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List of works by Tullio Florio

17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease

scientific article published on October 2010

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

scientific article

A novel collection of snRNA-like promoters with tissue-specific transcription properties

scientific article

A novel mechanism for the melatonin inhibition of testosterone secretion by rat Leydig cells: reduction of GnRH-induced increase in cytosolic Ca2+

scientific article published on 01 December 1999

A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing.

scientific article published on 26 February 2013

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.

scientific article published on 29 December 2016

Adiponectin as novel regulator of cell proliferation in human glioblastoma.

scientific article published on October 2014

Adult pituitary stem cells: from pituitary plasticity to adenoma development

scientific article

Age-related alterations of somatostatin gene expression in different rat brain areas ⬇️

scientific article published on August 23, 1991

Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

scientific article published on January 2007

Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells

scientific article published on January 2007

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling

scientific article published on 21 February 2007

Amyloid precursor protein and presenilin involvement in cell signaling.

scientific article published on January 2007

Amyloid-β protein precursor regulates phosphorylation and cellular compartmentalization of microtubule associated protein tau.

scientific article published in January 2012

An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells.

scientific article published on 25 June 2010

An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the disease

scientific article

An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta

scientific journal article

An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples.

scientific article published on 20 September 2012

Anterior pituitary adenosine receptors, coupled to adenylate cyclase, modulate prolactin release

scientific article published on 01 November 1989

Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?

scientific article published on 10 April 2017

Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment 106-126

scientific article published on 01 August 2000

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

scientific article published on 19 February 2019

Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins.

scientific article

Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms

scientific article published on 13 August 2019

CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment

scientific article

CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis.

scientific article

Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

scientific article

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

scientific article published on 18 November 2014

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

scientific article published on 24 May 2016

Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

scientific article

Chemokines and chemokine receptors: new actors in neuroendocrine regulations.

scientific article published on 17 July 2010

Chemokines and their receptors in the CNS: expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation.

scientific article published on April 2003

Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets

scientific article

Co-Administration of Fendiline Hydrochloride Enhances Chemotherapeutic Efficacy of Cisplatin in Neuroblastoma Treatment

scientific article published on 10 November 2020

Combined chemotherapy with cytotoxic and targeted compounds for the management of human malignant pleural mesothelioma.

scientific article published on 26 May 2011

Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.

scientific article published in November 2017

Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic

article

Cross talk between mesenchymal and glioblastoma stem cells: Communication beyond controversies

scientific article published on 15 June 2020

Cultured astrocyte proliferation induced by extracellular guanosine involves endogenous adenosine and is raised by the co-presence of microglia

scientific article published on 01 February 2000

Cytosolic calcium rise induced by maitotoxin in PC12 cells: effect of omega-conotoxin (GVIA)

scientific article published on 01 September 1990

Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects.

scientific article published on 2 March 2018

Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.

scientific article

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

scientific article published on 25 May 2017

Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants

scientific article published on 04 October 2007

Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

scientific article published on 10 August 2012

Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin.

scientific article published in November 1989

Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment

scientific article published on 01 March 1991

Does pasireotide directly modulate skeletal muscle metabolism?

scientific article

Down-regulation of 21A Alu RNA as a tool to boost proliferation maintaining the tissue regeneration potential of progenitor cells.

scientific article published on 5 August 2016

Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma

scientific article published on 6 September 2016

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

scientific article published on 05 October 2015

Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

scientific article published on 26 February 2009

EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms.

scientific article

ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation

scientific article published on 01 November 2007

Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats.

scientific article published in June 1993

Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part II: Modulation of calcium fluxes.

scientific article published on September 1988

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity

article

Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study.

scientific article published in June 2008

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

scientific article

Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells

scientific article published on 18 November 2019

Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

scientific article

Emerging Therapies in Pheochromocytoma and Paraganglioma: Immune Checkpoint Inhibitors in the Starting Blocks

scientific article published on 29 December 2020

Emerging multitarget tyrosine kinase inhibitors in the treatment of neuroendocrine neoplasms.

scientific article

Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment

scientific article published on 2 August 2012

Exosomes and Extracellular Vesicles as Emerging Theranostic Platforms in Cancer Research

scientific article published on 01 December 2020

Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

scientific article published in July 2002

Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: role of CXCR4 and SDF1 in glioma cell proliferation and migration.

scientific article published on 18 April 2006

Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature.

scientific article published on 11 February 2011

Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity.

scientific article published in January 2004

FGFR4 Polymorphism as Molecular Determinant of the Efficacy of mTOR Inhibitors In GH-Secreting Pituitary Adenomas

scientific article published on 01 September 2016

G protein activation of a hormone-stimulated phosphatase in human tumor cells.

scientific article

Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation.

scientific article published in March 2010

Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1

scientific article published on 01 December 1999

Goat anti-human GM-CSF recognizes canine GM-CSF

scientific article published in March 2012

High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein

scientific article published on 19 November 2010

Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells

scientific article published on 29 May 2019

In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a "2-Aminoimidazole plus Aromatic Group" Scaffold.

scientific article published on 23 February 2018

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

scientific article

In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity

scientific article

In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas

scientific article published on 01 October 2002

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

scientific article

In vivo and in vitro response to octreotide LAR in a TSH-secreting adenoma: characterization of somatostatin receptor expression and role of subtype 5

scientific article published on 18 November 2010

Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity.

scientific article published on 21 October 2013

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

scientific article published on 21 August 2018

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells.

scientific article published on 27 October 2016

Interleukin 6 modulation of second messenger systems in anterior pituitary cells.

scientific article published on January 1992

Interleukin I modulation of anterior pituitary function: effect on hormone release and second messenger systems

scientific article published on 01 November 1989

Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects

scientific article

Intracellular calcium rise through L-type calcium channels, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation.

scientific article

Intracellular signalling mediating HIV-1 gp120 neurotoxicity.

scientific article published on February 1998

Intracellular transducing mechanisms coupled to brain somatostatin receptors.

scientific article published on June 1996

Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential.

scientific article published on 16 February 2012

MCM2 and Carbonic Anhydrase 9 Are Novel Potential Targets for Neuroblastoma Pharmacological Treatment

scientific article published on 03 November 2020

Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA.

scientific article published on 2 July 2014

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

scientific article

Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.

scientific article published on 19 December 2012

Minimalist hybrid ligand/receptor-based pharmacophore model for CXCR4 applied to a small-library of marine natural products led to the identification of phidianidine a as a new CXCR4 ligand exhibiting antagonist activity.

scientific article

Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D1 and D2 dopamine receptors: involvement of G proteins in the development of receptor supersensitivity.

scientific article published on November 1992

Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

scientific article published on 04 August 2015

Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats

scientific article (publication date: September 1992)

Molecular mechanisms of the antiproliferative activity of somatostatin receptors (SSTRs) in neuroendocrine tumors.

scientific article published on January 2008

Mutual Influence of ROS, pH, and CLIC1 Membrane Protein in the Regulation of G1-S Phase Progression in Human Glioblastoma Stem Cells

scientific article published on 22 August 2018

NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid β secretion

scientific article published on 10 May 2012

Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling

scientific article published on 08 February 2012

Neuroendocrine tumors: insights into innovative therapeutic options and rational development of targeted therapies.

scientific article published on 27 October 2013

New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells

scientific article published on 02 January 2014

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.

scientific article published on 22 September 2016

PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs

scientific article

Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures

article

Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors.

scientific article published on 2 August 2016

Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA.

scientific article

Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay.

scientific article

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

scientific article published on 7 February 2018

Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas.

scientific article

Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes

scientific article published on 01 January 1999

Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma ⬇️

scientific article published on May 1, 2012

Primary Cultures from Human GH-secreting or Clinically Non-functioning Pituitary Adenomas

publication published on 05 April 2018

Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

scientific article published on December 2003

Pyrrolidinedithiocarbamate induces apoptosis in cerebellar granule cells: involvement of AP-1 and MAP kinases.

scientific article published in July 2003

Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets

scientific article

Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

scientific article published on January 2012

Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels

scientific article published on 01 December 1988

Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target

scientific article

Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation

scientific article

SDF-1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2.

scientific article published on December 2006

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells

scientific article published on 19 February 2016

Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1)

scientific article published on 01 January 1999

Somatostatin analogues, a series of tissue transglutaminase inducers, as a new tool for therapy of mesenchimal tumors of the gastrointestinal tract

scientific article published on 06 February 2007

Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro

scientific article published on 01 October 1999

Somatostatin inhibition of adenylate cyclase activity in different brain areas

scientific article published on 01 July 1989

Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation.

scientific article published on 30 June 2008

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

scientific article published on April 2003

Somatostatin receptor subtype-dependent regulation of nitric oxide release: involvement of different intracellular pathways.

scientific article published on 23 September 2004

Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2.

scientific article published on 19 June 2008

Somatostatin/somatostatin receptor signalling: phosphotyrosine phosphatases.

scientific article published on 31 August 2007

Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures.

scientific article published on 16 January 2013

Sprouty2 enhances the tumorigenic potential of glioblastoma cells.

scientific article published on 23 February 2018

Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay

scientific article published on 01 December 1988

The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation

scientific article

The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.

scientific article published on November 2015

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

scientific article published on 25 May 2017

The pathological prion protein forms ionic conductance in lipid bilayer

scientific article published on 6 June 2011

The somatostatin receptor SSTR1 is coupled to phosphotyrosine phosphatase activity in CHO-K1 cells

scientific article published on 01 October 1994

The status of the art of human malignant glioma management: the promising role of targeting tumor-initiating cells.

scientific article published on 13 June 2012

The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants

scientific journal article

Tryptophan hydroxylase 2 (TPH2) in a neuronal cell line: modulation by cell differentiation and NRSF/rest activity.

scientific article published on 28 September 2012

p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells

scientific article published on February 2002

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