List of works - Karim Malik

A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis

scientific article

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

scientific article published on 23 March 2020

A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway

scientific article

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

scientific article

Autoregulation of the human WT1 gene promoter

article

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

scientific article published on 01 November 2018

Characterization of 17.94, a novel anaplastic Wilms' tumor cell line

scientific article published in June 2012

Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2.

scientific article

Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.

scientific article

Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes

scientific article published on 12 December 2019

Epigenetic gene deregulation in cancer.

scientific article

Frequency and Timing of Loss of Imprinting at 11p13 and 11p15 in Wilms' Tumor Development

article

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor

scientific article

Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastoma

scientific article

Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours

scientific article published on 17 December 2003

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter

scientific article published on 17 February 2015

Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors

scientific article

Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development

scientific article published on 12 April 2007

Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells.

scientific article published on November 2006

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

scientific article

Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

scientific article

MYCN is recruited to the RASSF1A promoter but is not critical for DNA hypermethylation in neuroblastoma ⬇️

scientific article published on December 31, 2012

PRMT1 promotes neuroblastoma cell survival through ATF5

scientific article published on 15 May 2020

Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells

scientific article

The molecular biology of Wilms' tumour

scientific article published on 14 May 2001

The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour

scientific article

The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines

scientific article published in September 2003

The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis

scientific article

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma

scientific article published on 28 March 2017

Transactivation of the WT1 antisense promoter is unique to the WT1[+/−] isoform

scientific article published on 01 July 1999

Wilms' tumor: a paradigm for the new genetics.

scientific article

Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages

scientific article published on 16 April 2019

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma

scientific article published on 2 March 2018

List of works by Karim Malik

A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Autoregulation of the human WT1 gene promoter

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

Characterization of 17.94, a novel anaplastic Wilms' tumor cell line

Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2.

Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.

Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes

Epigenetic gene deregulation in cancer.

Frequency and Timing of Loss of Imprinting at 11p13 and 11p15 in Wilms' Tumor Development

Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor

Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastoma

Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours

Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter

Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors

Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development

Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells.

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

MYCN is recruited to the RASSF1A promoter but is not critical for DNA hypermethylation in neuroblastoma ⬇️

PRMT1 promotes neuroblastoma cell survival through ATF5

Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells

The molecular biology of Wilms' tumour

The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour

The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines

The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma

Transactivation of the WT1 antisense promoter is unique to the WT1[+/−] isoform

Wilms' tumor: a paradigm for the new genetics.

Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages

Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma

Wnt signalling drives context-dependent differentiation or proliferation in neuroblastoma