List of works - Mike Schutkowski

A 1-phytase type III effector interferes with plant hormone signaling

scientific article published on 18 December 2017

A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases

scientific article

A Protease-Free Assay for Peptidyl Prolylcis/transIsomerases Using Standard Peptide Substrates

article by B. Janowski et al published October 1997 in Analytical Biochemistry

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions ⬇️

scientific article

Affinity profiling using the peptide microarray technology: a case study

scientific article published on 4 January 2007

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

scientific article

Antibody signatures defined by high-content peptide microarray analysis

Antibody signatures defined by high-content peptide microarray analysis.

scientific article published in January 2010

Architektur von Protein-Ligand-Bindungsstellen durch templatassistierte intramolekulare Peptid-Peptid-Interaktionen

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

scientific article published on 3 February 2017

Branches on the alpha-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding.

scientific article published in July 2004

Branches on the α-C Atom of Cyclosporin A Residue 3 Result in Direct Calcineurin Inhibition and Rapid Cyclophilin 18 Binding

scholarly article by Yixin Zhang published in September 2004

ChemInform Abstract: Extremely Selective Mg(ClO4)2-Mediated Removal of Bpoc/Ddz Moieties Suitable for the Solid Phase Peptide Synthesis of Thioxo Peptides

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors

scientific article

Conformational state of a 25-mer peptide from the cyclophilin-binding loop of the HIV type 1 capsid protein.

scientific article published on August 1997

Crystal structure analysis of human Sirt2 and its ADP-ribose complex

scientific article

Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29

scientific article

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

scientific article published on 15 November 2017

Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity

scientific article

Cyclophilin-binding motifs and the HIV-1 p26 gag/cyclophilin interaction

article

Deciphering enzyme function using peptide arrays

scientific article

Enhancing the Proline Effect: Pseudo-Prolines for TailoringCis/TransIsomerization

scientific article published in 1998

Epitope mapping protocols. Preface

scientific article published on 01 January 2009

Evidence for the Absolute Conformational Specificity of the Intestinal H+/Peptide Symporter, PEPT1

scientific article published in Journal of Biological Chemistry

Evidence that the substrate backbone conformation is critical to phosphorylation by p42 MAP kinase

article

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

scientific article

Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney

scientific article

Extremely mild reagent for Boc deprotection applicable to the synthesis of peptides with thioamide linkages

article

HDAC11 is a fatty-acid deacylase

High density peptide microarrays for proteome-wide fingerprinting of kinase activities in cell lysates

scientific article published on January 2010

High-content peptide microarrays for deciphering kinase specificity and biology.

scientific article published in May 2004

High-density peptide microarrays for reliable identification of phosphorylation sites and upstream kinases

scientific article published on January 2009

Histone Deacetylase 11 Is a Fatty-Acid Deacylase

scientific article published on 16 January 2018

Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.

scientific article published on 9 April 2011

Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays.

scientific article published on 19 May 2015

Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts

scientific article

Identification of sortase substrates by specificity profiling

scientific article published on 22 June 2017

Influence on proline-specific enzymes of a substrate containing the thioxoaminoacyl-prolyl peptide bond.

scientific article

Inhibition of peptidyl-prolyl cis/trans isomerase activity by substrate analog structures: thioxo tetrapeptide-4-nitroanilides

scientific article published on 01 October 1995

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation

scientific article published on 26 February 2013

Intramolecular Assistance ofcis/transIsomerization of the Histidine−Proline Moiety†

scientific article published in 1997

Is the cis-trans isomerization of cyclophilin involved in HIV-1 infectivity?

article

Kinetic analysis of the unfolding and refolding of ribonuclease T1 by a stopped-flow double-mixing technique

scientific article

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

scientific article

Major histocompatibility complex class II molecule-human immunodeficiency virus peptide analysis using a microarray chip

scientific article published on 18 February 2009

Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases

scientific article

Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2.

scientific article published on 10 November 2017

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

scientific article (publication date: 2 August 2002)

Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries

scientific article

New assays and approaches for discovery and design of Sirtuin modulators

scientific article published on 02 January 2014

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

scientific article published on 14 November 2019

P143-M Microarray-Generated Phosphopeptide Selectivity Profiles for Fluorescent Conjugates of an Artificial Phosphomonoester-Binding Small Molecule; Implications for the Global Enrichment and Detection of Phosphopeptides and Phosphoproteins.

scientific article published in February 2007

PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation

scientific article

Parvulin 17 promotes microtubule assembly by its peptidyl-prolyl cis/trans isomerase activity

scientific article

Pattern recognition in pulmonary tuberculosis defined by high content peptide microarray chip analysis representing 61 proteins from M. tuberculosis

scientific article

Peptide Arrays in Proteomics and Drug Discovery

article

Peptide Arrays on Solid Supports: A Tool for the Identification of Peptide Ligands

Peptide Microarrays for Profiling of Epigenetic Targets

Peptide arrays for enzyme profiling

scientific article

Peptide arrays for kinase profiling

scientific article

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46

scientific article

Peptide microarrays for profiling of modification state-specific antibodies

scientific article published in January 2009

Potent and Selective Inhibitors of Human Sirtuin 5.

scientific article published in March 2018

Probing Substrate Backbone Function in Prolyl Oligopeptidase Catalysis. Large Positional Effects of Peptide Bond Monothioxylation

scientific article published on 01 April 1997

Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease.

scientific article published in January 2009

Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and fluorescence-based assays

scientific article

Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition†

article

Rotational Barriers ofcis/transIsomerization of Proline Analogues and Their Catalysis by Cyclophilin§

scientific article published in 1997

SIRT5 regulation of ammonia-induced autophagy and mitophagy

scientific article published in January 2015

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

scientific article

Separation of cis/trans isomers of a prolyl peptide bond by capillary zone electrophoresis.

scientific article

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

scientific article

Serotyping of Toxoplasma gondii in cats (Felis domesticus) reveals predominance of type II infections in Germany

scientific article

Side-chain effects on peptidyl-prolyl cis/trans isomerisation.

scientific article published in June 1998

Sirt1 activation by resveratrol is substrate sequence-selective

scientific article

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition

scientific article

Solid-phase synthesis of peptide-4-nitroanilides

SpikeTides™—proteotypic peptides for large-scale MS-based proteomics

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

scientific article published on 2 December 2010

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

scientific article

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules

article

Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening

scientific article

Substrate-based design of reversible Pin1 inhibitors

scientific article

Synthesis of a chromogenic proline-containing glycopeptide

Synthesis of dipeptide 4-nitroanilides containing non-proteinogenic amino acids

scientific article published on 01 March 1995

Synthetic peptide arrays for pathway-level protein monitoring by liquid chromatography-tandem mass spectrometry

scientific article

Target specificity analysis of the Abl kinase using peptide microarray data

scientific article

The SH2 domain interaction landscape

scientific article

The architecture of protein-ligand binding sites revealed through template-assisted intramolecular peptide-peptide interactions

scientific article

The peptide microarray "ChloroPhos1.0" identifies new phosphorylation targets of plastid casein kinase II (pCKII) in Arabidopsis thaliana

scientific article

The protein interaction network mediated by human SH3 domains

scientific article published on 29 June 2011

The solid-phase synthesis of side-chain-phosphorylated peptide-4-nitroanilides

scientific article published on 01 August 1997

The speed limit for protein folding measured by triplet-triplet energy transfer.

scientific article

The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters

scientific article published on 18 September 2015

Type III restriction endonuclease EcoP15I is a heterotrimeric complex containing one Res subunit with several DNA-binding regions and ATPase activity

scientific article published on 23 December 2011

Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression.

scientific article

Validation of peptide epitope microarray experiments and extraction of quality data

scientific article

Whole CMV proteome pattern recognition analysis after HSCT identifies unique epitope targets associated with the CMV status

scientific article

List of works by Mike Schutkowski

A 1-phytase type III effector interferes with plant hormone signaling

A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases

A Protease-Free Assay for Peptidyl Prolylcis/transIsomerases Using Standard Peptide Substrates

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions ⬇️

Affinity profiling using the peptide microarray technology: a case study

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

Antibody signatures defined by high-content peptide microarray analysis

Antibody signatures defined by high-content peptide microarray analysis.

Architektur von Protein-Ligand-Bindungsstellen durch templatassistierte intramolekulare Peptid-Peptid-Interaktionen

Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

Branches on the alpha-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding.

Branches on the α-C Atom of Cyclosporin A Residue 3 Result in Direct Calcineurin Inhibition and Rapid Cyclophilin 18 Binding

ChemInform Abstract: Extremely Selective Mg(ClO4)2-Mediated Removal of Bpoc/Ddz Moieties Suitable for the Solid Phase Peptide Synthesis of Thioxo Peptides

Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors

Conformational state of a 25-mer peptide from the cyclophilin-binding loop of the HIV type 1 capsid protein.

Crystal structure analysis of human Sirt2 and its ADP-ribose complex

Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity

Cyclophilin-binding motifs and the HIV-1 p26 gag/cyclophilin interaction

Deciphering enzyme function using peptide arrays

Enhancing the Proline Effect: Pseudo-Prolines for TailoringCis/TransIsomerization

Epitope mapping protocols. Preface

Evidence for the Absolute Conformational Specificity of the Intestinal H+/Peptide Symporter, PEPT1

Evidence that the substrate backbone conformation is critical to phosphorylation by p42 MAP kinase

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

Extended investigation of the substrate specificity of dipeptidyl peptidase IV from pig kidney

Extremely mild reagent for Boc deprotection applicable to the synthesis of peptides with thioamide linkages

HDAC11 is a fatty-acid deacylase

High density peptide microarrays for proteome-wide fingerprinting of kinase activities in cell lysates

High-content peptide microarrays for deciphering kinase specificity and biology.

High-density peptide microarrays for reliable identification of phosphorylation sites and upstream kinases

Histone Deacetylase 11 Is a Fatty-Acid Deacylase

Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.

Identification of peptidic substrates for the human kinase Myt1 using peptide microarrays.

Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts

Identification of sortase substrates by specificity profiling

Influence on proline-specific enzymes of a substrate containing the thioxoaminoacyl-prolyl peptide bond.

Inhibition of peptidyl-prolyl cis/trans isomerase activity by substrate analog structures: thioxo tetrapeptide-4-nitroanilides

Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation

Intramolecular Assistance ofcis/transIsomerization of the Histidine−Proline Moiety†

Is the cis-trans isomerization of cyclophilin involved in HIV-1 infectivity?

Kinetic analysis of the unfolding and refolding of ribonuclease T1 by a stopped-flow double-mixing technique

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Major histocompatibility complex class II molecule-human immunodeficiency virus peptide analysis using a microarray chip

Mapping the stereospecificity of peptidyl prolyl cis/trans isomerases

Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2.

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries

New assays and approaches for discovery and design of Sirtuin modulators

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

P143-M Microarray-Generated Phosphopeptide Selectivity Profiles for Fluorescent Conjugates of an Artificial Phosphomonoester-Binding Small Molecule; Implications for the Global Enrichment and Detection of Phosphopeptides and Phosphoproteins.

PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation

Parvulin 17 promotes microtubule assembly by its peptidyl-prolyl cis/trans isomerase activity

Pattern recognition in pulmonary tuberculosis defined by high content peptide microarray chip analysis representing 61 proteins from M. tuberculosis

Peptide Arrays in Proteomics and Drug Discovery

Peptide Arrays on Solid Supports: A Tool for the Identification of Peptide Ligands

Peptide Microarrays for Profiling of Epigenetic Targets

Peptide arrays for enzyme profiling

Peptide arrays for kinase profiling

Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46

Peptide microarrays for profiling of modification state-specific antibodies

Potent and Selective Inhibitors of Human Sirtuin 5.

Probing Substrate Backbone Function in Prolyl Oligopeptidase Catalysis. Large Positional Effects of Peptide Bond Monothioxylation

Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease.

Profiling of generic anti-phosphopeptide antibodies and kinases with peptide microarrays using radioactive and fluorescence-based assays

Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition†

Rotational Barriers ofcis/transIsomerization of Proline Analogues and Their Catalysis by Cyclophilin§

SIRT5 regulation of ammonia-induced autophagy and mitophagy

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Separation of cis/trans isomers of a prolyl peptide bond by capillary zone electrophoresis.

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

Serotyping of Toxoplasma gondii in cats (Felis domesticus) reveals predominance of type II infections in Germany

Side-chain effects on peptidyl-prolyl cis/trans isomerisation.

Sirt1 activation by resveratrol is substrate sequence-selective

Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition

Solid-phase synthesis of peptide-4-nitroanilides

SpikeTides™—proteotypic peptides for large-scale MS-based proteomics