)

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

scientific article (publication date: October 2015)

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

scientific article

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.

scientific article published on 30 August 2017

HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.

scientific article published in March 2018

RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications

scientific article published on 05 May 2016

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.

scientific article

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

scientific article published on 20 November 2017

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

scientific article published on 29 November 2017

Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing

scientific article published on 8 March 2016

The Index-based Subgraph Matching Algorithm with General Symmetries (ISMAGS): exploiting symmetry for faster subgraph enumeration

scientific article (publication date: 2014)

Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia

scientific article published on 05 May 2016

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

scientific article published on 06 July 2021

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

scientific article published in 2022

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

scientific article published on 01 October 2019

Unlocking the Complexity: Exploration of Acute Lymphoblastic Leukemia at the Single Cell Level

scientific article published on 27 August 2024

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

scientific article published on 01 September 2021

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

scientific article published in 2023

Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia

BCR-ABL1 positive B-ALL can undergo T-cell lineage shift to become CD19 negative T-ALL

scientific article published on 19 April 2018

Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

correction of a scholarly article

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

scientific article published on 8 December 2022

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

scientific article published on 21 August 2020

List of works by Sofie Demeyer

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.

HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.

RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing

The Index-based Subgraph Matching Algorithm with General Symmetries (ISMAGS): exploiting symmetry for faster subgraph enumeration

Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Unlocking the Complexity: Exploration of Acute Lymphoblastic Leukemia at the Single Cell Level

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia

Single-cell CRISPR screening characterizes transcriptional deregulation in T-cell acute lymphoblastic leukemia

BCR-ABL1 positive B-ALL can undergo T-cell lineage shift to become CD19 negative T-ALL

Author Correction: PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia