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List of works by Albert M Berghuis

A recurrent PDGFRB mutation causes familial infantile myofibromatosis

scientific article published on 23 May 2013

A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni

scientific article

An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.

scientific article

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia

scientific article

Biophysics in Canada

scientific article published in November 2017

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

scientific article published on 30 January 2011

Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme

scientific article published on 22 June 2016

Crystal Structures of Two Aminoglycoside Kinases Bound with a Eukaryotic Protein Kinase Inhibitor

scientific article

Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism

scientific article

Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases

scientific article published on 10 March 2004

Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases

scientific article

Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose

scientific article

Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases

scientific article

Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor

scientific article

Crystallization and Preliminary Crystallographic Studies of Giα1 and Mutants of Giα1 in the GTP and GDP-bound States

scientific article published on 01 May 1994

Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae

scientific article published on 01 May 1998

Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7.

scientific article published on 23 September 2004

Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila

scientific article

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase

scientific article published on 16 October 2017

Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase

scientific article

Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells

scientific article

Effect of solvent and protein dynamics in ligand recognition and inhibition of aminoglycoside adenyltransferase 2″-Ia

scientific article

Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment

scientific article published on April 5, 1992

Enzyme-Assisted Suicide

article published in 2003

Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity

scientific article

Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO

scientific article

Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation

scientific journal article

Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma

scientific article published on 23 June 2017

Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein

scientific article

Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors

scientific article published on 26 February 2016

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

scientific article published on 20 November 2020

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.

scientific article published on 18 January 2017

Human isoprenoid synthase enzymes as therapeutic targets

scientific article

IRF8 mutations and human dendritic-cell immunodeficiency

scientific article

Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence

scientific article published on 27 September 2006

Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication

scientific article published on 14 November 2013

Inhibition of outer membrane proteases of the omptin family by aprotinin

scientific article published on 30 March 2015

Isolation, Crystallization and Preliminary Diffraction Analyses of Human Pancreatic α-Amylase

scientific article published on 01 April 1993

LG-26GERMLINE AND SOMATIC FGFR1 ABNORMALITIES IN DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS.

scientific article published on 30 May 2016

Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis

scientific article

Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography ⬇️

scientific article published on February 6, 1992

Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase

scientific article

Maintenance of native-like protein dynamics may not be required for engineering functional proteins

scientific article

Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop

scientific article (publication date: 4 June 2002)

Multiple Conformers in Active Site of Human Dihydrofolate Reductase F31R/Q35E Double Mutant Suggest Structural Basis for Methotrexate Resistance

scientific article

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases

scientific article

Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment

scientific article

New phenolic inhibitors of yeast homoserine dehydrogenase

scientific article

Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure

scientific article

Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides.

scientific article

Oxidation state-dependent conformational changes in cytochrome c

scientific article published on February 20, 1992

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase

scientific article published on 16 February 2017

Plasticity of aminoglycoside binding to antibiotic kinase APH(2")-Ia.

scientific article published on 16 April 2018

Preparation and characterization of bacterial protein complexes for structural analysis

scientific article

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase

scientific article

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

scientific article published on 25 June 2013

Protein kinase inhibitors and antibiotic resistance

scientific article

Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate

scientific article

Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases

scientific article published on 01 October 2005

Small-Angle X-Ray Scattering Analysis of the Bifunctional Antibiotic Resistance Enzyme Aminoglycoside (6′) Acetyltransferase-Ie/Aminoglycoside (2″) Phosphotransferase-Ia Reveals a Rigid Solution Structure ⬇️

scientific article published on January 30, 2012

Structural Analysis of the Tobramycin and Gentamicin Clinical Resistome Reveals Limitations for Next-generation Aminoglycoside Design

scientific article

Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

scientific article

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance

scientific article published in April 2017

Structural Basis of APH(3')-IIIa-Mediated Resistance to N1-Substituted Aminoglycoside Antibiotics

scientific article

Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A

scientific article

Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase

scientific article

Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b

scientific article

Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity

scientific article

Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae

scientific article

Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate

scientific article

Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila

scientific article

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold ⬇️

scientific article published on March 24, 1995

Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses.

scientific article

Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry

scientific article

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme

scientific article published on 14 September 2014

Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases

scientific article published on 01 August 2006

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

scientific article

The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance

scientific article published in Journal of Biological Chemistry

The Substrate-Bound Crystal Structure of a Baeyer–Villiger Monooxygenase Exhibits a Criegee-like Conformation

scientific article

The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c

scientific article

The role of a conserved water molecule in the redox-dependent thermal stability of iso-1-cytochrome c.

scientific article published in November 1996

The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure

scientific article

The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation

scientific article published on June 2008

Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition

scientific article

Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP.

scientific article published on July 2005

X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members

scientific article (publication date: March 2003)

YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics

scientific article

ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

scientific article published on 22 January 2020

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