List of works - Vendula Sepsova

7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.

scientific article

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.

scientific article published on 10 December 2015

A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice.

scientific article published on October 2011

A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.

scientific article published on 24 October 2014

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice.

scientific article published in March 2015

A comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats ⬇️

scientific article published on April 30, 2012

A resurrection of 7-MEOTA: a comparison with tacrine.

scientific article published in October 2013

Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics

scientific article published on 2 August 2013

Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.

scientific article published on 11 December 2014

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

scientific article published on 2 October 2015

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

scientific article published on 18 January 2018

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.

scientific article published on 28 July 2017

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings.

scientific article published on 9 March 2018

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

scientific article published on 19 August 2019

Investigation of New Orexin 2 Receptor Modulators Using and In Vitro Methods

scientific article published on 09 November 2018

Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.

scientific article published on 16 November 2016

Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.

scientific article

Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine.

scientific article published on June 2014

Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study

scientific article published on 16 August 2013

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

scientific article published on 01 December 2020

Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.

scientific article published on 27 October 2015

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.

scientific article published on 26 December 2016

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.

scientific article published on 5 May 2016

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

scientific article published on 13 October 2016

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203.

scientific article published on 11 July 2017

The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice

scientific article published on 22 February 2011

The evaluation of prophylactic efficacy of newly developed reversible inhibitors of acetylcholinesterase in soman-poisoned mice - a comparison with commonly used pyridostigmine

scientific article published on 06 June 2014

The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

scientific article published in March 2014

Soubor přednášek z vojenské farmacie

book edition published in 2021

List of works by Vendula Sepsova