List of works - Claudio Brancolini

A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1.

scientific article published on 5 August 2014

Alterations in the Arf6-regulated plasma membrane endosomal recycling pathway in cells overexpressing the tetraspan protein Gas3/PMP22.

scientific article published on March 2003

Altering protein turnover in tumor cells: new opportunities for anti-cancer therapies

scientific article

Apoptotic phenotype induced by overexpression of wild-type gas3/PMP22: its relation to the demyelinating peripheral neuropathy CMT1A.

scientific article published on August 1995

Beside the MEF2 axis: unconventional functions of HDAC4.

scientific article published on 11 October 2012

CAPNS1 regulates USP1 stability and maintenance of genome integrity

scientific article

Calpain is required for macroautophagy in mammalian cells

scientific article

Caspase activation and apoptosis in response to proteasome inhibitors.

scientific article published in September 2005

Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.

scientific article published on 31 January 2002

Change in the expression of a nuclear matrix-associated protein is correlated with cellular transformation ⬇️

scientific article published on August 15, 1991

Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system

scientific article

Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis.

scientific article published on September 2011

Cut and die: proteolytic cascades regulating apoptosis.

scientific article

Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin.

scientific article

Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases.

scientific article published on September 2000

Functions of the growth arrest specific 1 gene in the development of the mouse embryo

scientific article

Gas2, a growth arrest-specific protein, is a component of the microfilament network system ⬇️

scientific article published on June 1, 1992

Gas6 anti-apoptotic signaling requires NF-kappa B activation.

scientific article

Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models ⬇️

scientific article published on 12 December 2019

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

scientific article published on 10 May 2021

HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells

scientific article published on 27 June 2019

IAPs: the last choice to survive.

scientific article published on April 2002

IFNs, ISGylation and cancer: Cui prodest?

scientific article published on 18 August 2012

Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.

scientific article

Impairment of PMP22 transgenic Schwann cells differentiation in culture: implications for Charcot-Marie-Tooth type 1A disease.

scientific article published on June 2004

Inhibitors of the ubiquitin-proteasome system are not all alike: identification of a new necrotic pathway

scientific article published on 16 May 2009

Isopeptidases in anticancer therapy: looking for inhibitors.

scientific article published on 10 May 2010

MEF2 and the tumorigenic process, hic sunt leones

scientific article published on 05 June 2018

MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation

scientific article

Measurement of caspase activity: from cell populations to individual cells.

scientific article published in January 2011

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

scientific journal article

PP2A regulates HDAC4 nuclear import

scientific article

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors.

scientific article published on 9 November 2016

Proteotoxic Stress and Cell Death in Cancer Cells

scientific article published on 23 August 2020

Regulation of class IIa HDAC activities: it is not only matter of subcellular localization

scientific article

Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22.

scientific article

Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).

scientific article

Selective class IIa HDAC inhibitors: myth or reality

scientific article published on 05 September 2014

Susceptibility to p53 dependent apoptosis correlates with increased levels of Gas2 and Gas3 proteins.

scientific article published in April 1997

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

scientific article published on 12 February 2015

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

scientific article

The DeISGylase USP18 limits TRAIL-induced apoptosis through the regulation of TRAIL levels: Cellular levels of TRAIL influences responsiveness to TRAIL-induced apoptosis.

scientific article published on 19 September 2013

The Histone Code of Senescence

scientific article published on 18 February 2020

The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB

scientific article published on 12 January 2009

The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro.

scientific article published on 24 September 2015

The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.

scientific article published on 7 February 2018

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness.

scientific article

The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase

scientific article

The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.

scientific article published in June 2001

The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells

scientific article published on 31 May 2016

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

scientific journal article

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

scientific article

Tissue transglutaminase is a caspase substrate during apoptosis. Cleavage causes loss of transamidating function and is a biochemical marker of caspase 3 activation.

scientific article

Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain

scientific article

Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription

scientific article published on 01 March 2022

Transformation by different oncogenes relies on specific metabolic adaptations.

scientific article published on 2 August 2016

Twist is substrate for caspase cleavage and proteasome-mediated degradation.

scientific article published on February 2006

Type I IFNs signaling and apoptosis resistance in glioblastoma cells.

scientific article

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

scientific article published on 15 November 2012

Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility.

scientific article

Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53-dependent senescence and favours cell transformation

scientific article published on 14 November 2018

cDNA characterization and chromosome mapping of the human GAS2 gene

scientific journal article

gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb.

scientific article published in March 1999

List of works by Claudio Brancolini

A receptor-interacting protein 1 (RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1.

Alterations in the Arf6-regulated plasma membrane endosomal recycling pathway in cells overexpressing the tetraspan protein Gas3/PMP22.

Altering protein turnover in tumor cells: new opportunities for anti-cancer therapies

Apoptotic phenotype induced by overexpression of wild-type gas3/PMP22: its relation to the demyelinating peripheral neuropathy CMT1A.

Beside the MEF2 axis: unconventional functions of HDAC4.

CAPNS1 regulates USP1 stability and maintenance of genome integrity

Calpain is required for macroautophagy in mammalian cells

Caspase activation and apoptosis in response to proteasome inhibitors.

Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.

Change in the expression of a nuclear matrix-associated protein is correlated with cellular transformation ⬇️

Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system

Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis.

Cut and die: proteolytic cascades regulating apoptosis.

Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin.

Exposure at the cell surface is required for gas3/PMP22 To regulate both cell death and cell spreading: implication for the Charcot-Marie-Tooth type 1A and Dejerine-Sottas diseases.

Functions of the growth arrest specific 1 gene in the development of the mouse embryo

Gas2, a growth arrest-specific protein, is a component of the microfilament network system ⬇️

Gas6 anti-apoptotic signaling requires NF-kappa B activation.

Genetic Programs Driving Oncogenic Transformation: Lessons from in Vitro Models ⬇️

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

HDAC7-mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells

IAPs: the last choice to survive.

IFNs, ISGylation and cancer: Cui prodest?

Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.

Impairment of PMP22 transgenic Schwann cells differentiation in culture: implications for Charcot-Marie-Tooth type 1A disease.

Inhibitors of the ubiquitin-proteasome system are not all alike: identification of a new necrotic pathway

Isopeptidases in anticancer therapy: looking for inhibitors.

MEF2 and the tumorigenic process, hic sunt leones

MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation

Measurement of caspase activity: from cell populations to individual cells.

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

PP2A regulates HDAC4 nuclear import

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors.

Proteotoxic Stress and Cell Death in Cancer Cells

Regulation of class IIa HDAC activities: it is not only matter of subcellular localization

Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22.

Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).

Selective class IIa HDAC inhibitors: myth or reality

Susceptibility to p53 dependent apoptosis correlates with increased levels of Gas2 and Gas3 proteins.

Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

The DeISGylase USP18 limits TRAIL-induced apoptosis through the regulation of TRAIL levels: Cellular levels of TRAIL influences responsiveness to TRAIL-induced apoptosis.

The Histone Code of Senescence

The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB

The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro.

The binding landscape of a partially-selective isopeptidase inhibitor with potent pro-death activity, based on the bis(arylidene)cyclohexanone scaffold.

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness.

The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase

The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.

The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

Tissue transglutaminase is a caspase substrate during apoptosis. Cleavage causes loss of transamidating function and is a biochemical marker of caspase 3 activation.

Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain

Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription

Transformation by different oncogenes relies on specific metabolic adaptations.

Twist is substrate for caspase cleavage and proteasome-mediated degradation.

Type I IFNs signaling and apoptosis resistance in glioblastoma cells.

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility.

Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53-dependent senescence and favours cell transformation

cDNA characterization and chromosome mapping of the human GAS2 gene

gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb.