List of works - Núria Morral

A tetranucleotide repeat polymorphism in the cystic fibrosis gene

scientific article

Accurate single-day titration of adenovirus vectors based on equivalence of protein VII nuclear dots and infectious particles.

scientific article

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

scientific article published in September 2002

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

scientific article published on October 1999

Analysis of the CFTR gene confirms the high genetic heterogeneity of the Spanish population: 43 mutations account for only 78% of CF chromosomes

article

Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats

scientific article published in January 2002

Challenges for gene therapy of type 1 diabetes.

scientific article

Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies.

scientific article

Complete detection of mutations in cystic fibrosis patients of Native American origin.

scientific article

Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules

scientific article published on 4 October 2011

Cystic fibrosis in Spain: high frequency of mutation G542X in the Mediterranean coastal area

article

Cystic fibrosis in a low-incidence population: two major mutations in Finland

scientific article published on February 1994

Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

scientific article

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

article

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver

scientific article published on 21 April 2007

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice

scientific article

Gene targets of mouse miR-709: regulation of distinct pools

scientific article

Gene therapy for age-related macular degeneration.

scientific article

Gene therapy for inherited retinal and optic nerve degenerations.

scientific article published on 23 October 2017

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

scientific article

Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphicCFTR DNA markers

article

Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response

scientific article published on 19 November 2007

Identical Intragenic MicrosateUite Haplotype Found in Cystic Fibrosis Chromosomes Bearing Mutation G551D in Irish, English, Scottish, Breton and Czech Patients

article

Impact of silencing hepatic SREBP-1 on insulin signaling.

scientific article

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

scientific article

Microsatellite haplotypes for cystic fibrosis: mutation frameworks and evolutionary tracers.

scientific article

Multiplex PCR amplification of three microsatellites within the CFTR gene

scientific article published on August 1, 1992

Novel targets and therapeutic strategies for type 2 diabetes ⬇️

scientific article published on May 1, 2003

Prenatal diagnosis of cystic fibrosis by multiplex PCR of mutation and microsatellite alleles

scientific article published in August 1991

Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors.

scientific article published on January 2009

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

scientific article published on 07 January 2014

The origin of the major cystic fibrosis mutation (delta F508) in European populations.

scientific article

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

scientific article

Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): identification of a 50 kilobase deletion

article

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

scientific article published on 01 July 1999

Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors

scientific article

shRNA-induced interferon-stimulated gene analysis

scientific article published on 01 January 2012

ΔF508 GENE DELETION IN CYSTIC FIBROSIS IN SOUTHERN EUROPE

scientific article published in The Lancet

List of works by Núria Morral

A tetranucleotide repeat polymorphism in the cystic fibrosis gene

Accurate single-day titration of adenovirus vectors based on equivalence of protein VII nuclear dots and infectious particles.

Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.

Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

Analysis of the CFTR gene confirms the high genetic heterogeneity of the Spanish population: 43 mutations account for only 78% of CF chromosomes

Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats

Challenges for gene therapy of type 1 diabetes.

Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies.

Complete detection of mutations in cystic fibrosis patients of Native American origin.

Constitutive expression of short hairpin RNA in vivo triggers buildup of mature hairpin molecules

Cystic fibrosis in Spain: high frequency of mutation G542X in the Mediterranean coastal area

Cystic fibrosis in a low-incidence population: two major mutations in Finland

Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver

Enhancing hepatic mitochondrial fatty acid oxidation stimulates eating in food-deprived mice

Gene targets of mouse miR-709: regulation of distinct pools

Gene therapy for age-related macular degeneration.

Gene therapy for inherited retinal and optic nerve degenerations.

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

Haplotype analysis of 94 cystic fibrosis mutations with seven polymorphicCFTR DNA markers

Helper-dependent adenovirus-mediated short hairpin RNA expression in the liver activates the interferon response

Identical Intragenic MicrosateUite Haplotype Found in Cystic Fibrosis Chromosomes Bearing Mutation G551D in Irish, English, Scottish, Breton and Czech Patients

Impact of silencing hepatic SREBP-1 on insulin signaling.

Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

Microsatellite haplotypes for cystic fibrosis: mutation frameworks and evolutionary tracers.

Multiplex PCR amplification of three microsatellites within the CFTR gene

Novel targets and therapeutic strategies for type 2 diabetes ⬇️

Prenatal diagnosis of cystic fibrosis by multiplex PCR of mutation and microsatellite alleles

Robust hepatic gene silencing for functional studies using helper-dependent adenoviral vectors.

Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver

The origin of the major cystic fibrosis mutation (delta F508) in European populations.

Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector.

Uniparental inheritance of microsatellite alleles of the cystic fibrosis gene (CFTR): identification of a 50 kilobase deletion

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors

shRNA-induced interferon-stimulated gene analysis

ΔF508 GENE DELETION IN CYSTIC FIBROSIS IN SOUTHERN EUROPE