List of works - Fernando A Goldbaum

A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB/c mice

scientific article

A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses

scientific article

A polymeric bacterial protein activates dendritic cells via TLR4.

scientific article published in February 2006

A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants

scientific article published on 24 September 2012

A viral DNA-binding domain elicits anti-DNA antibodies of different specificities.

scientific article

Acidic pH triggers the phosphorylation of the response regulator NtrX in alphaproteobacteria.

scientific article published on 10 April 2018

Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies

scientific article

An atypical riboflavin pathway is essential for Brucella abortus virulence

scientific article

Antibody Recognition of a Flexible Epitope at the DNA Binding Site of the Human Papillomavirus Transcriptional Regulator E2†

scientific article published on 01 December 2006

Antibody response to a viral transcriptional regulator

scientific article

Blue-light-activated histidine kinases: two-component sensors in bacteria.

scientific article published on August 2007

Brucella abortus MFP: a trimeric coiled-coil protein with membrane fusogenic activity.

scientific article published on 11 July 2008

Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used

scientific article

Brucella outer membrane protein Omp31 is a haemin-binding protein

scientific article published on 19 January 2006

Brucella spp. Lumazine Synthase Induces a TLR4-Mediated Protective Response against B16 Melanoma in Mice

scientific article published on 14 May 2015

Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system.

scientific article published on 28 October 2008

Brucella spp. lumazine synthase: a novel adjuvant and antigen delivery system to effectively induce oral immunity

scientific article published on 07 February 2006

Brucella spp. lumazine synthase: a novel antigen delivery system.

scientific article

Characterization of anti-anti-idiotypic antibodies that bind antigen and an anti-idiotype ⬇️

scientific article published on August 5, 1997

Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella.

scientific article published on 3 March 2017

Crystal Structure of the Complex of the Variable Domain of Antibody D1.3 and Turkey Egg White Lysozyme: A Novel Conformational Change in Antibody CDR-L3 Selects for Antigen

article

Crystal structure of an Fv-Fv idiotope-anti-idiotope complex at 1.9 A resolution

scientific article

Crystal structures of peanut lectin in the presence of synthetic β-N- and β-S-galactosides disclose evidence for the recognition of different glycomimetic ligands

scientific article published on 13 October 2020

Crystallization and Preliminary X-Ray Diffraction Analysis of the Lumazine Synthase from Brucella abortus

scientific article published on 01 October 1998

Crystallization and preliminary X-ray characterization of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris pv. campestris

scientific article published on 14 November 2014

Crystallization and preliminary X-ray diffraction study of an idiotope-anti-idiotope Fv-Fv complex.

scientific article

Crystallographic and kinetic study of riboflavin synthase fromBrucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility

scientific article

Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function?

scientific article published in October 2005

Development of camelid single chain antibodies against Shiga toxin type 2 (Stx2) with therapeutic potential against Hemolytic Uremic Syndrome (HUS)

scientific article published on 27 April 2016

Draft Genome Sequence of Methylobacterium sp. Strain V23, Isolated from Accretion Ice of the Antarctic Subglacial Lake Vostok.

scientific article

Effective protection against experimental Taenia solium tapeworm infection in hamsters by primo-infection and by vaccination with recombinant or synthetic heterologous antigens.

scientific article published in August 2006

Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides.

scientific article published in December 2004

Evolution of vitamin B2 biosynthesis: 6,7-dimethyl-8-ribityllumazine synthases of Brucella.

scientific article published on September 2006

Expression of the Multimeric and Highly Immunogenic Brucella spp. Lumazine Synthase Fused to Bovine Rotavirus VP8d as a Scaffold for Antigen Production in Tobacco Chloroplasts.

scientific article

Extensive Identification of Bacterial Riboflavin Transporters and Their Distribution across Bacterial Species.

scientific article published on 4 May 2015

Generation of sequence-specific, high affinity anti-DNA antibodies.

scientific article published on 22 January 2001

Heterologous prime-boost oral immunization with GK-1 peptide from Taenia crassiceps cysticerci induces protective immunity

scientific article

Identification and characterization of RibN, a novel family of riboflavin transporters from Rhizobium leguminosarum and other proteobacteria.

scientific article published on 09 August 2013

Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams.

scientific article published on 11 April 2013

Immune response induced by conjunctival immunization with polymeric antigen BLSOmp31 using a thermoresponsive and mucoadhesive in situ gel as vaccine delivery system for prevention of ovine brucellosis

scientific article published on 5 July 2016

Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice

scientific article

LOV Histidine Kinase Modulates the General Stress Response System and Affects the virB Operon Expression in Brucella abortus

scientific article

Light regulates attachment, exopolysaccharide production, and nodulation in Rhizobium leguminosarum through a LOV-histidine kinase photoreceptor.

scientific article

Molecular basis of antigen mimicry by an anti-idiotope

scientific article published in Nature

Multiple display of a protein domain on a bacterial polymeric scaffold

scientific article published on 01 December 2005

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

scientific article published on 30 October 2017

New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis.

