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List of works by Patrick Scheerer

A G protein-coupled receptor at work: the rhodopsin model.

scientific article published on 21 October 2009

A Prokaryotic (6-4) Photolyase with a DMRL Chromophore and an Iron-Sulfur Cluster

A coleopteran triosephosphate isomerase: X-ray structure and phylogenetic impact of insect sequences

scientific article

A ligand channel through the G protein coupled receptor opsin

scientific article

A new multi-system disorder caused by the Gαs mutation p.F376V

article

A protonation-coupled feedback mechanism controls the signalling process in bathy phytochromes

scientific article published on 13 April 2015

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation

article published in 2018

Assembly of synthetic locked chromophores with agrobacterium phytochromes Agp1 and Agp2.

scientific article published on 27 June 2006

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor.

scientific article

Chromophore Heterogeneity and Photoconversion in Phytochrome Crystals and Solution Studied by Resonance Raman Spectroscopy

scholarly article by David von Stetten et al published 9 June 2008 in Angewandte Chemie International Edition

Chromophore structure of cyanobacterial phytochrome Cph1 in the Pr state: reconciling structural and spectroscopic data by QM/MM calculations

scientific article

Common Structural Elements in the Chromophore Binding Pocket of the Pfr State of Bathy Phytochromes

scientific article published in May 2017

Conformational Dynamics During GPCR - G Protein Coupling

article published in 2014

Conserved Tyr223(5.58) plays different roles in the activation and G-protein interaction of rhodopsin.

scientific article published on 20 April 2011

Crystal Structures of Bacterial (6-4) Photolyase Mutants with Impaired DNA Repair Activity.

scientific article

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

scholarly article by Astrid Borchert published in September 2018

Crystal structure of C-terminally truncated arrestin reveals mechanism of arrestin activation

Crystal structure of Dynein Light Chain 8a (DLC8) from Toxoplasma gondii at 1.5 A resolution

Crystal structure of a common GPCR-binding interface for G protein and arrestin

scientific article published on 10 September 2014

Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore

scientific article

Crystal structure of metarhodopsin II

scientific article

Crystal structure of opsin in its G-protein-interacting conformation

scientific article

Crystal structure of pre-activated arrestin p44

scientific article

Crystal structure of the ligand-free G-protein-coupled receptor opsin

scientific article

Crystallization and preliminary X-ray crystallographic analysis of the N-terminal photosensory module of phytochrome Agp1, a biliverdin-binding photoreceptor from Agrobacterium tumefaciens

scientific article published in December 2005

Crystallization and preliminary X-ray crystallographic analysis of the [NiFe]-hydrogenase maturation factor HypF1 from Ralstonia eutropha H16

scientific article

Crystallization and preliminary X-ray studies of mouse centrin1

scientific article

Crystallization and preliminary x-ray analysis of complexes of porcine pancreatic elastase with two natural inhibitors

scientific article

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin

scientific article published on 19 March 2019

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

scientific article published on 12 February 2020

Divalent Cations Increase DNA Repair Activities of Bacterial (6-4) Photolyases

scientific article published on 19 December 2016

Double-flow focused liquid injector for efficient serial femtosecond crystallography

scientific article published on 16 March 2017

Dynein light chain 8a of Toxoplasma gondii, a unique conoid-localized β-strand-swapped homodimer, is required for an efficient parasite growth

scientific article

Effect of channel mutations on the uptake and release of the retinal ligand in opsin.

scientific article published on 19 March 2012

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes

scientific article published on 19 February 2019

Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring

scientific article published on 25 June 2021

Highly conserved residues Asp-197 and His-250 in Agp1 phytochrome control the proton affinity of the chromophore and Pfr formation.

scientific article published on 22 November 2006

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83.

scientific article

Insights into functional aspects of centrins from the structure of N-terminally extended mouse centrin 1.

