List of works - Jeffrey J Saucerman

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

scientific article

Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy

scientific article

Automated image analysis of cardiac myocyte Ca2+ dynamics

scientific article

Bigger, better, faster: principles and models of AKAP anchoring protein signaling

scientific article

Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes ⬇️

scientific article published on June 12, 2011

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes

scientific article

Cardiac biexcitability: two ways to catch a wave

scientific article published on 03 September 2011

Computational models reduce complexity and accelerate insight into cardiac signaling networks

scientific article

Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy

scientific article published on 18 December 2020

Cytokine screening identifies NICU patients with Gram-negative bacteremia

scientific article

Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.

scientific article

Endotoxin depresses heart rate variability in mice: cytokine and steroid effects

scientific article

Erratum: Corrigendum: Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

scholarly article published in Nature Chemical Biology

Graphical approach to model reduction for nonlinear biochemical networks

scientific article

Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages

scientific article

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

scientific article published on 24 January 2024

Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.

scientific article published on June 2004

Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

scientific article

Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy

scientific article published in June 2024

Multiscale model of heart growth during pregnancy: integrating mechanical and hormonal signaling

scientific article published on 6 June 2022

Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues

scientific article published on 06 January 2021

Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling

scientific article

PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling

scientific article

Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy ⬇️

scientific article published on January 20, 2012

Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.

scientific article published on 4 November 2004

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.

scientific article

Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty ⬇️

scientific article published on August 31, 2011

Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2+ Handling ⬇️

scientific article published on October 6, 2010

Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes

scholarly article

Systems analysis of small signaling modules relevant to eight human diseases

scientific article

Whole-genome metabolic network reconstruction and constraint-based modeling

scientific article

List of works by Jeffrey J Saucerman

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy

Automated image analysis of cardiac myocyte Ca2+ dynamics

Bigger, better, faster: principles and models of AKAP anchoring protein signaling

Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes ⬇️

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes

Cardiac biexcitability: two ways to catch a wave

Computational models reduce complexity and accelerate insight into cardiac signaling networks

Context-specific network modeling identifies new crosstalk in β-adrenergic cardiac hypertrophy

Cytokine screening identifies NICU patients with Gram-negative bacteremia

Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.

Endotoxin depresses heart rate variability in mice: cytokine and steroid effects

Erratum: Corrigendum: Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

Graphical approach to model reduction for nonlinear biochemical networks

Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages

Logic-based mechanistic machine learning on high-content images reveals how drugs differentially regulate cardiac fibroblasts

Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.

Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model

Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy

Multiscale model of heart growth during pregnancy: integrating mechanical and hormonal signaling

Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues

Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling

PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling

Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy ⬇️

Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP.

Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty ⬇️

Synergy between CaMKII Substrates and β-Adrenergic Signaling in Regulation of Cardiac Myocyte Ca2+ Handling ⬇️

Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes

Systems analysis of small signaling modules relevant to eight human diseases

Whole-genome metabolic network reconstruction and constraint-based modeling