scientific article

Polymeric Display of Proteins through High Affinity Leucine Zipper Peptide Adaptors.

scientific article published on 20 March 2012

Polymeric antigen BLSOmp31 in aluminium hydroxide induces serum bactericidal and opsonic antibodies against Brucella canis in dogs.

scientific article published on 5 December 2016

Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera

scientific article

Protein motion and lock and key complementarity in antigen-antibody reactions

scientific article

Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies

scientific article

Removal of LPS from a Brucella cytoplasmic fraction by affinity chromatography with an anti-LPS monoclonal antibody as immunosorbent

scientific article published on 01 March 1994

Renewed hope for a vaccine against the intestinal adult Taenia solium.

scientific article published on August 2007

S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations.

scientific article published on 30 June 2015

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT

scientific article published on 19 January 2015

Sequence determinants of quaternary structure in lumazine synthase

scientific article published in October 2003

Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo

scientific article published on 15 June 2007

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

scientific article

Snapshots of Conformational Changes Shed Light into the NtrX Receiver Domain Signal Transduction Mechanism

scientific article

Solution and crystal structure of BA42, a protein from the Antarctic bacterium Bizionia argentinensis comprised of a stand-alone TPM domain

scientific article

Solvent Rearrangement in an Antigen—Antibody Interface Introduced by Site-directed Mutagenesis of the Antibody Combining Site

article

Specific antibody-DNA interaction: a novel strategy for tight DNA recognition

scientific article

Spray dried microspheres based on chitosan: A promising new carrier for intranasal administration of polymeric antigen BLSOmp31 for prevention of ovine brucellosis.

scientific article published on 2 February 2016

Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain

scientific article

Structural and functional characterization of a cold adapted TPM-domain with ATPase/ADPase activity

scientific article published on 31 October 2016

Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales

scientific article

Structural and physicochemical analysis of the reaction between the anti-lysozyme antibody D1.3 and the anti-idiotopic antibodies E225 and E5.2

article

Structural, functional and immunological studies on a polymeric bacterial protein

scientific article published on 01 July 2000

Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism

scientific article

Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2

scientific article

Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice.

scientific article published on 27 December 2012

The 18-kDa cytoplasmic protein of Brucella species --an antigen useful for diagnosis--is a lumazine synthase.

scientific article published in September 1999

The NtrY/X two-component system of Brucella spp. acts as a redox sensor and regulates the expression of nitrogen respiration enzymes.

scientific article published on 30 May 2012

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs

scientific article published in August 2013

The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists.

scientific article

The two-component systems PrrBA and NtrYX co-ordinately regulate the adaptation of Brucella abortus to an oxygen-limited environment.

scientific article published on 26 March 2013

The vaccine candidate BLSOmp31 protects mice against Brucella canis infection

scientific article published on 30 July 2013

The β-scaffold of the LOV domain of the Brucella light-activated histidine kinase is a key element for signal transduction

scientific article

Thermodynamics of Antigen-antibody Binding using Specific Anti-lysozyme Antibodies

scientific article published on 01 March 1995

Three-Dimensional Structure of Full-Length NtrX, an Unusual Member of the NtrC Family of Response Regulators

scientific article published on 11 January 2017

Three-dimensional structure and thermodynamics of antigen binding by anti-lysozyme antibodies

scientific article published on 01 November 1993

Three-dimensional structure of the Fab from a human IgM cold agglutinin

scientific article

X-ray crystal structure of an anti-Buckminsterfullerene antibody Fab fragment: Biomolecular recognition of C60

scientific article

Xanthomonas campestris attenuates virulence by sensing light through a bacteriophytochrome photoreceptor.

scientific article published on 12 September 2016

YqiC of Salmonella enterica serovar Typhimurium is a membrane fusogenic protein required for mice colonization ⬇️

scientific article

List of works by Fernando A Goldbaum

A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB/c mice

A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses

A polymeric bacterial protein activates dendritic cells via TLR4.

A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants

A viral DNA-binding domain elicits anti-DNA antibodies of different specificities.

Acidic pH triggers the phosphorylation of the response regulator NtrX in alphaproteobacteria.

Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies

An atypical riboflavin pathway is essential for Brucella abortus virulence

Antibody Recognition of a Flexible Epitope at the DNA Binding Site of the Human Papillomavirus Transcriptional Regulator E2†

Antibody response to a viral transcriptional regulator

Blue-light-activated histidine kinases: two-component sensors in bacteria.

Brucella abortus MFP: a trimeric coiled-coil protein with membrane fusogenic activity.

Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used

Brucella outer membrane protein Omp31 is a haemin-binding protein

Brucella spp. Lumazine Synthase Induces a TLR4-Mediated Protective Response against B16 Melanoma in Mice

Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system.

Brucella spp. lumazine synthase: a novel adjuvant and antigen delivery system to effectively induce oral immunity

Brucella spp. lumazine synthase: a novel antigen delivery system.

Characterization of anti-anti-idiotypic antibodies that bind antigen and an anti-idiotype ⬇️

Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella.

Crystal Structure of the Complex of the Variable Domain of Antibody D1.3 and Turkey Egg White Lysozyme: A Novel Conformational Change in Antibody CDR-L3 Selects for Antigen

Crystal structure of an Fv-Fv idiotope-anti-idiotope complex at 1.9 A resolution

Crystal structures of peanut lectin in the presence of synthetic β-N- and β-S-galactosides disclose evidence for the recognition of different glycomimetic ligands

Crystallization and Preliminary X-Ray Diffraction Analysis of the Lumazine Synthase from Brucella abortus

Crystallization and preliminary X-ray characterization of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris pv. campestris

Crystallization and preliminary X-ray diffraction study of an idiotope-anti-idiotope Fv-Fv complex.

Crystallographic and kinetic study of riboflavin synthase fromBrucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility

Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function?

Development of camelid single chain antibodies against Shiga toxin type 2 (Stx2) with therapeutic potential against Hemolytic Uremic Syndrome (HUS)

Draft Genome Sequence of Methylobacterium sp. Strain V23, Isolated from Accretion Ice of the Antarctic Subglacial Lake Vostok.

Effective protection against experimental Taenia solium tapeworm infection in hamsters by primo-infection and by vaccination with recombinant or synthetic heterologous antigens.

Engineering of a polymeric bacterial protein as a scaffold for the multiple display of peptides.

Evolution of vitamin B2 biosynthesis: 6,7-dimethyl-8-ribityllumazine synthases of Brucella.

Expression of the Multimeric and Highly Immunogenic Brucella spp. Lumazine Synthase Fused to Bovine Rotavirus VP8d as a Scaffold for Antigen Production in Tobacco Chloroplasts.

Extensive Identification of Bacterial Riboflavin Transporters and Their Distribution across Bacterial Species.

Generation of sequence-specific, high affinity anti-DNA antibodies.

Heterologous prime-boost oral immunization with GK-1 peptide from Taenia crassiceps cysticerci induces protective immunity

Identification and characterization of RibN, a novel family of riboflavin transporters from Rhizobium leguminosarum and other proteobacteria.

Immune response and serum bactericidal activity against Brucella ovis elicited using a short immunization schedule with the polymeric antigen BLSOmp31 in rams.

Immune response induced by conjunctival immunization with polymeric antigen BLSOmp31 using a thermoresponsive and mucoadhesive in situ gel as vaccine delivery system for prevention of ovine brucellosis

Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice

LOV Histidine Kinase Modulates the General Stress Response System and Affects the virB Operon Expression in Brucella abortus

Light regulates attachment, exopolysaccharide production, and nodulation in Rhizobium leguminosarum through a LOV-histidine kinase photoreceptor.

Molecular basis of antigen mimicry by an anti-idiotope

Multiple display of a protein domain on a bacterial polymeric scaffold

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo

New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis.

Polymeric Display of Proteins through High Affinity Leucine Zipper Peptide Adaptors.

Polymeric antigen BLSOmp31 in aluminium hydroxide induces serum bactericidal and opsonic antibodies against Brucella canis in dogs.

Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera

Protein motion and lock and key complementarity in antigen-antibody reactions

Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies

Removal of LPS from a Brucella cytoplasmic fraction by affinity chromatography with an anti-LPS monoclonal antibody as immunosorbent

Renewed hope for a vaccine against the intestinal adult Taenia solium.

S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations.

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT

Sequence determinants of quaternary structure in lumazine synthase

Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

Snapshots of Conformational Changes Shed Light into the NtrX Receiver Domain Signal Transduction Mechanism

Solution and crystal structure of BA42, a protein from the Antarctic bacterium Bizionia argentinensis comprised of a stand-alone TPM domain

Solvent Rearrangement in an Antigen—Antibody Interface Introduced by Site-directed Mutagenesis of the Antibody Combining Site

Specific antibody-DNA interaction: a novel strategy for tight DNA recognition

Spray dried microspheres based on chitosan: A promising new carrier for intranasal administration of polymeric antigen BLSOmp31 for prevention of ovine brucellosis.

Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain

Structural and functional characterization of a cold adapted TPM-domain with ATPase/ADPase activity

Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales

Structural and physicochemical analysis of the reaction between the anti-lysozyme antibody D1.3 and the anti-idiotopic antibodies E225 and E5.2

Structural, functional and immunological studies on a polymeric bacterial protein

Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism

Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2

Tandem repeats of the extracellular domain of Matrix 2 influenza protein exposed in Brucella lumazine synthase decameric carrier molecule induce protection in mice.

The 18-kDa cytoplasmic protein of Brucella species --an antigen useful for diagnosis--is a lumazine synthase.

The NtrY/X two-component system of Brucella spp. acts as a redox sensor and regulates the expression of nitrogen respiration enzymes.

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs

The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists.

The two-component systems PrrBA and NtrYX co-ordinately regulate the adaptation of Brucella abortus to an oxygen-limited environment.

The vaccine candidate BLSOmp31 protects mice against Brucella canis infection

The β-scaffold of the LOV domain of the Brucella light-activated histidine kinase is a key element for signal transduction