scientific article published on 6 October 2006

Intersubunit distances in full-length, dimeric, bacterial phytochrome Agp1, as measured by pulsed electron-electron double resonance (PELDOR) between different spin label positions, remain unchanged upon photoconversion

scientific article

Intramolecular Proton Transfer Controls Protein Structural Changes in Phytochrome

scientific article published on 28 February 2020

Key Amino Acids in the Bacterial (6-4) Photolyase PhrB from Agrobacterium fabrum

scientific article published on 21 October 2015

Krypton Derivatization of an O2 -Tolerant Membrane-Bound [NiFe] Hydrogenase Reveals a Hydrophobic Tunnel Network for Gas Transport

scientific article

Light-induced activation of bacterial phytochrome Agp1 monitored by static and time-resolved FTIR spectroscopy

scientific article published in April 2010

Light-induced conformational changes of the chromophore and the protein in phytochromes: bacterial phytochromes as model systems.

scientific article published on April 2010

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6.

scientific article published on 8 January 2018

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor

scientific article published on 06 December 2018

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

scientific article published on 27 November 2021

Molecular architecture of the ribosome-bound Hepatitis C Virus internal ribosomal entry site RNA.

scientific article published on 24 November 2015

Molecular basis for the catalytic inactivity of a naturally occurring near-null variant of human ALOX15.

scientific article published on 16 August 2013

Phytochromes from Agrobacterium fabrum

scientific article

Position of transmembrane helix 6 determines receptor G protein coupling specificity

scientific article

Protein structures guide the design of a much-needed tool for neuroscience

scientific article published in Nature

Recurrent convergent evolution at amino acid residue 261 in fish rhodopsin

scientific article published on 26 August 2019

Resonance Raman Spectroscopic Analysis of the [NiFe] Active Site and the Proximal [4Fe-3S] Cluster of an O2-Tolerant Membrane-Bound Hydrogenase in the Crystalline State

article

Reversible [4Fe-3S] cluster morphing in an O(2)-tolerant [NiFe] hydrogenase

scientific article

Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction

scientific article published on 25 November 2015

Role of the Propionic Side Chains for the Photoconversion of Bacterial Phytochromes

scientific article published on 06 August 2019

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

scientific article published on 31 July 2019

Structural Basis for Two-component System Inhibition and Pilus Sensing by the Auxiliary CpxP Protein

scientific article

Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor

scientific article published on 10 August 2020

Structural and functional basis of phospholipid oxygenase activity of bacterial lipoxygenase from Pseudomonas aeruginosa

scientific article

Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface

scholarly article

Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)

scientific article

Structural mechanism of arrestin activation

scientific article published on 07 June 2017

Structural snapshot of a bacterial phytochrome in its functional intermediate state

scientific article published in Nature Communications

Structural snapshots of actively translating human ribosomes

scientific article published on May 2015

Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

scientific article

Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition

scientific article

Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading (30S subunit)

Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading (50S subunit)

Structure of the biliverdin cofactor in the Pfr state of bathy and prototypical phytochromes

scientific article published on 19 April 2013

Structure-based biophysical analysis of the interaction of rhodopsin with G protein and arrestin

scientific article published on 6 March 2015

Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide

scientific article published on 24 September 2021

Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association

scientific article published on 4 March 2016

The Activation Pathway of Human Rhodopsin in Comparison to Bovine Rhodopsin

scientific article published on 23 June 2015

The Crystal Structures of the N-terminal Photosensory Core Module of Agrobacterium Phytochrome Agp1 as Parallel and Anti-parallel Dimers

scientific article published on 26 July 2016

The Pathogenic TSH β-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR

scientific article published on 07 November 2019

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

scientific article published on 12 March 2018

The arrestin-1 finger loop interacts with two distinct conformations of active rhodopsin

scientific article published on 23 January 2018

The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways

scientific article published on 17 March 2015

The complex of tmRNA-SmpB and EF-G on translocating ribosomes

scientific article

The crystal structure of Pseudomonas aeruginosa lipoxygenase Ala420Gly mutant explains the improved oxygen affinity and the altered reaction specificity

scientific article published on 13 January 2017

The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre

scientific article

The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops

scientific article

Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity

scientific article published on 22 August 2011

Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase.

scientific article published on 20 February 2018

Ultrafast proton-coupled isomerization in the phototransformation of phytochrome

scientific article published on 16 May 2022

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

scientific article published in PLoS ONE

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