List of works - Adam Yasgar

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth

scientific article

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

scientific article

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

scientific article

A Homogeneous Platform to Discover Inhibitors of the GoLoco Motif/G-alpha Interaction

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

scientific article

A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding

scientific article

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

scientific article

A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity

scientific article

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

scientific article published on 18 January 2022

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

scientific article

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions

scientific article

Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase

scientific article

Compound Management for Quantitative High-Throughput Screening

scientific article

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

scientific article published on 15 May 2018

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

scientific article published on 8 November 2016

Current approaches for the discovery of drugs that deter substance and drug abuse

scientific article

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

scientific article published on 27 February 2018

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

scientific article published on 24 July 2015

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

scientific article published on 16 May 2018

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

scientific article

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

scientific article

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

scientific article published on 25 April 2006

Fluorescence polarization assays in high-throughput screening and drug discovery: a review

scientific article published on 28 April 2016

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

scientific article

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding

scientific article

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

scientific article

High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe

scientific article

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models

scientific article published on 25 October 2019

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold

scientific article published on 21 August 2017

Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor

scientific article published on 10 June 2013

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies

scientific article

Preparation of FRET reporters to support chemical probe development

scientific article published on 20 August 2010

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

scientific article published on 16 November 2017

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

scientific article

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

scientific article

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

scientific journal article

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors

scientific article published on 04 December 2013

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

scientific article published on 06 January 2014

Testing for drug-human serum albumin binding using fluorescent probes and other methods

scientific article published on 15 October 2018

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

scientific article

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

scientific article published on 03 November 2020

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors

scientific article published on 23 November 2020

List of works by Adam Yasgar

4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

A Homogeneous Platform to Discover Inhibitors of the GoLoco Motif/G-alpha Interaction

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions

Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase

Compound Management for Quantitative High-Throughput Screening

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Current approaches for the discovery of drugs that deter substance and drug abuse

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

Fluorescence polarization assays in high-throughput screening and drug discovery: a review

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probe

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold

Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor

Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies

Preparation of FRET reporters to support chemical probe development

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors

Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase

Testing for drug-human serum albumin binding using fluorescent probes and other methods

The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors