List of works - David Harrison

5-hydroxymethylcytosine profiling as an indicator of cellular state

scientific article published on December 2013

A cautionary lesson on the use of targeted methods for EGFR mutation analysis: a case report.

scientific article

A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

scientific article

A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.

scientific article published on 6 February 2007

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen.

scientific article

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells.

scientific article published on 04 October 2016

A principled machine learning framework improves accuracy of stage II colorectal cancer prognosis

scientific article published on 02 October 2018

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT.

scientific article

Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes.

scientific article

Adenovirus-mediated Cre deletion of floxed sequences in primary mouse cells is an efficient alternative for studies of gene deletion.

scientific article published on August 2001

Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models.

scientific article published on 31 March 2016

Apoptosis and DNA methylation.

scientific article published on April 2011

Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans

scientific article

Automated Analysis of Lymphocytic Infiltration, Tumor Budding, and Their Spatial Relationship Improves Prognostic Accuracy in Colorectal Cancer

scientific article published on 07 March 2019

Automated tumour budding quantification by machine learning augments TNM staging in muscle-invasive bladder cancer prognosis

scientific article published on 26 March 2019

C35 overexpression defines subsets of human breast cancer and its immunoreceptor tyrosine-based activation motif represents a novel treatment target.

scientific article published on 13 May 2008

C4d immunopositivity is uncommon in ABO-compatible liver allografts, but correlates partially with lymphocytotoxic antibody status

scientific article published on 01 May 2007

Carbonic anhydrase 9 expression increases with vascular endothelial growth factor-targeted therapy and is predictive of outcome in metastatic clear cell renal cancer.

scientific article published on 10 May 2014

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model.

scientific article

Chemical analysis of multicellular tumour spheroids.

scientific article published on 29 April 2015

Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer

scientific article

Clinical utility of an epigenetic assay to detect occult prostate cancer in histopathologically negative biopsies: results of the MATLOC study

scientific article published on 08 October 2012

Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model

scientific article published on 28 February 2022

Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition.

scientific article published on 14 October 2010

Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation.

scientific article

Could molecular pathology testing in lung cancer be more cost-effective?

scientific article published on 7 July 2016

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations.

scientific article published on 5 February 2014

Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer.

scientific article

Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture ⬇️

scientific article published on November 1, 2011

Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome

scientific article

Diversity of matriptase expression level and function in breast cancer.

scientific article

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

scientific article

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer

scientific article published on 23 March 2016

Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models

scientific article

E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells.

scientific article published on 18 December 2006

Effect of glandular metastases on overall survival of patients with metastatic clear cell renal cell carcinoma in the antiangiogenic therapy era.

scientific article published on 3 December 2015

Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).

scientific article published on 27 November 2007

Epigenetic sampling effects: nephrectomy modifies the clear cell renal cell cancer methylome.

scientific article

Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

scientific article published on 10 December 2019

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

scientific article published on 13 December 2017

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

scientific article published on 4 October 2011

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.

scientific article

Gene therapy for chronic obstructive pulmonary disease: twilight or triumph?

scientific article

Genetic and epigenetic analyses of MBD3 in colon and lung cancer.

scientific article published on May 2004

Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

scientific article published on 21 May 2019

Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo.

scientific article

HER2 expression in ovarian carcinoma: caution and complexity in biomarker analysis

scientific article published on 12 March 2012

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence ⬇️

scientific article published on October 25, 2011

Human tissue in systems medicine.

scientific article published on 29 October 2013

Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

scientific article published on 28 November 2018

Increased STAT1 signaling in endocrine-resistant breast cancer

scientific article

Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells.

scientific article published in July 2010

Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells.

scientific article

Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002.

scientific article

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

scientific article

Long-term culture of human breast cancer specimens and their analysis using optical projection tomography.

scientific article

MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.

scientific article

MBD4 interacts with and recruits USP7 to heterochromatic foci

scientific article

Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry.

scientific article

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver

scientific article published on April 2005

Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network

scientific article

Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity.

scientific article

Molecular pathology in therapeutics: where are we now, and where are we going?

scientific article

Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers

scientific article published on 17 December 2015

Multidisciplinary urological engagement in translational renal cancer research

scientific article published on 28 July 2014

New strategies for targeting the hypoxic tumour microenvironment in breast cancer

scientific article published on 12 October 2012

Novel Internationally Verified Method Reports Desmoplastic Reaction as the Most Significant Prognostic Feature For Disease-specific Survival in Stage II Colorectal Cancer

scientific article published on 01 September 2019

Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis

scientific article

Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer.

scientific article

Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting.

scientific article published on 15 June 2016

Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer

scientific article published on 26 June 2017

Pertuzumab for the treatment of ovarian cancer.

scientific article published on July 2010

Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy.

scientific article published on 18 February 2011

Podocyte injury elicits loss and recovery of cellular forces.

scientific article

Predicting response to the anti-estrogen fulvestrant in recurrent ovarian cancer.

scientific article published on 30 July 2013

Prognostic relevance of DNA copy number changes in colorectal cancer.

scientific article published in February 2010

Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

scientific article

Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells.

scientific article

Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases.

scientific article published on 25 October 2009

Raman spectroscopy investigation of biochemical changes in tumour spheroids with ageing and after treatment with staurosporine

scientific article published on 09 January 2019

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

scientific article published on 8 June 2015

Reply to: Discordant expression of molecular markers between primary and nodal metastases: a histopathological manifestation of the 'self (stem cell)-seeding' nature of breast cancer disease?

scientific article published on 09 March 2010

Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies

scientific article published on 28 April 2016

Routinely obtained diagnostic material as a source of RNA for personalized medicine in lung cancer patients.

scientific article

Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

scientific article

Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme ⬇️

article

Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.

scientific article published on 15 February 2013

Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy

scientific article

Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer.

scientific article published on 26 May 2015

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy.

scientific article published on 10 June 2014

Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

scientific article published on 28 July 2009

TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status.

scientific article

TMA Navigator: Network inference, patient stratification and survival analysis with tissue microarray data

scientific article

Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids.

scientific article published in September 2016

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

scientific article

The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro

scientific article published on 07 April 2020

The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.

scientific article published on 4 November 2005

The Molecular Biology of Renal Cancer: Another Piece of the Puzzle

scientific article published on 14 March 2014

The development of prognostic and predictive biomarkers in renal cell cancer are not one and the same thing.

scientific article

The effect of VEGF-targeted therapy on biomarker expression in sequential tissue from patients with metastatic clear cell renal cancer.

scientific article

The importance of growth factors and steroid hormones in ovarian cancer

scientific article published on 16 October 2009

The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome

scientific article published on 06 August 2019

The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer

scientific article published on 14 December 2015

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.

scientific article published on 31 December 2007

The use of reverse phase protein arrays (RPPA) to explore protein expression variation within individual renal cell cancers.

scientific article published on 22 January 2013

Tissue Proteomic Analysis Identifies Mechanisms and Stages of Immunopathology in Fatal COVID-19

scientific article published on 01 February 2022

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

scientific article

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

scientific article

Total synthesis of dehaloperophoramidine using a highly diastereoselective Hosomi-Sakurai reaction

scientific article published on 10 August 2016

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

scientific article

Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer.

scientific article published on 30 April 2015

Transplant histopathology for the general histopathologist.

scientific article published on October 2003

Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies.

scientific article published on 13 May 2011

Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells.

scientific article published on 26 December 2007

Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer

scientific article published on 26 July 2011

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

scientific article published on 21 September 2010

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.

scientific article

Use of microarray analysis to investigate EMT gene signatures

scientific article published on January 2013

Utilizing mRNA extracted from small, archival formalin-fixed paraffin-embedded prostate samples for translational research: assessment of the effect of increasing sample age and storage temperature.

scientific article published on 30 March 2011

WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies

scientific article published on 19 August 2018

WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

scientific article

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

scientific article

YAP Translocation Precedes Cytoskeletal Rearrangement in Podocyte Stress Response: A Podometric Investigation of Diabetic Nephropathy

scientific article published on 15 July 2021

List of works by David Harrison

5-hydroxymethylcytosine profiling as an indicator of cellular state

A cautionary lesson on the use of targeted methods for EGFR mutation analysis: a case report.

A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen.

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells.

A principled machine learning framework improves accuracy of stage II colorectal cancer prognosis

A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT.

Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes.

Adenovirus-mediated Cre deletion of floxed sequences in primary mouse cells is an efficient alternative for studies of gene deletion.

Antitumour activity of the novel flavonoid Oncamex in preclinical breast cancer models.

Apoptosis and DNA methylation.

Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans

Automated Analysis of Lymphocytic Infiltration, Tumor Budding, and Their Spatial Relationship Improves Prognostic Accuracy in Colorectal Cancer

Automated tumour budding quantification by machine learning augments TNM staging in muscle-invasive bladder cancer prognosis

C35 overexpression defines subsets of human breast cancer and its immunoreceptor tyrosine-based activation motif represents a novel treatment target.

C4d immunopositivity is uncommon in ABO-compatible liver allografts, but correlates partially with lymphocytotoxic antibody status

Carbonic anhydrase 9 expression increases with vascular endothelial growth factor-targeted therapy and is predictive of outcome in metastatic clear cell renal cancer.

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model.

Chemical analysis of multicellular tumour spheroids.

Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer

Clinical utility of an epigenetic assay to detect occult prostate cancer in histopathologically negative biopsies: results of the MATLOC study

Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model

Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition.

Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation.

Could molecular pathology testing in lung cancer be more cost-effective?

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations.

Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer.

Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture ⬇️

Differential expression of prognostic proteomic markers in primary tumour, venous tumour thrombus and metastatic renal cell cancer tissue and correlation with patient outcome

Diversity of matriptase expression level and function in breast cancer.

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer

Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models

E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells.

Effect of glandular metastases on overall survival of patients with metastatic clear cell renal cell carcinoma in the antiangiogenic therapy era.

Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).

Epigenetic sampling effects: nephrectomy modifies the clear cell renal cell cancer methylome.

Evaluation of the dual mTOR/PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.

Gene therapy for chronic obstructive pulmonary disease: twilight or triumph?

Genetic and epigenetic analyses of MBD3 in colon and lung cancer.

Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031

Gonadotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo.

HER2 expression in ovarian carcinoma: caution and complexity in biomarker analysis

Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence ⬇️

Human tissue in systems medicine.

Identifying prognostic structural features in tissue sections of colon cancer patients using point pattern analysis

Increased STAT1 signaling in endocrine-resistant breast cancer

Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells.

Inhibition of pH regulation as a therapeutic strategy in hypoxic human breast cancer cells.

Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002.

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

Long-term culture of human breast cancer specimens and their analysis using optical projection tomography.

MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.

MBD4 interacts with and recruits USP7 to heterochromatic foci

Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry.

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver

Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network

Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity.

Molecular pathology in therapeutics: where are we now, and where are we going?

Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers

Multidisciplinary urological engagement in translational renal cancer research

New strategies for targeting the hypoxic tumour microenvironment in breast cancer

Novel Internationally Verified Method Reports Desmoplastic Reaction as the Most Significant Prognostic Feature For Disease-specific Survival in Stage II Colorectal Cancer

Novel Monte Carlo approach quantifies data assemblage utility and reveals power of integrating molecular and clinical information for cancer prognosis

Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer.

Novel histopathologic feature identified through image analysis augments stage II colorectal cancer clinical reporting.

Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer

Pertuzumab for the treatment of ovarian cancer.

Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy.

Podocyte injury elicits loss and recovery of cellular forces.

Predicting response to the anti-estrogen fulvestrant in recurrent ovarian cancer.

Prognostic relevance of DNA copy number changes in colorectal cancer.

Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells.

Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases.