Search filters

List of works by Miloš Hroch

677TT genotype is associated with elevated risk of methotrexate (MTX) toxicity in juvenile idiopathic arthritis: treatment outcome, erythrocyte concentrations of MTX and folates, and MTHFR polymorphisms.

scientific article published in July 2010

Alteration of Methotrexate Biliary and Renal Elimination during Extrahepatic and Intrahepatic Cholestasis in Rats

scientific article published on 01 December 2009

Amiodarone modulates pharmacokinetics of low-dose methotrexate in rats.

scientific article published in July 2008

An improved high-performance liquid chromatography method for quantification of methotrexate polyglutamates in red blood cells of children with juvenile idiopathic arthritis.

scientific article

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

scientific article

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

scientific article published on 2 November 2016

Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis

scientific article published on 16 June 2021

Boldine Inhibits Mouse Mammary Carcinoma In Vivo and Human MCF-7 Breast Cancer Cells In Vitro.

scientific article published on 9 September 2016

Boldine attenuates cholestasis associated with nonalcoholic fatty liver disease in hereditary hypertriglyceridemic rats fed by high-sucrose diet

scientific article published in January 2015

Boldine enhances bile production in rats via osmotic and farnesoid X receptor dependent mechanisms

scientific article published on 12 March 2015

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane

scientific article published on 23 December 2015

Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.

scientific article

Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways.

scientific article

Comparative pharmacokinetics of N(ω)-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats.

scientific article published on 21 March 2013

Comparison of protective effects of two iron chelating compounds – deferiprone and dexrazoxane – against chronic anthracycline cardiotoxicity

Deferiprone does not protect against chronic anthracycline cardiotoxicity in vivo.

scientific article

Deferoxamine but not Dexrazoxane Alleviates Liver Injury Induced by Endotoxemia in Rats

scientific article published on 01 October 2014

Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC-MS/MS

scientific article published on 24 July 2013

Dexamethasone reduces methotrexate biliary elimination and potentiates its hepatotoxicity in rats

scientific article published on 14 November 2009

Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death

scientific article published on 21 July 2009

Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits.

scientific article published on 4 July 2013

Erratum to: Kinetically Guided Neoadjuvant Chemoradiotherapy Based on 5-Fluorouracil in Patients with Locally Advanced Rectal Cancer

scientific article published on 01 April 2015

HPLC determination of arginases inhibitor N-(ω)-hydroxy-nor-L-arginine using core-shell particle column and LC-MS/MS identification of principal metabolite in rat plasma

scientific article published on 20 November 2011

High soluble endoglin levels regulate cholesterol homeostasis and bile acids turnover in the liver of transgenic mice

scientific article published on 09 July 2019

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats

scientific article published on 10 December 2014

In vivo study of radioprotective effect of NO-synthase inhibitors and acetyl-L-carnitine

article published in 2013

Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study

scientific article published on 18 December 2019

Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

scientific article published on 6 September 2017

Iron overload reduces synthesis and elimination of bile acids in rat liver

scientific article published on 05 July 2019

Kinetically guided neoadjuvant chemoradiotherapy based on 5-Fluorouracil in patients with locally advanced rectal cancer

scientific article published on 01 May 2015

LC-MS/MS method for the determination of haemanthamine in rat plasma, bile and urine and its application to a pilot pharmacokinetic study.

scientific article published on 17 November 2015

MTHFR polymorphism and red cell folate levels are not useful as biomarkers of methotrexate efficacy and toxicity in children with juvenile idiopathic arthritis.

scientific article published on 15 September 2008

Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase.

scientific article published on 11 February 2009

P-glycoprotein function and expression during obstructive cholestasis in rats

Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma.

scientific article published on 30 June 2011

Pharmacokinetics of boldine in control and Mrp2-deficient rats.

scientific article published in December 2016

Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

scientific article published in November 2017

Single- and multiple-dose pharmacokinetics of arginase inhibitor Nω-hydroxy-nor-L-arginine, and its effect on plasma amino acids concentrations in Wistar rats.

scientific article

Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity

scientific article published on 8 December 2015

Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease ⬇️

scientific article published on August 24, 2010

Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats

scientific article published on 01 July 2019

The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats.

scientific article published on 25 October 2017

The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction.

scientific article published on 02 October 2013

The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis.

scientific article published on 29 December 2007

The effect of rat strain, diet composition and feeding period on the development of a nutritional model of non-alcoholic fatty liver disease in rats

scientific article published on 29 November 2010

Up-regulation of renal Mdr1 and Mrp2 transporters during amiodarone pretreatment in rats.

scientific article published on 22 August 2009

Paulina is supported by:

About Paulina

Help