List of works - Weiqiang Lu

2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation

scientific article published on 16 February 2009

2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors.

scientific article published on 2 September 2016

2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies.

scientific article published on 21 January 2009

A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling

scientific article published on 06 June 2019

A genome-wide positioning systems network algorithm for in silico drug repurposing

scientific article published on 02 August 2019

A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging

scientific article published on 17 June 2011

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

scientific article published on 08 March 2022

Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity.

scientific article published on 20 April 2013

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis

scientific article published on 26 December 2019

Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibit Plasmodium Falciparum Dihydroorotate Dehydrogenase

scientific article published on 27 March 2018

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent

scientific article published on 9 December 2011

Design, synthesis, and biological evaluations of phenylpropiolic acid derivatives as novel GPR40 agonists

scientific article published on 31 August 2018

Development of a new colorimetric assay for lipoxygenase activity.

scientific article published on 26 June 2013

Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

scientific article published on 25 January 2014

Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy

scientific article published on 02 January 2020

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening

scientific article published on 28 September 2012

Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening

scientific article published on 29 April 2013

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

scientific article published on 20 February 2017

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

scientific article

From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis

scientific article published on 31 December 2020

HL005--a new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7.

scientific article

Identification of inhibitors against p90 ribosomal S6 kinase 2 (RSK2) through structure-based virtual screening with the inhibitor-constrained refined homology model.

scientific article

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

scientific article published in August 2009

Identification of old drugs as potential inhibitors of HIV-1 integrase – human LEDGF/p75 interaction via molecular docking ⬇️

scientific article published on June 26, 2012

In silico prediction of chemical mechanism of action via an improved network-based inference method

scientific article published on 20 September 2016

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder.

scientific article published on 09 June 2016

Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo

scientific article published on 27 July 2017

Luciferase reporter gene assay on human 5-HT receptor: which response element should be chosen?

scientific article

Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages ⬇️

scientific article published on 25 July 2016

Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity.

scientific article published on July 2016

Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress

scientific article published on 19 May 2020

Natural products as a gold mine for selective matrix metalloproteinases inhibitors.

scientific article

Prediction of drug-target interactions and drug repositioning via network-based inference

scientific article

Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

scientific article

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches.

scientific article published on 10 November 2017

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

scientific article published on 07 December 2020

SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.

scientific article published on 22 April 2011

Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models

scientific article published on 01 November 2019

Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway

scientific article published on 10 October 2014

Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel

scientific article published on 16 January 2019

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

scientific article (publication date: 19 May 2016)

Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives.

scientific article published on 30 May 2011

Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).

scientific article

Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors.

scientific article published on 30 April 2012

Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors.

scientific article published on 21 March 2012

The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer

scientific article

The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.

scientific article published on 23 April 2012

Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A.

scientific article published on October 2014

Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity

scientific article published on 12 March 2019

β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1- and Oxidative Stress-Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis

scientific article published on 05 April 2016

List of works by Weiqiang Lu

2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio) acetamides as a new class of falcipain-2 inhibitors. 3. design, synthesis and biological evaluation

2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors.

2-amido-3-(1H-indol-3-yl)-N-substituted-propanamides as a new class of falcipain-2 inhibitors. 1. Design, synthesis, biological evaluation and binding model studies.

A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling

A genome-wide positioning systems network algorithm for in silico drug repurposing

A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity.

Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis

Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibit Plasmodium Falciparum Dihydroorotate Dehydrogenase

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent

Design, synthesis, and biological evaluations of phenylpropiolic acid derivatives as novel GPR40 agonists

Development of a new colorimetric assay for lipoxygenase activity.

Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening

Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening

Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis.

FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis

HL005--a new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7.

Identification of inhibitors against p90 ribosomal S6 kinase 2 (RSK2) through structure-based virtual screening with the inhibitor-constrained refined homology model.

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Identification of old drugs as potential inhibitors of HIV-1 integrase – human LEDGF/p75 interaction via molecular docking ⬇️

In silico prediction of chemical mechanism of action via an improved network-based inference method

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder.

Inhibition of histone deacetylases sensitizes EGF receptor-TK inhibitor-resistant non-small-cell lung cancer cells to erlotinib in vitro and in vivo

Luciferase reporter gene assay on human 5-HT receptor: which response element should be chosen?

Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages ⬇️

Myricetin is a novel inhibitor of human inosine 5'-monophosphate dehydrogenase with anti-leukemia activity.

Natural product corynoline suppresses melanoma cell growth through inducing oxidative stress

Natural products as a gold mine for selective matrix metalloproteinases inhibitors.

Prediction of drug-target interactions and drug repositioning via network-based inference

Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches.

Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer

SHAFTS: a hybrid approach for 3D molecular similarity calculation. 2. Prospective case study in the discovery of diverse p90 ribosomal S6 protein kinase 2 inhibitors to suppress cell migration.

Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models

Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway

Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Synthesis and antimalarial activity of novel dihydro-artemisinin derivatives.

Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).

Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors.

Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors.

The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer

The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.

Total synthesis and biological studies of cryptocin and derivatives of equisetin and fusarisetin A.

Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity

β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1- and Oxidative Stress-Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis