List of works - Sandra Hervas-Stubbs

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

scientific article published on 25 January 2011

Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses

scientific article published on 11 March 2014

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

scientific article published on 14 July 2014

Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.

scientific article

Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor.

scientific article published on 13 May 2017

CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.

scientific article

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis

scientific article published on 15 September 2015

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

scientific article

Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.

scientific article published on 12 September 2013

Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming

scientific article

Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal.

scientific article published in March 2005

Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

scientific article published on 06 July 2010

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

scientific article published on 27 October 2010

Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes

scientific article

Direct effects of type I interferons on cells of the immune system

scientific article published on 03 March 2011

Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells

scientific article published in December 2010

Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis

scientific article published on 10 July 2014

Evaluation of Monocytes as Carriers for Armed Oncolytic Adenoviruses in Murine and Syrian Hamster Models of Cancer ⬇️

scientific article published on October 26, 2012

Evaluation of a Salmonella Strain Lacking the Secondary Messenger C-di-GMP and RpoS as a Live Oral Vaccine

scientific article

Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.

scientific article published on 18 May 2017

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

scientific article published on 30 June 2015

High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection

scientific article

High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts.

scientific article published in March 2004

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.

scientific article published on December 2016

Identification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy

scientific article published on 14 December 2015

Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena

scientific article published on 01 April 2006

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

scientific article published on 25 January 2018

In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.

scientific article

Induction of neutralizing antibodies by a tobacco chloroplast-derived vaccine based on a B cell epitope from canine parvovirus

scientific article published on 02 September 2005

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.

scientific article

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

scientific journal article

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates

scientific article

Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells.

scientific article published on 14 February 2008

Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.

scientific article published on January 2011

Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy

scientific article

Long-Term Systemic Expression of a Novel PD-1 Blocking Nanobody from an AAV Vector Provides Antitumor Activity without Toxicity

scientific article published on 02 December 2020

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

scientific article published on 27 June 2016

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.

scientific article published on July 2008

Neoantigens as potential vaccines in hepatocellular carcinoma

scientific article published on 01 February 2022

Overcoming class II-linked non-responsiveness to hepatitis B vaccine

scientific article published on 01 August 1994

Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.

scientific article published on 20 September 2010

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas

scientific article published on 11 April 2019

PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.

scientific article

Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.

scientific article published on 2 November 2011

Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.

scientific article

Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.

scientific article published on 19 April 2006

Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity

article

Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12.

scientific article published on 19 December 2014

TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help.

scientific article published on 5 March 2007

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

scientific article published on 19 June 2012

The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer

scientific article published on 21 December 2017

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.

scientific article published on September 2007

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo

scientific article published on 01 January 2007

The immunological profile of tumor-bearing animals determines the outcome of cancer immunotherapy ⬇️

scientific article published on April 16, 2013

Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma

scientific article published on November 2008

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection.

scientific article published in October 1997

Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver

scientific article published on 10 May 2014

Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

scientific article published on 01 May 2022

List of works by Sandra Hervas-Stubbs

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.

Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein.

Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor.

CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model.

Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming

Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal.

Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes

Direct effects of type I interferons on cells of the immune system

Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8(+) T cells

Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis

Evaluation of Monocytes as Carriers for Armed Oncolytic Adenoviruses in Murine and Syrian Hamster Models of Cancer ⬇️

Evaluation of a Salmonella Strain Lacking the Secondary Messenger C-di-GMP and RpoS as a Live Oral Vaccine

Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection

High-yield expression of a viral peptide animal vaccine in transgenic tobacco chloroplasts.

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.

Identification of TIM3 2'-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy

Immunogenic cell death and cross-priming are reaching the clinical immunotherapy arena

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb.

Induction of neutralizing antibodies by a tobacco chloroplast-derived vaccine based on a B cell epitope from canine parvovirus

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates

Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells.

Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.

Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy

Long-Term Systemic Expression of a Novel PD-1 Blocking Nanobody from an AAV Vector Provides Antitumor Activity without Toxicity

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies.

Neoantigens as potential vaccines in hepatocellular carcinoma

Overcoming class II-linked non-responsiveness to hepatitis B vaccine

Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas

PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.

Pilot clinical trial of type 1 dendritic cells loaded with autologous tumor lysates combined with GM-CSF, pegylated IFN, and cyclophosphamide for metastatic cancer patients.

Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.

Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.

Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity

Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12.

TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help.

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo

The immunological profile of tumor-bearing animals determines the outcome of cancer immunotherapy ⬇️

Therapeutic antitumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection.

Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver

Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer