List of works - Nobuyuki Takahashi

Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism.

scientific article published on August 2003

Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.

scientific article published on 2 April 2011

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes

scientific article (publication date: 26 March 2004)

Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation.

scientific article published on 14 March 2013

Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes.

scientific article published on January 2008

Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice

scientific article published on 21 November 2012

Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation.

scientific article published on 3 November 2009

Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats

scientific article published on 23 March 2006

Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.

scientific article published on August 2004

Chloride channel inhibition prevents ROS-dependent apoptosis induced by ischemia-reperfusion in mouse cardiomyocytes.

scientific article

ClC-3-independent sensitivity of apoptosis to Cl- channel blockers in mouse cardiomyocytes

scientific article published in January 2005

Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes

scientific article

DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells.

scientific article published on 16 October 2013

Dehydroabietic acid activates peroxisome proliferator-activated receptor-γ and stimulates insulin-dependent glucose uptake into 3T3-L1 adipocytes.

scientific article published on July 2011

Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.

scientific article published in September 2009

Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein

scientific article published on 07 February 2011

Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice.

scientific article

Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice.

scientific article published on 24 November 2010

Dysfunction of regulatory volume increase is a key component of apoptosis

scientific article published on 09 November 2006

Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin.

scientific article published in January 2013

Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.

scientific article published on 23 August 2011

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

scientific article published on August 2011

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells.

scientific article published on July 2006

Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

scientific article published on 25 May 2010

Genome science of lipid metabolism and obesity.

scientific article published on 07 April 2009

Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.

scientific article published on 9 January 2013

Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes

scientific journal article

Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation.

scientific article published on 23 October 2009

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.

scientific article

Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

scientific article

Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans.

scientific article published on 4 September 2013

Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice

scientific article (publication date: 2012)

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.

scientific article published on 3 February 2010

Signalling events employed in the hypertonic activation of cation channels in HeLa cells

scientific article published on 01 January 2007

Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.

scientific article

Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.

scientific article published on 12 August 2013

The structures and functions of peroxisome proliferator-activated receptors (PPARs)

scientific article published in April 2005

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

scientific article published in September 2011

Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

scientific article published on 09 November 2011

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism.

scientific article published on 3 June 2010

Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.

scientific article published on 27 January 2010

[Regulatory mechanisms for the control of the adipocyte life cycle].

scientific article published in January 2011

List of works by Nobuyuki Takahashi

Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism.

Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes

Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation.

Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes.

Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice

Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation.

Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats

Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.

Chloride channel inhibition prevents ROS-dependent apoptosis induced by ischemia-reperfusion in mouse cardiomyocytes.

ClC-3-independent sensitivity of apoptosis to Cl- channel blockers in mouse cardiomyocytes

Comprehensive analysis of the ascidian genome reveals novel insights into the molecular evolution of ion channel genes

DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells.

Dehydroabietic acid activates peroxisome proliferator-activated receptor-γ and stimulates insulin-dependent glucose uptake into 3T3-L1 adipocytes.

Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice.

Development of a novel PPARγ ligand screening system using pinpoint fluorescence-probed protein

Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator-activated receptor-α (PPAR-α) activation in diabetic obese mice.

Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice.

Dysfunction of regulatory volume increase is a key component of apoptosis

Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin.

Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.

Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.

Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells.

Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

Genome science of lipid metabolism and obesity.

Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes.

Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes

Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation.

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.

Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans.

Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice

Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo.

Signalling events employed in the hypertonic activation of cation channels in HeLa cells

Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice.

Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.

The structures and functions of peroxisome proliferator-activated receptors (PPARs)

Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice.

Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism.

Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.

[Regulatory mechanisms for the control of the adipocyte life cycle].